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Gstp2 Gene Detail
Summary
  • Symbol
    Gstp2
  • Name
    glutathione S-transferase, pi 2
  • Synonyms
    Gst3, Gst-3, Gst p-2, GSTpiA
  • Feature Type
    protein coding gene
  • IDs
    MGI:95864
    NCBI Gene: 14869
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:4090288-4092221 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 3.75 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    54 from dbSNP Build 142
  • Strain Annotations
    14
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95864
 protein coding gene Chr19:4090285-4096023 (-)
129S1/SvImJ MGP_129S1SvImJ_G0024642
 protein coding gene Chr19:869034-870628 (-)
A/J no annotation
AKR/J MGP_AKRJ_G0024580
 protein coding gene Chr19:850632-858425 (-)
BALB/cJ MGP_BALBcJ_G0024608
 protein coding gene Chr19:829727-831232 (-)
C3H/HeJ MGP_C3HHeJ_G0024376
 protein coding gene Chr19:847647-860681 (-)
C57BL/6NJ MGP_C57BL6NJ_G0025056
 protein coding gene Chr19:881431-890452 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022484
 protein coding gene Chr19:780418-787099 (-)
CAST/EiJ MGP_CASTEiJ_G0023847
 protein coding gene Chr19:868492-871933 (-)
CBA/J MGP_CBAJ_G0024346
 protein coding gene Chr19:953715-960552 (-)
DBA/2J MGP_DBA2J_G0024474
 protein coding gene Chr19:792622-801126 (-)
FVB/NJ MGP_FVBNJ_G0024441
 protein coding gene Chr19:806429-810319 (-)
LP/J no annotation
NOD/ShiLtJ MGP_NODShiLtJ_G0024472
 protein coding gene Chr19:907242-909662 (-)
NZO/HlLtJ no annotation
PWK/PhJ MGP_PWKPhJ_G0023594
 protein coding gene Chr19:843763-845349 (-)
SPRET/EiJ no annotation
WSB/EiJ MGP_WSBEiJ_G0023910
 protein coding gene Chr19:835943-846147 (-)



Homology
more
  • Human Ortholog
    GSTP1, glutathione S-transferase pi 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GSTP1, glutathione S-transferase pi 1
  • Synonyms
    DFN7, FAEES3, GST3, GSTP, HEL-S-22, PI
  • Links
    NCBI Gene ID: 2950
    neXtProt AC: NX_P09211
    UniProt: P09211

  • Chr Location
    11q13.2; chr11:67583742-67586656 (+)  GRCh38
Human Diseases
more
  • Diseases
    54 with human GSTP1 associations

Human Disease Mouse Models
      
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Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    28 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mutant mice with null mutations in both Gstp1 and Gstp2 exhibit an increased susceptibility to DMBA and TPA induced skin papillomas. Male mutant mice exhibit an increased body weight with age.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    34
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    801
  • Tissues
    95
  • cDNA Data
    14
  • Literature Summary
    14
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 14869 NCBI Gene Model | MGI Sequence Detail 1934 C57BL/6J ±  kb
    transcript NM_181796 RefSeq | MGI Sequence Detail 785 ZRU/MplStud  
    polypeptide P46425 UniProt | EBI | MGI Sequence Detail 210 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 22
      Genomic 6
      cDNA 15
      Other 1

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGD-MRK-10306, MGD-MRK-10311, MGD-MRK-10323
    References
    more
    • Summaries
      All 71
      Developmental Gene Expression 14
      Gene Ontology 4
      Phenotypes 28
    • Earliest
      J:10161 Board PG, et al., Isolation of a cDNA clone and localization of the human glutathione S-transferase 3 genes to chromosome bands 11q13 and 12q13-14. Ann Hum Genet. 1989 Jul;53(Pt 3):205-13
    • Latest
      J:319417 van de Wetering C, et al., Glutathione-S-transferase P promotes glycolysis in asthma in association with oxidation of pyruvate kinase M2. Redox Biol. 2021 Oct 3;47:102160
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory