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Gstp2 Gene Detail
Summary
  • Symbol
    Gstp2
  • Name
    glutathione S-transferase, pi 2
  • Synonyms
    Gst3, Gst-3, Gst p-2, GSTpiA
  • Feature Type
    protein coding gene
  • IDs
    MGI:95864
    NCBI Gene: 14869
  • Gene Overview
    MyGene.info: GSTP1
Location & Maps
more
  • Genetic Map
    Chromosome 19, 3.75 cM
  • Mapping Data
    6 experiments
Homology
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  • Human Ortholog
    GSTP1, glutathione S-transferase pi 1
  • Vertebrate Orthologs
    15
  • Human Ortholog
    GSTP1, glutathione S-transferase pi 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    DFN7, FAEES3, GST3, GSTP, HEL-S-22, PI
  • Links
    NCBI Gene ID: 2950
    neXtProt AC: NX_P09211

  • Chr Location
    11q13; chr11:67583595-67586653 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 660
    1 human;3 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;2 dog;2 zebrafish;3 frog, western clawed
  • HCOP
    human homology predictions: GSTP1
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    21 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    15
  • Gene trapped
    13
  • Targeted
    2
  • Incidental Mutations
Mutant mice with null mutations in both Gstp1 and Gstp2 exhibit an increased susceptibility to DMBA and TPA induced skin papillomas. Male mutant mice exhibit an increased body weight with age.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000046063 VEGA Gene Model | MGI Sequence Detail 1952 C57BL/6J ±  kb
transcript OTTMUST00000120280 VEGA | MGI Sequence Detail 770 Not Applicable  
polypeptide OTTMUSP00000066650 VEGA | MGI Sequence Detail 210 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    54 from dbSNP Build 142
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000008393 glutathione S-transferase P 2
  • EC
  • InterPro Domains
    IPR004046 Glutathione S-transferase, C-terminal
    IPR010987 Glutathione S-transferase, C-terminal-like
    IPR004045 Glutathione S-transferase, N-terminal
    IPR003082 Glutathione S-transferase, Pi class
    IPR012336 Thioredoxin-like fold
Molecular
Reagents
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  • All nucleic 22
    Genomic 6
    cDNA 15
    Other 1

    Microarray probesets 2
Other
Accession IDs
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MGD-MRK-10306, MGD-MRK-10311, MGD-MRK-10323
References
more
  • Summaries
    All 63
    Developmental Gene Expression 13
    Gene Ontology 5
    Phenotypes 21
  • Earliest
    J:10161 Board PG, et al., Isolation of a cDNA clone and localization of the human glutathione S-transferase 3 genes to chromosome bands 11q13 and 12q13-14. Ann Hum Genet. 1989 Jul;53(Pt 3):205-13
  • Latest
    J:233693 Carvalho AN, et al., S-Glutathionylation of Keap1: a new role for glutathione S-transferase pi in neuronal protection. FEBS Lett. 2016 May;590(10):1455-66

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/23/2016
MGI 6.05
The Jackson Laboratory