Gstp2
Gene Detail

Symbol Name ID

Gstp2 glutathione S-transferase, pi 2 MGI:95864

Synonyms

Gst3, Gst-3, Gst p-2, GSTpiA

Feature Type

protein coding gene

Genetic Map

Chromosome 19

3.75 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)

Sequence Map

Chr19:4040351-4042165 bp, - strand From Ensembl annotation of GRCm38   1815 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:660  Vertebrate Homology Class
1 human; 3 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 2 dog; 2 zebrafish

Gene Tree: Gstp2

Human homologs

Human Homolog		GSTP1, glutathione S-transferase pi 1
NCBI Gene ID		2950
neXtProt AC		NX_P09211
Human Synonyms		DFN7, FAEES3, GST3, GSTP, PI
Human Chr (Location)		11q13; chr11:67351066-67354124 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(15) : Targeted(2) Gene trapped(13)
 

Mutant mice with null mutations in both Gstp1 and Gstp2 exhibit an increased susceptibility to DMBA and TPA induced skin papillomas. Male mutant mice exhibit an increased body weight with age.

 

Gene Ontology (GO) classifications

All GO classifications: (16 annotations)

Process	glutathione metabolic process, metabolic process
Component	cytoplasm, cytosol, ...
Function	dinitrosyl-iron complex binding, drug binding, ...

External Resources: FuncBase

Expression

Literature Summary: (12 records)
Data Summary: Results (95)    Tissues (95)    Images (13)
Theiler Stages: 22, 28

Assay Type	Results
Immunohistochemistry	1
RNA in situ	94

cDNA source data(5)
External Resources: GEO   ArrayExpress

Molecular reagents

All nucleic(12) Genomic(6) cDNA(5) Other(1)
Microarray probesets(2)

Other database links

Ensembl Gene Model	ENSMUSG00000038155 (Evidence)
Entrez Gene	14869 (Evidence)
DoTS	DT.102559019, DT.94162746
EC	2.5.1.18
Consensus CDS Project	CCDS29412.1
International Mouse Knockout Project Status	Gstp2

Sequences

Length	Strain/Species
genomic	ENSMUSG00000038155	Ensembl Gene Model | MGI Sequence Detail	1815	C57BL/6J
transcript	ENSMUST00000042700	Ensembl | MGI Sequence Detail	633	Not Applicable
polypeptide	ENSMUSP00000038931	Ensembl | MGI Sequence Detail	210	Not Applicable

All sequences(16) RefSeq(2) UniProt(1)

Polymorphisms

SNPs(55 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR017933	Glutathione S-transferase/chloride channel, C-terminal
InterPro	IPR004046	Glutathione S-transferase, C-terminal
InterPro	IPR010987	Glutathione S-transferase, C-terminal-like
InterPro	IPR004045	Glutathione S-transferase, N-terminal
InterPro	IPR003082	Glutathione S-transferase, Pi class
InterPro	IPR012336	Thioredoxin-like fold
Protein Ontology	PR:000008393	glutathione S-transferase P 2

References

(Earliest) J:10161 Board PG, et al., Isolation of a cDNA clone and localization of the human glutathione S-transferase 3 genes to chromosome bands 11q13 and 12q13-14. Ann Hum Genet. 1989 Jul;53(Pt 3):205-13
(Latest) J:191045 Huebner AJ, et al., Amniotic fluid activates the nrf2/keap1 pathway to repair an epidermal barrier defect in utero. Dev Cell. 2012 Dec 11;23(6):1238-46
All references(59)

Other accession IDs

MGD-MRK-10306, MGD-MRK-10311, MGD-MRK-10323