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Mstn
Gene Detail
Symbol

Name
ID
Mstn
myostatin
MGI:95691
Synonyms
Gdf8
Feature Type
protein coding gene
Genetic Map
Chromosome 1
26.99 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr1:53061640-53068079 bp, + strand
From VEGA annotation of GRCm38

  6440 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3850  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: MSTN
Protein SuperFamily: growth/differentiation factor, GDF-8/GDF-11 types
Gene Tree: Mstn

Human
homologs
MSTN, myostatin
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 2660
neXtProt AC: NX_O14793

Human Synonyms: GDF8, MSLHP

Human Chr (Location): 2q32.2; chr2:190055700-190062729 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human MSTN

Mutations,
alleles, and
phenotypes
All mutations/alleles(9) : Chemically induced (ENU)(1) Spontaneous(1) Targeted(7)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for targeted and spontaneous mutations exhibit markedly increased size of striated muscle due to both hyperplasia and hypertrophy, reduced adiposity, and increased bone mineral density.
 
Interactions
Mstn interacts with 260 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (31 annotations)
Process activation of mitophagy in response to mitochondrial depolarization, cell development, ...
Component cytoplasm, extracellular region, ...
Function cytokine activity, growth factor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (15 records)
Data Summary: Results (34)    Tissues (6)    Images (25)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 20
Western blot 4
RT-PCR 10
cDNA source data(12)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA MSTN ZFIN mstnb    NEW 
Molecular
reagents
All nucleic(19) Genomic(1) cDNA(12) Primer pair(5) Other(1)
Microarray probesets(2)
Other database
links
VEGA Gene Model OTTMUSG00000046890 (Evidence)
Ensembl Gene Model ENSMUSG00000026100 (Evidence)
Entrez Gene 17700 (Evidence)
UniGene 3514
DFCI TC1584640
DoTS DT.55114892
NIA Mouse Gene Index U000271
PDB 3SEK, 3HH2
Consensus CDS Project CCDS14950.1
International Mouse Phenotyping Consortium Status Mstn
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000046890 VEGA Gene Model | MGI Sequence Detail 6440 C57BL/6J ±  kb
transcript OTTMUST00000121584 VEGA | MGI Sequence Detail 2705 Not Applicable 
polypeptide OTTMUSP00000066957 VEGA | MGI Sequence Detail 376 Not Applicable 

For the selected sequences
All sequences(28) RefSeq(2) UniProt(5)
Polymorphisms
PCR(1) : SNPs within 2kb(48 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR015616 Growth/differentiation factor 8
InterPro IPR017948 Transforming growth factor beta, conserved site
InterPro IPR001839 Transforming growth factor-beta, C-terminal
InterPro IPR001111 Transforming growth factor-beta, N-terminal
InterPro IPR015615 Transforming growth factor-beta-related
Protein Ontology PR:000010684 growth/differentiation factor 8
References
(Earliest) J:40054 McPherron AC, et al., Regulation of skeletal muscle mass in mice by a new TGF-beta superfamily member. Nature. 1997 May 1;387(6628):83-90
(Latest) J:221341 Lun MP, et al., Spatially heterogeneous choroid plexus transcriptomes encode positional identity and contribute to regional CSF production. J Neurosci. 2015 Mar 25;35(12):4903-16
All references(147)
Other
accession IDs
MGD-MRK-10044, MGI:1196341

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory