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Mstn Gene Detail
Summary
  • Symbol
    Mstn
  • Name
    myostatin
  • Synonyms
    Gdf8
  • Feature Type
    protein coding gene
  • IDs
    MGI:95691
    NCBI Gene: 17700
  • Gene Overview
    MyGene.info: MSTN
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:53061640-53068079 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 26.99 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    48 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95691
protein coding gene Chr1:53061640-53068079 (.)
129S1/SvImJ MGP_129S1SvImJ_G0016014
protein coding gene Chr1:52589065-52596751 (+)
A/J MGP_AJ_G0015996
protein coding gene Chr1:50819413-50825852 (+)
AKR/J MGP_AKRJ_G0015952
protein coding gene Chr1:51915093-51921530 (+)
BALB/cJ MGP_BALBcJ_G0015953
protein coding gene Chr1:50646109-50652546 (+)
C3H/HeJ MGP_C3HHeJ_G0015785
protein coding gene Chr1:52293931-52300370 (+)
C57BL/6NJ MGP_C57BL6NJ_G0016404
protein coding gene Chr1:54789853-54796292 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014120
protein coding gene Chr1:41065011-41071435 (-)
CAST/EiJ MGP_CASTEiJ_G0015366
protein coding gene Chr1:51796567-51804643 (+)
CBA/J MGP_CBAJ_G0015756
protein coding gene Chr1:56255250-56261768 (+)
DBA/2J MGP_DBA2J_G0015857
protein coding gene Chr1:50092160-50098493 (+)
FVB/NJ MGP_FVBNJ_G0015859
protein coding gene Chr1:49554898-49561342 (+)
LP/J MGP_LPJ_G0015928
protein coding gene Chr1:53024964-53032037 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0015879
protein coding gene Chr1:59312249-59320953 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0016452
protein coding gene Chr1:52026187-52032631 (+)
PWK/PhJ MGP_PWKPhJ_G0015152
protein coding gene Chr1:49929730-49936174 (+)
SPRET/EiJ MGP_SPRETEiJ_G0014932
protein coding gene Chr1:51684154-51690562 (+)
WSB/EiJ MGP_WSBEiJ_G0015429
protein coding gene Chr1:51848404-51856200 (+)



Homology
more
  • Human Ortholog
    MSTN, myostatin
  • Vertebrate Orthologs
    10
  • Human Ortholog
    MSTN, myostatin
    Orthology source: HGNC, HomoloGene
  • Synonyms
    GDF8, MSLHP
  • Links
    NCBI Gene ID: 2660
    neXtProt AC: NX_O14793
    UniProt: O14793

  • Chr Location
    2q32.2; chr2:190055700-190062729 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Mstn mouse models; 1 with human MSTN associations

Human Disease Mouse Models
      
IDs
View 2 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    63 phenotypes from 11 alleles in 15 genetic backgrounds
    25 phenotypes from multigenic genotypes
    1 images
    113 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for targeted and spontaneous mutations exhibit markedly increased size of striated muscle due to both hyperplasia and hypertrophy, reduced adiposity, and increased bone mineral density.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 17700 NCBI Gene Model | MGI Sequence Detail 6440 C57BL/6J ±  kb
    transcript NM_010834 RefSeq | MGI Sequence Detail 2705 C57BL/6  
    polypeptide O08689 UniProt | EBI | MGI Sequence Detail 376 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 21
      Genomic 1
      cDNA 14
      Primer pair 5
      Other 1

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGD-MRK-10044, MGI:1196341
    References
    more
    • Summaries
      All 203
      Developmental Gene Expression 20
      Diseases 2
      Gene Ontology 20
      Phenotypes 113
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:257780 Walker RG, et al., Molecular characterization of latent GDF8 reveals mechanisms of activation. Proc Natl Acad Sci U S A. 2018 Jan 30;115(5):E866-E875

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    12/04/2018
    MGI 6.13
    The Jackson Laboratory