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Mstn
Gene Detail
 Symbol
Name
ID
Mstn
myostatin
MGI:95691
Synonyms Gdf8
Feature Type protein coding gene
Genetic Map
Chromosome 1
26.99 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr1:53061663-53068079 bp, + strand
From NCBI annotation of GRCm38

  6417 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3850  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: growth/differentiation factor, GDF-8/GDF-11 types
Gene Tree: Mstn

Human
homologs
Human Homolog MSTN, myostatin
NCBI Gene ID 2660
neXtProt AC  NX_O14793
Human Synonyms  GDF8, MSLHP
Human Chr (Location)  2q32.2; chr2:190055700-190062729 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human MSTN
Alleles
and
phenotypes
All alleles(9) : Chemically induced (ENU)(1) Spontaneous(1) Targeted(7)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for targeted and spontaneous mutations exhibit markedly increased size of striated muscle due to both hyperplasia and hypertrophy, reduced adiposity, and increased bone mineral density.
 
Gene Ontology
(GO)
classifications
All GO classifications: (19 annotations)
Process cellular response to dexamethasone stimulus, growth, ...
Component cytoplasm, extracellular region, ...
Function cytokine activity, growth factor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (13 records)
Data Summary: Results (34)    Tissues (6)    Images (25)
Theiler Stages: 18, 19, 22, 23, 25, 28
Assay TypeResults
RNA in situ 20
Western blot 4
RT-PCR 10
cDNA source data(12)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(19) Genomic(1) cDNA(12) Primer pair(5) Other(1)
Microarray probesets(2)
Other database
links
Ensembl Gene ModelENSMUSG00000026100 (Evidence)
Entrez Gene17700 (Evidence)
UniGene3514
DFCITC1584640
DoTSDT.55114892
NIA Mouse Gene IndexU000271
PDB3SEK, 3HH2
Consensus CDS ProjectCCDS14950.1
International Mouse Knockout Project StatusMstn
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 17700 NCBI Gene Model | MGI Sequence Detail 6417 C57BL/6J ±  kb
transcript NM_010834 RefSeq | MGI Sequence Detail 2682 C57BL/6 
polypeptide O08689 UniProt | EBI | MGI Sequence Detail 376 Not Applicable 

For the selected sequences
All sequences(20) RefSeq(2) UniProt(4)
Polymorphisms PCR(1) : SNPs within 2kb(47 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR015616 Growth/differentiation factor 8
InterPro IPR017948 Transforming growth factor beta, conserved site
InterPro IPR001839 Transforming growth factor-beta, C-terminal
InterPro IPR001111 Transforming growth factor-beta, N-terminal
InterPro IPR015615 Transforming growth factor-beta-related
Protein Ontology PR:000010684 growth/differentiation factor 8
Graphical View of Protein Domain Structure
References (Earliest) J:40054 McPherron AC, et al., Regulation of skeletal muscle mass in mice by a new TGF-beta superfamily member. Nature. 1997 May 1;387(6628):83-90
(Latest) J:210483 Jackson MF, et al., Myostatin regulates tissue potency and cardiac calcium-handling proteins. Endocrinology. 2014 May;155(5):1771-85
All references(133)
Other
accession IDs
MGD-MRK-10044, MGI:1196341

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory