Mstn
Gene Detail

Symbol Name ID

Mstn myostatin MGI:95691

Synonyms

Gdf8

Feature Type

protein coding gene

Genetic Map

Chromosome 1

26.99 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr1:53061663-53068079 bp, + strand From NCBI annotation of GRCm38   6417 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:3850  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: growth/differentiation factor, GDF-8/GDF-11 types
Gene Tree: Mstn

Human homologs

Human Homolog		MSTN, myostatin
NCBI Gene ID		2660
neXtProt AC		NX_O14793
Human Synonyms		GDF8, MSLHP
Human Chr (Location)		2q32.2; chr2:190920426-190927455 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human MSTN

Alleles and phenotypes

All alleles(8) : Targeted(6) Spontaneous(1) Chemically induced(1)
 

Homozygotes for targeted and spontaneous mutations exhibit markedly increased size of striated muscle due to both hyperplasia and hypertrophy, reduced adiposity, and increased bone mineral density.

 

Gene Ontology (GO) classifications

All GO classifications: (17 annotations)

Process	growth, negative regulation of muscle hypertrophy, ...
Component	cytoplasm, extracellular region, ...
Function	cytokine activity, growth factor activity, ...

External Resources: FuncBase

Expression

Literature Summary: (12 records)
Data Summary: Results (26)    Tissues (5)    Images (23)
Theiler Stages: 18, 19, 22, 23, 25

Assay Type	Results
RNA in situ	20
RT-PCR	6

cDNA source data(12)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(18) Genomic(1) cDNA(12) Primer pair(4) Other(1)
Microarray probesets(2)

Other database links

Ensembl Gene Model	ENSMUSG00000026100 (Evidence)
Entrez Gene	17700 (Evidence)
UniGene	3514
DFCI	TC1584640
DoTS	DT.55114892
NIA Mouse Gene Index	U000271
PDB	3SEK, 3HH2
Consensus CDS Project	CCDS14950.1
International Mouse Knockout Project Status	Mstn

Sequences

Length	Strain/Species
genomic	17700	NCBI Gene Model | MGI Sequence Detail	6417	C57BL/6J
transcript	NM_010834	RefSeq | MGI Sequence Detail	2682	C57BL/6
polypeptide	O08689	UniProt | EBI | MGI Sequence Detail	376	Not Applicable

All sequences(20) RefSeq(2) UniProt(4)

Polymorphisms

PCR(1) : SNPs(37 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR015616	Growth/differentiation factor 8
InterPro	IPR017948	Transforming growth factor beta, conserved site
InterPro	IPR001839	Transforming growth factor-beta, C-terminal
InterPro	IPR001111	Transforming growth factor-beta, N-terminal
InterPro	IPR015615	Transforming growth factor-beta-related
Protein Ontology	PR:000010684	growth/differentiation factor 8

Graphical View of Protein Domain Structure

References

(Earliest) J:40054 McPherron AC, et al., Regulation of skeletal muscle mass in mice by a new TGF-beta superfamily member. Nature. 1997 May 1;387(6628):83-90
(Latest) J:191816 Karst S, et al., Genomic imprinting and genetic effects on muscle traits in mice. BMC Genomics. 2012;13:408
All references(123)

Other accession IDs

MGD-MRK-10044, MGI:1196341