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Mstn Gene Detail
Summary
  • Symbol
    Mstn
  • Name
    myostatin
  • Synonyms
    Gdf8
  • Feature Type
    protein coding gene
  • IDs
    MGI:95691
    NCBI Gene: 17700
  • Alliance
    genome feature page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:53100799-53107238 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 26.99 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    144 from dbSNP Build 142
  • Strain Annotations
    19
  • PCR
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95691
 protein coding gene Chr1:53100799-53107238 (+)
129S1/SvImJ ENSMUSG00200001808
 protein coding gene Chr1:50575691-50582130 (+)
A/J ENSMUSG00195029270
 protein coding gene Chr1:50475321-50481760 (+)
AKR/J ENSMUSG00220003209
 protein coding gene Chr1:50231374-50237811 (+)
BALB/cJ ENSMUSG00180003091
 protein coding gene Chr1:50407021-50413458 (+)
C3H/HeJ ENSMUSG00175001049
 protein coding gene Chr1:50501517-50507956 (+)
C57BL/6NJ ENSMUSG00215002918
 protein coding gene Chr1:50428932-50435371 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014120
 protein coding gene Chr1:41065011-41071435 (-)
CAST/EiJ ENSTCUG00005000776
 protein coding gene Chr1:50317749-50324195 (+)
CBA/J ENSMUSG00210028642
 protein coding gene Chr1:50206846-50213285 (+)
DBA/2J ENSMUSG00185037423
 protein coding gene Chr1:51326466-51332905 (+)
FVB/NJ ENSMUSG00205003309
 protein coding gene Chr1:50166837-50173276 (+)
JF1/MsJ ENSUMUG00000000983
 protein coding gene Chr1:50282368-50288820 (+)
LP/J ENSMUSG00230027758
 protein coding gene Chr1:51322693-51329132 (+)
NOD/ShiLtJ ENSMUSG00190002582
 protein coding gene Chr1:50343574-50350011 (+)
NZO/HlLtJ ENSMUSG00225008781
 protein coding gene Chr1:54508429-54514873 (+)
PWK/PhJ ENSLUMG00010002272
 protein coding gene Chr1:49840109-49846553 (+)
SPRET/EiJ ENSMSPG00010025672
 protein coding gene Chr1:51561631-51568039 (+)
WSB/EiJ ENSIUOG00005003431
 protein coding gene Chr1:50037425-50043864 (+)



Homology
more
  • Human Ortholog
    MSTN, myostatin
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MSTN, myostatin
  • Synonyms
    GDF8, MSLHP
  • Links
    NCBI Gene ID: 2660
    UniProt: O14793

  • Chr Location
    2q32.2; chr2:190055700-190062729 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Mstn mouse models; 1 with human MSTN associations

Human Disease Mouse Models
      
IDs
 View 2 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    81 phenotypes from 12 alleles in 17 genetic backgrounds
    21 phenotypes from multigenic genotypes
    1 images
    149 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for targeted and spontaneous mutations exhibit markedly increased size of striated muscle due to both hyperplasia and hypertrophy, reduced adiposity, and increased bone mineral density.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    73
  • GO References
    24
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    690
  • Tissues
    54
  • cDNA Data
    16
  • Literature Summary
    27
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 17700 NCBI Gene Model | MGI Sequence Detail 6440 C57BL/6J ±  kb
    transcript NM_010834 RefSeq | MGI Sequence Detail 2705 ZRU/MplStud  
    polypeptide O08689 UniProt | EBI | MGI Sequence Detail 376 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 29
      Genomic 1
      cDNA 16
      Primer pair 9
      Other 3
      Antibodies 1

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGD-MRK-10044, MGI:1196341
    References
    more
    • Summaries
      All 301
      Developmental Gene Expression 27
      Diseases 2
      Gene Ontology 24
      Phenotypes 149
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:362883 Ongaro L, et al., Muscle-derived myostatin is a major endocrine driver of follicle-stimulating hormone synthesis. Science. 2025 Jan 17;387(6731):329-336
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory