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Mstntm1Sjl
Targeted Allele Detail
Summary
Symbol: Mstntm1Sjl
Name: myostatin; targeted mutation 1, Se-Jin Lee
MGI ID: MGI:2148177
Synonyms: mstn-, MSTN-KO
Gene: Mstn  Location: Chr1:53100799-53107238 bp, + strand  Genetic Position: Chr1, 26.99 cM
Alliance: Mstntm1Sjl page
Skeletal defects in Gdf11tm1Sjl/Gdf11tm1Sjl and Mstntm1Sjl/Mstntm1Sjl Gdf11tm1Sjl/Gdf11tm1Sjl newborn mice

Show the 1 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:40054
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsReplacement of the sequences encoding the entire C-terminal region of the protein with a neomycin cassette. (J:40054)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Mice Carrying this Mutation: 2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation: 11 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Mstn Mutation:  33 strains or lines available
References
Original:  J:40054 McPherron AC, et al., Regulation of skeletal muscle mass in mice by a new TGF-beta superfamily member. Nature. 1997 May 1;387(6628):83-90
All:  89 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
06/12/2024
MGI 6.13
The Jackson Laboratory