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Phenotypes Associated with This Genotype
Genotype
MGI:3714749
Allelic
Composition
Mstntm1Sjl/Mstntm1Sjl
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mstntm1Sjl mutation (2 available); any Mstn mutation (33 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• abnormal body shape, with pronounced shoulders and hips
• 30% larger
• significantly higher body weights at 4, 5, and 6 weeks of age

muscle
• mean fiber diameter of the tibilais cranialis muscle and gastrocnemius muscle is 7% and 22% larger, respectively, than in wild-type, indicating muscle cell hypertrophy
• at the widest portion of the tibialis cranialis muscle, the total cell number is 86% higher than in wild-type, indicating muscle cell hyperplasia
• individual muscles weight 2-3 times more than of wild-type
• large and widespread increase in skeletal muscle mass
• gluteus muscle is larger at 8 and 12 weeks of age

adipose tissue
• at 12 weeks of age, show decreased fat depots
• weight is lighter at 8 and 12 weeks of age
• weight is lighter at 4, 8, and 12 weeks of age
• weight is lighter at 12 weeks of age
• parametrial fat pads are lighter at 8 weeks of age

behavior/neurological
• food intake is higher, but only at 4 and 7 weeks of age

homeostasis/metabolism
• serum leptin concentration is lower at 4 and 12 weeks of age but not at 8 weeks of age
• at 12 weeks of age, lipid content is lower

liver/biliary system
• liver weights as a proportion of total body weight of mutants are less than those of wild-type at 4, 8, and 12 weeks of age

renal/urinary system
• kidney weights as a proportion of total body weight of mutants are less than those of wild-type at 4 and 8 weeks of age

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
myostatin-related muscle hypertrophy DOID:0111072 OMIM:614160
J:40054


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
06/12/2024
MGI 6.13
The Jackson Laboratory