About   Help   FAQ
Ebf1 Gene Detail
Summary
  • Symbol
    Ebf1
  • Name
    early B cell factor 1
  • Synonyms
    O/E-1, Olf1, Olf-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:95275
    NCBI Gene: 13591
  • Gene Overview
    MyGene.info: EBF1
  • Alliance
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:44618100-45008096 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 26.45 cM
  • Mapping Data
    7 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2557 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95275
protein coding gene Chr11:44617317-45008096 (+)
129S1/SvImJ MGP_129S1SvImJ_G0018183
protein coding gene Chr11:43468714-43881089 (+)
A/J MGP_AJ_G0018155
protein coding gene Chr11:41797188-42196996 (+)
AKR/J MGP_AKRJ_G0018119
protein coding gene Chr11:43030305-43436004 (+)
BALB/cJ MGP_BALBcJ_G0018124
protein coding gene Chr11:41983390-42377885 (+)
C3H/HeJ MGP_C3HHeJ_G0017937
protein coding gene Chr11:43058308-43462337 (+)
C57BL/6NJ MGP_C57BL6NJ_G0018578
protein coding gene Chr11:44759186-45176808 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0016233
protein coding gene Chr11:39832314-40223967 (+)
CAST/EiJ MGP_CASTEiJ_G0017501
protein coding gene Chr11:43144712-43570407 (+)
CBA/J MGP_CBAJ_G0017910
protein coding gene Chr11:46872603-47302563 (+)
DBA/2J MGP_DBA2J_G0018020
protein coding gene Chr11:41557469-41948645 (+)
FVB/NJ MGP_FVBNJ_G0018014
protein coding gene Chr11:41237751-41632441 (+)
LP/J MGP_LPJ_G0018092
protein coding gene Chr11:43713314-44119566 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0018038
protein coding gene Chr11:48475657-48892849 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0018617
protein coding gene Chr11:43185458-43591578 (+)
PWK/PhJ MGP_PWKPhJ_G0017281
protein coding gene Chr11:41617685-42020125 (+)
SPRET/EiJ MGP_SPRETEiJ_G0017074
protein coding gene Chr11:42984666-43394896 (+)
WSB/EiJ MGP_WSBEiJ_G0017550
protein coding gene Chr11:42820906-43236611 (+)



Homology
more
  • Human Ortholog
    EBF1, EBF transcription factor 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    EBF1, EBF transcription factor 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    COE1, EBF, O/E-1, OLF1
  • Links
    NCBI Gene ID: 1879
    neXtProt AC: NX_Q9UH73
    UniProt: Q9UH73

  • Chr Location
    5q33.3; chr5:158695915-159099762 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Ebf1 mouse models

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    59 phenotypes from 9 alleles in 13 genetic backgrounds
    2 phenotypes from multigenic genotypes
    50 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for a targeted null mutation exhibit a reduced striatum due to excess apoptosis, altered facial branchiomotor neurone migration, and a block in B cell differentiation. Mutants are smaller than normal and many die prior to 4 weeks of age.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 13591 NCBI Gene Model | MGI Sequence Detail 389997 C57BL/6J ±  kb
    transcript NM_001362575 RefSeq | MGI Sequence Detail 5334 C57BL/6  
    polypeptide Q07802 UniProt | EBI | MGI Sequence Detail 591 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 44
      cDNA 28
      Primer pair 6
      Other 10

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGD-MRK-9290, MGI:2144593
    References
    more
    • Summaries
      All 212
      Developmental Gene Expression 123
      Diseases 1
      Gene Ontology 8
      Phenotypes 50
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:272505 Catela C, et al., An ancient role for collier/Olf/Ebf (COE)-type transcription factors in axial motor neuron development. Neural Dev. 2019 Jan 18;14(1):2

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer & Copyright Notice
    Send questions and comments to User Support.
    last database update
    10/08/2019
    MGI 6.14
    The Jackson Laboratory