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Ebf1
Gene Detail
Symbol

Name
ID
Ebf1
early B cell factor 1
MGI:95275
Synonyms
O/E-1, Olf1, Olf-1
Feature Type
protein coding gene
Genetic Map
Chromosome 11
26.45 cM
Detailed Genetic Map ± 1 cM


Mapping data(7)
Sequence Map
Chr11:44617317-45008091 bp, + strand
From VEGA annotation of GRCm38

  390775 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7297  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: EBF1
Protein SuperFamily: transcription factor, collier type
Gene Tree: Ebf1

Human
homologs
EBF1, early B-cell factor 1
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 1879
neXtProt AC: NX_Q9UH73

Human Synonyms: COE1, EBF, O/E-1, OLF1

Human Chr (Location): 5q34; chr5:158695908-159099780 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(27) : Gene trapped(21) Spontaneous(1) Targeted(5)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygotes for a targeted null mutation exhibit a reduced striatum due to excess apoptosis, altered facial branchiomotor neurone migration, and a block in B cell differentiation. Mutants are smaller than normal and many die prior to 4 weeks of age.
 
Interactions
Ebf1 interacts with 430 markers (Mir1b, Mir7-1, Mir9-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (15 annotations)
Process multicellular organismal development, positive regulation of transcription, DNA-templated, ...
Component nucleus
Function C2H2 zinc finger domain binding, DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (97 records)
Data Summary: Results (392)    Tissues (243)    Images (104)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 100
RNA in situ 278
RT-PCR 14
cDNA source data(24)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA EBF1    NEW 
Molecular
reagents
All nucleic(40) cDNA(27) Primer pair(6) Other(7)
Microarray probesets(8)
Other database
links
VEGA Gene Model OTTMUSG00000005474 (Evidence)
Ensembl Gene Model ENSMUSG00000057098 (Evidence)
Entrez Gene 13591 (Evidence)
DFCI TC1576969, TC1583937, TC1607236, TC1620167
DoTS DT.101708900, DT.525987, DT.91445319
NIA Mouse Gene Index U012493, U181605
PDB 3MLN, 3MLO, 3MLP
Consensus CDS Project CCDS24566.1, CCDS70165.1
International Mouse Phenotyping Consortium Status Ebf1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005474 VEGA Gene Model | MGI Sequence Detail 390775 C57BL/6J ±  kb
transcript OTTMUST00000012188 VEGA | MGI Sequence Detail 3422 Not Applicable 
polypeptide OTTMUSP00000005624 VEGA | MGI Sequence Detail 592 Not Applicable 

For the selected sequences
All sequences(71) RefSeq(16) UniProt(8)
Polymorphisms
RFLP(2) : SNPs within 2kb(2570 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002909 Cell surface receptor IPT/TIG
InterPro IPR014756 Immunoglobulin E-set
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
InterPro IPR003523 Transcription factor COE
InterPro IPR018350 Transcription factor COE, conserved site
Protein Ontology PR:000001942 transcription factor COE1
References
(Earliest) J:4971 Hagman J, et al., Cloning and functional characterization of early B-cell factor, a regulator of lymphocyte-specific gene expression. Genes Dev. 1993 May;7(5):760-73
(Latest) J:220860 Magnani D, et al., The ciliogenic transcription factor Rfx3 is required for the formation of the thalamocortical tract by regulating the patterning of prethalamus and ventral telencephalon. Hum Mol Genet. 2015 May 1;24(9):2578-93
All references(165)
Other
accession IDs
MGD-MRK-9290, MGI:2144593

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory