About   Help   FAQ
Ebf1 Gene Detail
Summary
  • Symbol
    Ebf1
  • Name
    early B cell factor 1
  • Synonyms
    O/E-1, Olf1, Olf-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:95275
    NCBI Gene: 13591
  • Alliance
  • Transcription Start Sites
    38 TSS
  • Candidate for QTL
    1 QTL
Location &
Maps
more
  • Sequence Map
    Chr11:44508144-44898918 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 11, 26.45 cM
  • Mapping Data
    7 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2558 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95275
protein coding gene Chr11:44502738-44898923 (+)
129S1/SvImJ MGP_129S1SvImJ_G0018183
protein coding gene Chr11:43468714-43881089 (+)
A/J MGP_AJ_G0018155
protein coding gene Chr11:41797188-42196996 (+)
AKR/J MGP_AKRJ_G0018119
protein coding gene Chr11:43030305-43436004 (+)
BALB/cJ MGP_BALBcJ_G0018124
protein coding gene Chr11:41983390-42377885 (+)
C3H/HeJ MGP_C3HHeJ_G0017937
protein coding gene Chr11:43058308-43462337 (+)
C57BL/6NJ MGP_C57BL6NJ_G0018578
protein coding gene Chr11:44759186-45176808 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0016233
protein coding gene Chr11:39832314-40223967 (+)
CAST/EiJ MGP_CASTEiJ_G0017501
protein coding gene Chr11:43144712-43570407 (+)
CBA/J MGP_CBAJ_G0017910
protein coding gene Chr11:46872603-47302563 (+)
DBA/2J MGP_DBA2J_G0018020
protein coding gene Chr11:41557469-41948645 (+)
FVB/NJ MGP_FVBNJ_G0018014
protein coding gene Chr11:41237751-41632441 (+)
LP/J MGP_LPJ_G0018092
protein coding gene Chr11:43713314-44119566 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0018038
protein coding gene Chr11:48475657-48892849 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0018617
protein coding gene Chr11:43185458-43591578 (+)
PWK/PhJ MGP_PWKPhJ_G0017281
protein coding gene Chr11:41617685-42020125 (+)
SPRET/EiJ MGP_SPRETEiJ_G0017074
protein coding gene Chr11:42984666-43394896 (+)
WSB/EiJ MGP_WSBEiJ_G0017550
protein coding gene Chr11:42820906-43236611 (+)



Homology
more
  • Human Ortholog
    EBF1, EBF transcription factor 1
  • Vertebrate Orthologs
    5
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    EBF1, EBF transcription factor 1
  • Synonyms
    COE1, EBF, O/E-1, OLF1
  • Links
    NCBI Gene ID: 1879
    neXtProt AC: NX_Q9UH73
    UniProt: Q9UH73

  • Chr Location
    5q33.3; chr5:158695920-159099916 (-)  GRCh38

Human Diseases
more
  • Diseases
    1 with Ebf1 mouse models

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    75 phenotypes from 9 alleles in 13 genetic backgrounds
    3 phenotypes from multigenic genotypes
    65 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a targeted null mutation exhibit a reduced striatum due to excess apoptosis, altered facial branchiomotor neurone migration, and a block in B cell differentiation. Mutants are smaller than normal and many die prior to 4 weeks of age.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000057098 Ensembl Gene Model | MGI Sequence Detail 390775 C57BL/6J ±  kb
    transcript ENSMUST00000101326 Ensembl | MGI Sequence Detail 3422 Not Applicable  
    polypeptide ENSMUSP00000099857 Ensembl | MGI Sequence Detail 592 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 54
      cDNA 31
      Primer pair 11
      Other 12

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGD-MRK-9290, MGI:2144593
    References
    more
    • Summaries
      All 260
      Developmental Gene Expression 152
      Diseases 1
      Gene Ontology 7
      Phenotypes 65
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:345358 Wang X, et al., SoxC transcription factors shape the epigenetic landscape to establish competence for sensory differentiation in the mammalian organ of Corti. Proc Natl Acad Sci U S A. 2023 Aug 22;120(34):e2301301120

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.
    last database update
    03/12/2024
    MGI 6.23
    The Jackson Laboratory