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Ebf1
Gene Detail
 Symbol
Name
ID
Ebf1
early B cell factor 1
MGI:95275
BioType Conflict
Synonyms O/E-1, Olf1, Olf-1
Feature Type protein coding gene
Genetic Map
Chromosome 11
26.45 cM
Detailed Genetic Map ± 1 cM


Mapping data(7)
Sequence Map
Chr11:44617317-45008091 bp, + strand
From VEGA annotation of GRCm38

  390775 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7297  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: transcription factor, collier type

Human
homologs
Human Homolog EBF1, early B-cell factor 1
NCBI Gene ID 1879
neXtProt AC  NX_Q9UH73
Human Synonyms  COE1, EBF, O/E-1, OLF1
Human Chr (Location)  5q34; chr5:158695908-159099780 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(24) : Gene trapped(21) Spontaneous(1) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for a targeted null mutation exhibit a reduced striatum due to excess apoptosis, altered facial branchiomotor neurone migration, and a block in B cell differentiation. Mutants are smaller than normal and many die prior to 4 weeks of age.
 
Interactions
Ebf1 interacts with 431 markers (Mir1b, Mir7-1, Mir9-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (11 annotations)
Process multicellular organismal development, positive regulation of transcription, DNA-templated, ...
Component nucleus
Function C2H2 zinc finger domain binding, DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (92 records)
Data Summary: Results (392)    Tissues (243)    Images (104)
Theiler Stages: 2, 3, 4, 5, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28
Assay TypeResults
Immunohistochemistry 100
RNA in situ 278
RT-PCR 14
cDNA source data(24)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(40) cDNA(27) Primer pair(6) Other(7)
Microarray probesets(8)
Other database
links
VEGA Gene ModelOTTMUSG00000005474 (Evidence)
Ensembl Gene ModelENSMUSG00000057098 (Evidence), ENSMUSG00000078561 (Evidence)
Entrez Gene13591 (Evidence)
DFCITC1576969, TC1583937, TC1607236, TC1620167
DoTSDT.101708900, DT.525987, DT.91445319
NIA Mouse Gene IndexU012493, U181605
PDB3MLN, 3MLO, 3MLP
Consensus CDS ProjectCCDS24566.1, CCDS70165.1
International Mouse Knockout Project StatusEbf1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005474 VEGA Gene Model | MGI Sequence Detail 390775 C57BL/6J ±  kb
transcript OTTMUST00000012188 VEGA | MGI Sequence Detail 3422 Not Applicable 
polypeptide OTTMUSP00000005624 VEGA | MGI Sequence Detail 592 Not Applicable 

For the selected sequences
All sequences(73) RefSeq(16) UniProt(8)
Polymorphisms RFLP(2) : SNPs within 2kb(2570 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002909 Cell surface receptor IPT/TIG
InterPro IPR014756 Immunoglobulin E-set
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
InterPro IPR003523 Transcription factor COE
InterPro IPR018350 Transcription factor COE, conserved site
Protein Ontology PR:000001942 transcription factor COE1
References (Earliest) J:4971 Hagman J, et al., Cloning and functional characterization of early B-cell factor, a regulator of lymphocyte-specific gene expression. Genes Dev. 1993 May;7(5):760-73
(Latest) J:210221 Mandai K, et al., Linx Mediates Interaxonal Interactions and Formation of the Internal Capsule. Neuron. 2014 Jun 11;
All references(160)
Other
accession IDs
MGD-MRK-9290, MGI:2144593

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory