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Comt Gene Detail
Summary
  • Symbol
    Comt
  • Name
    catechol-O-methyltransferase
  • Synonyms
    Comt1, D16Wsu103e, D330014B15Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:88470
    NCBI Gene: 12846
  • Gene Overview
    MyGene.info: COMT
Location & Maps
more
  • Sequence Map
    Chr16:18407346-18426852 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      19507 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 16, 11.40 cM
  • Mapping Data
    17 experiments
Homology
more
  • Human Ortholog
    COMT, catechol-O-methyltransferase
  • Vertebrate Orthologs
    11
  • Human Ortholog
    COMT, catechol-O-methyltransferase
    Orthology source: HomoloGene
  • Synonyms
    HEL-S-98n
  • Links
    NCBI Gene ID: 1312
    neXtProt AC: NX_P21964

  • Chr Location
    22q11.21; chr22:19941740-19969975 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with Comt mouse models; 3 with human COMT associations

Human Disease Mouse Models
       Preeclampsia/Eclampsia 1; PEE1   OMIM: 189800 View 1 model
       Catechol-O-Methyltransferase; COMT   OMIM: 116790
Panic Disorder 1; PAND1   OMIM: 167870
Schizophrenia; SCZD   OMIM: 181500
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    13 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    34 phenotypes from 5 alleles in 6 genetic backgrounds
    16 phenotypes from multigenic genotypes
    76 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    31
  • Gene trapped
    14
  • Spontaneous
    1
  • Targeted
    14
  • Transgenic
    2
  • Genomic Mutations
    7 involving Comt
  • Incidental Mutations
Mice homozygous for disruption of this gene are viable, fertile, and show no gross or histological abnormalities. However dopamine levels in the frontal cortex of males are increased. Also, males show increased aggression and females show increased anxiety.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000026238 VEGA Gene Model | MGI Sequence Detail 19507 C57BL/6J ±  kb
transcript OTTMUST00000064320 VEGA | MGI Sequence Detail 1786 Not Applicable  
polypeptide OTTMUSP00000031924 VEGA | MGI Sequence Detail 265 Not Applicable  
For the selected sequence
Polymorphisms
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  • RFLP
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000005731 catechol O-methyltransferase
  • PDB
  • EC
  • InterPro Domains
    IPR017128 Catechol O-methyltransferase, eukaryotic
    IPR002935 O-methyltransferase, family 3
    IPR029063 S-adenosyl-L-methionine-dependent methyltransferase
Molecular
Reagents
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  • All nucleic 40
    Genomic 19
    cDNA 16
    Primer pair 5

    Microarray probesets 6
Other
Accession IDs
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MGD-MRK-2092, MGD-MRK-33988, MGI:106296, MGI:2441969
References
more
  • Summaries
    All 88
    Developmental Gene Expression 11
    Diseases 13
    Gene Ontology 9
    Phenotypes 76
  • Earliest
    J:14038 Bucan M, et al., Comparative mapping of 9 human chromosome 22q loci in the laboratory mouse. Hum Mol Genet. 1993 Aug;2(8):1245-52
  • Latest
    J:224284 Risbrough V, et al., Generation and characterization of humanized mice carrying COMT158 Met/Val alleles. Neuropsychopharmacology. 2014 Jul;39(8):1823-32

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory