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Comt Gene Detail
Summary
  • Symbol
    Comt
  • Name
    catechol-O-methyltransferase
  • Synonyms
    Comt1, D16Wsu103e, D330014B15Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:88470
    NCBI Gene: 12846
  • Alliance
    genome feature page
  • Transcription Start Sites
    18 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:18225636-18245602 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 11.40 cM
  • Mapping Data
    17 experiments
Strain
Comparison
more
  • Strain Annotations
    19
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88470
 protein coding gene Chr16:18225632-18247006 (-)
129S1/SvImJ ENSMUSG00200046308
 protein coding gene Chr16:15222410-15242356 (-)
A/J ENSMUSG00195034479
 protein coding gene Chr16:14779742-14799705 (-)
AKR/J ENSMUSG00220045079
 protein coding gene Chr16:15096009-15115971 (-)
BALB/cJ ENSMUSG00180039335
 protein coding gene Chr16:15021016-15041002 (-)
C3H/HeJ ENSMUSG00175041851
 protein coding gene Chr16:15165979-15185720 (-)
C57BL/6NJ ENSMUSG00215039688
 protein coding gene Chr16:14887082-14907056 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020545
 protein coding gene Chr16:14892116-14911372 (-)
CAST/EiJ ENSTCUG00005040857
 protein coding gene Chr16:15092653-15112588 (-)
CBA/J ENSMUSG00210042086
 protein coding gene Chr16:15182287-15202029 (-)
DBA/2J ENSMUSG00185030738
 protein coding gene Chr16:15126906-15146643 (-)
FVB/NJ ENSMUSG00205046150
 protein coding gene Chr16:15136424-15156167 (-)
JF1/MsJ ENSUMUG00000052230
 protein coding gene Chr16:15223943-15244075 (-)
LP/J ENSMUSG00230038760
 protein coding gene Chr16:17706326-17726063 (-)
NOD/ShiLtJ ENSMUSG00190042266
 protein coding gene Chr16:15268320-15288277 (-)
NZO/HlLtJ ENSMUSG00225036623
 protein coding gene Chr16:20952134-20971875 (-)
PWK/PhJ ENSLUMG00010041954
 protein coding gene Chr16:15102112-15121992 (-)
SPRET/EiJ ENSMSPG00010037596
 protein coding gene Chr16:15105874-15125820 (-)
WSB/EiJ ENSIUOG00005041730
 protein coding gene Chr16:15262235-15281975 (-)



Homology
more
  • Human Ortholog
    COMT, catechol-O-methyltransferase
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    COMT, catechol-O-methyltransferase
  • Synonyms
    HEL-S-98n
  • Links
    NCBI Gene ID: 1312
    UniProt: P21964

  • Chr Location
    22q11.21; chr22:19941371-19969975 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with Comt mouse models; 36 with human COMT associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
 View 1 model
      
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Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    8 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    40 phenotypes from 6 alleles in 7 genetic backgrounds
    13 phenotypes from multigenic genotypes
    213 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruption of this gene are viable, fertile, and show no gross or histological abnormalities. However dopamine levels in the frontal cortex of males are increased. Also, males show increased aggression and females show increased anxiety.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    129
  • GO References
    41
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1076
  • Tissues
    202
  • cDNA Data
    15
  • Literature Summary
    17
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000000326 Ensembl Gene Model | MGI Sequence Detail 19967 C57BL/6J ±  kb
    transcript ENSMUST00000000335 Ensembl | MGI Sequence Detail 1397 Not Applicable  
    polypeptide ENSMUSP00000000335 Ensembl | MGI Sequence Detail 265 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 42
      Genomic 19
      cDNA 17
      Primer pair 5
      Other 1
      Antibodies 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-2092, MGD-MRK-33988, MGI:106296, MGI:2441969
    References
    more
    • Summaries
      All 280
      Developmental Gene Expression 17
      Diseases 8
      Gene Ontology 41
      Phenotypes 213
    • Earliest
      J:14038 Bucan M, et al., Comparative mapping of 9 human chromosome 22q loci in the laboratory mouse. Hum Mol Genet. 1993 Aug;2(8):1245-52
    • Latest
      J:390319 Son GY, et al., Dysregulated calcium signaling underlies hyposalivation and microbial dysbiosis in Down syndrome. Cell Rep. 2026 Jul 1;:117619
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory