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Comt Gene Detail
Summary
  • Symbol
    Comt
  • Name
    catechol-O-methyltransferase
  • Synonyms
    Comt1, D16Wsu103e, D330014B15Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:88470
    NCBI Gene: 12846
  • Gene Overview
    MyGene.info: COMT
  • Alliance
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:18406882-18426716 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 16, 11.40 cM
  • Mapping Data
    17 experiments
Strain
Comparison
more
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88470
protein coding gene Chr16:18406882-18426852 (-)
129S1/SvImJ MGP_129S1SvImJ_G0022610
protein coding gene Chr16:15632878-15652426 (-)
A/J MGP_AJ_G0022571
protein coding gene Chr16:14855746-14876689 (-)
AKR/J MGP_AKRJ_G0022548
protein coding gene Chr16:15447955-15468931 (-)
BALB/cJ MGP_BALBcJ_G0022576
protein coding gene Chr16:15004551-15025019 (-)
C3H/HeJ MGP_C3HHeJ_G0022343
protein coding gene Chr16:15597892-15617457 (-)
C57BL/6NJ MGP_C57BL6NJ_G0023025
protein coding gene Chr16:15906935-15934427 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020545
protein coding gene Chr16:14892116-14911372 (-)
CAST/EiJ MGP_CASTEiJ_G0021870
protein coding gene Chr16:15495388-15520848 (-)
CBA/J MGP_CBAJ_G0022312
protein coding gene Chr16:16618474-16643016 (-)
DBA/2J MGP_DBA2J_G0022444
protein coding gene Chr16:14772651-14792451 (-)
FVB/NJ MGP_FVBNJ_G0022419
protein coding gene Chr16:14828860-14848537 (-)
LP/J MGP_LPJ_G0022511
protein coding gene Chr16:15401400-15419673 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0022441
protein coding gene Chr16:16247722-16268854 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0023036
protein coding gene Chr16:15380398-15399977 (-)
PWK/PhJ MGP_PWKPhJ_G0021612
protein coding gene Chr16:15039239-15059840 (-)
SPRET/EiJ MGP_SPRETEiJ_G0021440
protein coding gene Chr16:15337358-15356473 (-)
WSB/EiJ MGP_WSBEiJ_G0021916
protein coding gene Chr16:15375259-15396025 (-)



Homology
more
  • Human Ortholog
    COMT, catechol-O-methyltransferase
  • Vertebrate Orthologs
    11
  • Human Ortholog
    COMT, catechol-O-methyltransferase
    Orthology source: HomoloGene, HGNC
  • Synonyms
    HEL-S-98n
  • Links
    NCBI Gene ID: 1312
    neXtProt AC: NX_P21964
    UniProt: P21964

  • Chr Location
    22q11.21; chr22:19941740-19969975 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Comt mouse models; 2 with human COMT associations

Human Disease Mouse Models
      
IDs
View 1 model
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    6 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    34 phenotypes from 5 alleles in 6 genetic backgrounds
    16 phenotypes from multigenic genotypes
    97 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for disruption of this gene are viable, fertile, and show no gross or histological abnormalities. However dopamine levels in the frontal cortex of males are increased. Also, males show increased aggression and females show increased anxiety.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 12846 NCBI Gene Model | MGI Sequence Detail 19835 C57BL/6J ±  kb
    transcript NM_001111062 RefSeq | MGI Sequence Detail 2185 C57BL/6  
    polypeptide O88587 UniProt | EBI | MGI Sequence Detail 265 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 42
      Genomic 19
      cDNA 17
      Primer pair 5
      Other 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-2092, MGD-MRK-33988, MGI:106296, MGI:2441969
    References
    more
    • Summaries
      All 152
      Developmental Gene Expression 13
      Diseases 6
      Gene Ontology 12
      Phenotypes 97
    • Earliest
      J:14038 Bucan M, et al., Comparative mapping of 9 human chromosome 22q loci in the laboratory mouse. Hum Mol Genet. 1993 Aug;2(8):1245-52
    • Latest
      J:265457 Zamponi E, et al., Nrf2 stabilization prevents critical oxidative damage in Down syndrome cells. Aging Cell. 2018 Oct;17(5):e12812

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory