Comt
Gene Detail

Symbol Name ID

Comt catechol-O-methyltransferase MGI:88470

Synonyms

Comt1, D16Wsu103e, D330014B15Rik

Feature Type

protein coding gene

Genetic Map

Chromosome 16

11.40 cM
Detailed Genetic Map ± 1 cM


Mapping data(17)

Sequence Map

Chr16:18407346-18426852 bp, - strand From VEGA annotation of GRCm38   19507 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:30982  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: catechol O-methyltransferase, eukaryotic type
Gene Tree: Comt

Human homologs

Human Homolog		COMT, catechol-O-methyltransferase
NCBI Gene ID		1312
neXtProt AC		NX_P21964
Human Chr (Location)		22q11.21; chr22:19929263-19957498 (+)  GRCh37.p10
Disease Associations		(3) Diseases Associated with Human COMT

Alleles and phenotypes

All alleles(19) : Targeted(4) Gene trapped(14) Spontaneous(1)
 

Mice homozygous for disruption of this gene are viable, fertile, and show no gross or histological abnormalities. However dopamine levels in the frontal cortex of males are increased. Also, males show increased aggression and females show increased anxiety.

 
Human Diseases Modeled Using Mouse Comt (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (31 annotations)

Process	catecholamine metabolic process, catechol-containing compound metabolic process, ...
Component	cytoplasm, integral to membrane, ...
Function	catechol O-methyltransferase activity, magnesium ion binding, ...

External Resources: FuncBase

Expression

Literature Summary: (10 records)
Data Summary: Results (410)    Tissues (165)    Images (76)
Theiler Stages: 11, 16, 17, 19, 20, 22, 23, 24, 26, 28

Assay Type	Results
Immunohistochemistry	18
RNA in situ	314
RT-PCR	78

cDNA source data(13)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(39) Genomic(19) cDNA(15) Primer pair(5)
Microarray probesets(6)

Other database links

VEGA Gene Model	OTTMUSG00000026238 (Evidence)
Ensembl Gene Model	ENSMUSG00000000326 (Evidence)
Entrez Gene	12846 (Evidence)
DFCI	TC1577588, TC1611113, TC1640143, TC1651323, TC1674898, TC1706564
EC	2.1.1.6
Consensus CDS Project	CCDS28021.1
International Mouse Knockout Project Status	Comt

Sequences

Length	Strain/Species
genomic	OTTMUSG00000026238	VEGA Gene Model | MGI Sequence Detail	19507	C57BL/6J
transcript	OTTMUST00000064320	VEGA | MGI Sequence Detail	1786	Not Applicable
polypeptide	OTTMUSP00000031924	VEGA | MGI Sequence Detail	265	Not Applicable

All sequences(48) RefSeq(6) UniProt(2)

Polymorphisms

RFLP(2) : SNPs(143 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR025782	Catechol O-methyltransferase
InterPro	IPR017128	Catechol O-methyltransferase, eukaryotic
InterPro	IPR002935	O-methyltransferase, family 3
Protein Ontology	PR:000005731	catechol O-methyltransferase

References

(Earliest) J:14038 Bucan M, et al., Comparative mapping of 9 human chromosome 22q loci in the laboratory mouse. Hum Mol Genet. 1993 Aug;2(8):1245-52
(Latest) J:191130 Maynard TM, et al., 22q11 Gene dosage establishes an adaptive range for sonic hedgehog and retinoic acid signaling during early development. Hum Mol Genet. 2013 Jan 15;22(2):300-12
All references(82)

Other accession IDs

MGD-MRK-2092, MGD-MRK-33988, MGI:106296, MGI:2441969