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Comt Gene Detail
Summary
  • Symbol
    Comt
  • Name
    catechol-O-methyltransferase
  • Synonyms
    Comt1, D16Wsu103e, D330014B15Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:88470
    NCBI Gene: 12846
  • Alliance
  • Transcription Start Sites
    18 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:18225636-18245602 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 16, 11.40 cM
  • Mapping Data
    17 experiments
Strain
Comparison
more
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88470
protein coding gene Chr16:18225632-18247006 (-)
129S1/SvImJ MGP_129S1SvImJ_G0022610
protein coding gene Chr16:15632878-15652426 (-)
A/J MGP_AJ_G0022571
protein coding gene Chr16:14855746-14876689 (-)
AKR/J MGP_AKRJ_G0022548
protein coding gene Chr16:15447955-15468931 (-)
BALB/cJ MGP_BALBcJ_G0022576
protein coding gene Chr16:15004551-15025019 (-)
C3H/HeJ MGP_C3HHeJ_G0022343
protein coding gene Chr16:15597892-15617457 (-)
C57BL/6NJ MGP_C57BL6NJ_G0023025
protein coding gene Chr16:15906935-15934427 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020545
protein coding gene Chr16:14892116-14911372 (-)
CAST/EiJ MGP_CASTEiJ_G0021870
protein coding gene Chr16:15495388-15520848 (-)
CBA/J MGP_CBAJ_G0022312
protein coding gene Chr16:16618474-16643016 (-)
DBA/2J MGP_DBA2J_G0022444
protein coding gene Chr16:14772651-14792451 (-)
FVB/NJ MGP_FVBNJ_G0022419
protein coding gene Chr16:14828860-14848537 (-)
LP/J MGP_LPJ_G0022511
protein coding gene Chr16:15401400-15419673 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0022441
protein coding gene Chr16:16247722-16268854 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0023036
protein coding gene Chr16:15380398-15399977 (-)
PWK/PhJ MGP_PWKPhJ_G0021612
protein coding gene Chr16:15039239-15059840 (-)
SPRET/EiJ MGP_SPRETEiJ_G0021440
protein coding gene Chr16:15337358-15356473 (-)
WSB/EiJ MGP_WSBEiJ_G0021916
protein coding gene Chr16:15375259-15396025 (-)



Homology
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  • Human Ortholog
    COMT, catechol-O-methyltransferase
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    COMT, catechol-O-methyltransferase
  • Synonyms
    HEL-S-98n
  • Links
    NCBI Gene ID: 1312
    neXtProt AC: NX_P21964
    UniProt: P21964

  • Chr Location
    22q11.21; chr22:19941371-19969975 (+)  GRCh38

Human Diseases
more
  • Diseases
    2 with Comt mouse models; 30 with human COMT associations

Human Disease Mouse Models
      
IDs
View 1 model
      
IDs
View 1 model
      
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View 1 model
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Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    8 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    36 phenotypes from 5 alleles in 6 genetic backgrounds
    18 phenotypes from multigenic genotypes
    158 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruption of this gene are viable, fertile, and show no gross or histological abnormalities. However dopamine levels in the frontal cortex of males are increased. Also, males show increased aggression and females show increased anxiety.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000000326 Ensembl Gene Model | MGI Sequence Detail 19967 C57BL/6J ±  kb
    transcript ENSMUST00000000335 Ensembl | MGI Sequence Detail 1397 Not Applicable  
    polypeptide ENSMUSP00000000335 Ensembl | MGI Sequence Detail 265 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 42
      Genomic 19
      cDNA 17
      Primer pair 5
      Other 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-2092, MGD-MRK-33988, MGI:106296, MGI:2441969
    References
    more
    • Summaries
      All 216
      Developmental Gene Expression 17
      Diseases 8
      Gene Ontology 35
      Phenotypes 158
    • Earliest
      J:14038 Bucan M, et al., Comparative mapping of 9 human chromosome 22q loci in the laboratory mouse. Hum Mol Genet. 1993 Aug;2(8):1245-52
    • Latest
      J:342597 Rummell BP, et al., Altered corollary discharge signaling in the auditory cortex of a mouse model of schizophrenia predisposition. Nat Commun. 2023 Nov 15;14(1):7388

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    last database update
    03/12/2024
    MGI 6.23
    The Jackson Laboratory