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Comt
Gene Detail
Symbol

Name
ID
Comt
catechol-O-methyltransferase
MGI:88470
Synonyms
Comt1, D16Wsu103e, D330014B15Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 16
11.40 cM
Detailed Genetic Map ± 1 cM


Mapping data(17)
Sequence Map
Chr16:18407346-18426852 bp, - strand
From VEGA annotation of GRCm38

  19507 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:30982  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 3 western clawed frog

HCOP human homology predictions: COMT
Protein SuperFamily: catechol O-methyltransferase, eukaryotic type
Gene Tree: Comt

Human
homologs
COMT, catechol-O-methyltransferase
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 1312
neXtProt AC: NX_P21964

Human Synonyms: HEL-S-98n

Human Chr (Location): 22q11.21; chr22:19941740-19969975 (+)  GRCh38.p2

Disease Associations: (3) Diseases Associated with Human COMT

Mutations,
alleles, and
phenotypes
All mutations/alleles(28) : Gene trapped(14) Spontaneous(1) Targeted(12) Transgenic(1)
Genomic Mutations involving Comt (7)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for disruption of this gene are viable, fertile, and show no gross or histological abnormalities. However dopamine levels in the frontal cortex of males are increased. Also, males show increased aggression and females show increased anxiety.
 
Human Diseases Modeled in Mice Using Comt (1)    Mutations Annotated to Human Diseases (4)   
Interactions
Comt interacts with 128 markers (Mir15a, Mir20a, Mir29a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (42 annotations)
Process catecholamine metabolic process, catechol-containing compound metabolic process, ...
Component axon, cell body, ...
Function catechol O-methyltransferase activity, magnesium ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (11 records)
Data Summary: Results (411)    Tissues (168)    Images (77)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 19
RNA in situ 314
RT-PCR 78
cDNA source data(14)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA COMT ; Xenbase comt.2 ; ZFIN comta, comtb    NEW 
Molecular
reagents
All nucleic(40) Genomic(19) cDNA(16) Primer pair(5)
Microarray probesets(6)
Other database
links
VEGA Gene Model OTTMUSG00000026238 (Evidence)
Ensembl Gene Model ENSMUSG00000000326 (Evidence)
Entrez Gene 12846 (Evidence)
DFCI TC1577588, TC1611113, TC1640143, TC1651323, TC1674898, TC1706564
EC 2.1.1.6
PDB 4P7F, 4P58
Consensus CDS Project CCDS28021.1
International Mouse Phenotyping Consortium Status Comt
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000026238 VEGA Gene Model | MGI Sequence Detail 19507 C57BL/6J ±  kb
transcript OTTMUST00000064320 VEGA | MGI Sequence Detail 1786 Not Applicable 
polypeptide OTTMUSP00000031924 VEGA | MGI Sequence Detail 265 Not Applicable 

For the selected sequences
All sequences(50) RefSeq(6) UniProt(2)
Polymorphisms
RFLP(2) : SNPs within 2kb(158 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017128 Catechol O-methyltransferase, eukaryotic
InterPro IPR002935 O-methyltransferase, family 3
Protein Ontology PR:000005731 catechol O-methyltransferase
References
(Earliest) J:14038 Bucan M, et al., Comparative mapping of 9 human chromosome 22q loci in the laboratory mouse. Hum Mol Genet. 1993 Aug;2(8):1245-52
(Latest) J:213672 Herndon JM, et al., Catechol-o-methyltransferase and 3,4-({+/-})-methylenedioxymethamphetamine toxicity. Toxicol Sci. 2014 May;139(1):162-73
All references(87)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-2092, MGD-MRK-33988, MGI:106296, MGI:2441969

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/28/2015
MGI 5.22
The Jackson Laboratory