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Comt
Gene Detail
 Symbol
Name
ID
Comt
catechol-O-methyltransferase
MGI:88470
Synonyms Comt1, D16Wsu103e, D330014B15Rik
Feature Type protein coding gene
Genetic Map
Chromosome 16
11.40 cM
Detailed Genetic Map ± 1 cM


Mapping data(17)
Sequence Map
Chr16:18407346-18426852 bp, - strand
From VEGA annotation of GRCm38

  19507 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:30982  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Protein SuperFamily: catechol O-methyltransferase, eukaryotic type
Gene Tree: Comt

Human
homologs
Human Homolog COMT, catechol-O-methyltransferase
NCBI Gene ID 1312
neXtProt AC  NX_P21964
Human Synonyms  HEL-S-98n
Human Chr (Location)  22q11.21; chr22:19941740-19969975 (+)  GRCh38
Disease Associations  (3) Diseases Associated with Human COMT
Alleles
and
phenotypes
All alleles(19) : Gene trapped(14) Spontaneous(1) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for disruption of this gene are viable, fertile, and show no gross or histological abnormalities. However dopamine levels in the frontal cortex of males are increased. Also, males show increased aggression and females show increased anxiety.
 
Human Diseases Modeled Using Mouse Comt (1)    Alleles Annotated to Human Diseases(1)   
Gene Ontology
(GO)
classifications
All GO classifications: (42 annotations)
Process catecholamine metabolic process, catechol-containing compound metabolic process, ...
Component axon, cell body, ...
Function catechol O-methyltransferase activity, magnesium ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (10 records)
Data Summary: Results (410)    Tissues (165)    Images (76)
Theiler Stages: 11, 16, 17, 19, 20, 22, 23, 24, 26, 28
Assay TypeResults
Immunohistochemistry 18
RNA in situ 314
RT-PCR 78
cDNA source data(14)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(40) Genomic(19) cDNA(16) Primer pair(5)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000026238 (Evidence)
Ensembl Gene ModelENSMUSG00000000326 (Evidence)
Entrez Gene12846 (Evidence)
DFCITC1577588, TC1611113, TC1640143, TC1651323, TC1674898, TC1706564
EC2.1.1.6
Consensus CDS ProjectCCDS28021.1
International Mouse Knockout Project StatusComt
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000026238 VEGA Gene Model | MGI Sequence Detail 19507 C57BL/6J ±  kb
transcript OTTMUST00000064320 VEGA | MGI Sequence Detail 1786 Not Applicable 
polypeptide OTTMUSP00000031924 VEGA | MGI Sequence Detail 265 Not Applicable 

For the selected sequences
All sequences(50) RefSeq(6) UniProt(2)
Polymorphisms RFLP(2) : SNPs within 2kb(158 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR025782 Catechol O-methyltransferase
InterPro IPR017128 Catechol O-methyltransferase, eukaryotic
InterPro IPR002935 O-methyltransferase, family 3
Protein Ontology PR:000005731 catechol O-methyltransferase
References (Earliest) J:14038 Bucan M, et al., Comparative mapping of 9 human chromosome 22q loci in the laboratory mouse. Hum Mol Genet. 1993 Aug;2(8):1245-52
(Latest) J:204677 Zhang MZ, et al., Role of epoxyeicosatrienoic acids (EETs) in mediation of dopamine's effects in the kidney. Am J Physiol Renal Physiol. 2013 Dec 15;305(12):F1680-6
All references(87)
Other
accession IDs
MGD-MRK-2092, MGD-MRK-33988, MGI:106296, MGI:2441969

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory