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Targeted Allele Detail
Symbol: Del(16Dgcr2-Hira)3Aam
Name: deletion, Chr 16, Alea A Mills 3
MGI ID: MGI:3798964
Synonyms: Del(16)2Aam, Del(16Dgcr2-Hira)2Aam, Del3Aam, Df(16)A
Gene: Del(16Dgcr2-Hira)3Aam  Location: Chr16:17658219-18789059 bp  Genetic Position: Chr16, Syntenic
Germline Transmission:  Earliest citation of germline transmission: J:136969
Parent Cell Line:  AB2.2 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprt1b-m2
Allele Type:    Targeted (Null/knockout)
Mutations:    Intergenic deletion, Intragenic deletion
  Del(16Dgcr2-Hira)3Aam involves 51 genes/genome features (Gm26219, Gm26170, Gm15954 ...) View all
Mutation detailsCre-mediated recombination between a loxP site inserted into Dgcr2 (Dgcr2tm1Aam) and one in Hira (Hiratm1Aam) removes 1.3 Mb of sequence containing 27 genes (Dgcr2, Tssk1, Tssk2, Es2el, Gsc2, Slc25a1, Vpreb2, Dgcr6, Prodh, Rtn4r, Zdhhc8, Ranbp1, Htf9c, Dgcr8, D16H22S680E, Arvcf, Comt, Txnrd2, Gnb1l, Tbx1, Gp1bb, Sept5, Cldn5, Cdc45l, Ufd1l, Mrpl40 and Hira). (J:136969)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Mice Carrying this Mutation: 3 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation: 2 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Del(16Dgcr2-Hira)3Aam Mutation:  0 strains or lines available
Original:  J:136969 Stark KL, et al., Altered brain microRNA biogenesis contributes to phenotypic deficits in a 22q11-deletion mouse model. Nat Genet. 2008 Jun;40(6):751-60
All:  19 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.13
The Jackson Laboratory