Del(16Dgcr2-Hira)3Aam Cytogenetic Marker Detail

Summary

• Symbol
  Del(16Dgcr2-Hira)3Aam
• Name
  deletion, Chr 16, Alea A Mills 3
• Synonyms
  Del(16)2Aam, Del2Aam, Df(16)A

• Feature Type
  chromosomal deletion
• IDs
  MGI:3798957

Location &
Maps

• Sequence Map
  Genome coordinates not available from the current reference assembly.

• Genetic Map
  Chromosome 16, Syntenic

Human Diseases

• Diseases
  2 with Del(16Dgcr2-Hira)3Aam mouse models

Human Disease

Mouse Models

DiGeorge syndrome

IDs

DiGeorge syndrome      

DOID:11198
ICD10CM:D82.1
ICD9CM:279.11
MESH:D004062
NCI:C2989
OMIM:188400
UMLS_CUI:C0012236

View 1 model

Mouse Models

Human Disease Modeled: DiGeorge syndrome

Allelic Composition	Genetic Background	Reference	Phenotypes
Del(16Dgcr2-Hira)3Aam/+	involves: 129S7/SvEvBrd	J:141432	View

schizophrenia

IDs

schizophrenia      

DOID:5419
DOID:14734
ICD10CM:F20
ICD9CM:295
ICD9CM:295.8
ICD9CM:295.80
ICD9CM:295.9
ICD9CM:295.90
MESH:D012559
NCI:C3362
OMIM:181500
UMLS_CUI:C0036341

View 1 model

Mouse Models

Human Disease Modeled: schizophrenia

Allelic Composition	Genetic Background	Reference	Phenotypes
Del(16Dgcr2-Hira)3Aam/+	involves: 129S7/SvEvBrd * C57BL/6J	J:158957	View

Click on a disease name to see all genes associated with that disease.

• Mutations/Alleles
  1 with disease annotations

• References
  2 with disease annotations

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  13 phenotypes from 1 allele in 3 genetic backgrounds
  21 phenotype references
  

• All Mutations and Alleles
  1
• Targeted
  1
• Find Mice (IMSR)
  0 strains or lines available

References

• Summaries
  All 22

  Diseases 2

  Phenotypes 21
• Earliest
  J:136969 Stark KL, et al., Altered brain microRNA biogenesis contributes to phenotypic deficits in a 22q11-deletion mouse model. Nat Genet. 2008 Jun;40(6):751-60
• Latest
  J:374652 Thakur P, et al., An antisense oligonucleotide-based strategy to ameliorate cognitive dysfunction in the 22q11.2 Deletion Syndrome. Elife. 2025 May 27;13