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Symbol
Name
ID

Comt
catechol-O-methyltransferase
MGI:88470

Phenotype annotations related to behavior/neurological

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Human Phenotypes	Negativism	Addictive alcohol use	Hyperactivity	Attention deficit hyperactivity disorder
Disease(s) Associated with COMT	Negativism	Addictive alcohol use	Hyperactivity	Attention deficit hyperactivity disorder
alcohol dependence
attention deficit hyperactivity disorder
schizophrenia

Mouse Phenotypes

behavior/neurological phenotype

abnormal behavior

abnormal cognition

abnormal associative learning

abnormal spatial working memory

abnormal temporal memory

cognitive inflexibility

increased aggression towards male mice

decreased anxiety-related response

decreased thigmotaxis

increased anxiety-related response

abnormal response to novel object

abnormal impulsive behavior control

increased grip strength

abnormal locomotor behavior

hyperactivity

Availability

Mouse Genotype

Comt^B2i/Comt^B2i

*

Comt^tm1.1Tunb/Comt^tm1.1Tunb

*

Comt^{tm1b(EUCOMM)Wtsi}/Comt^{tm1b(EUCOMM)Wtsi}

Comt^tm1Kara/Comt^tm1Kara

Comt^B2i/Comt⁺

*

Comt^tm1Kara/Comt⁺

Tg(Camk2a-tTA)1Mmay/0
Tg(tetO-Comt)1Kndl/0

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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