Comt Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Comt
catechol-O-methyltransferase
MGI:88470

39 phenotypes from 6 alleles in 7 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Comt^B2i/Comt⁺ Boulder heterogeneous stock	abnormal response to novel object	J:162759
Comt^B2i/Comt⁺ Boulder heterogeneous stock	normal behavior/neurological phenotype	J:162759
Comt^B2i/Comt^B2i Boulder heterogeneous stock	abnormal response to novel object	J:162759
Comt^B2i/Comt^B2i Boulder heterogeneous stock	normal behavior/neurological phenotype	J:162759
Comt^tm1.1Tunb/Comt^tm1.1Tunb B6J.129-Comt^tm1.1Tunb	abnormal cognition	J:269121
	abnormal impulsive behavior control	J:269121
	abnormal spatial working memory	J:269121
	normal behavior/neurological phenotype	J:269121
	cognitive inflexibility	J:269121
Comt^{tm1b(EUCOMM)Wtsi}/Comt^{tm1b(EUCOMM)Wtsi} C57BL/6N-Comt^{tm1b(EUCOMM)Wtsi}/H	abnormal behavior	J:211773
	abnormal locomotor behavior	J:211773
	decreased anxiety-related response	J:211773
	decreased circulating fructosamine level	J:211773
	decreased circulating serum albumin level	J:211773
	decreased circulating total protein level	J:211773
	decreased thigmotaxis	J:211773
	hyperactivity	J:211773
	increased circulating alanine transaminase level	J:211773
	increased circulating phosphate level	J:211773
	increased grip strength	J:211773
Comt^tm1Kara/Comt⁺ involves: 129S4/SvJaeSor	increased aggression towards male mice	J:49475
Comt^tm1Kara/Comt^tm1Kara B6.129S4-Comt^tm1Kara	abnormal xenobiotic pharmacokinetics	J:164057
Comt^tm1Kara/Comt^tm1Kara B6.129S4-Comt^tm1Kara	increased dopamine level	J:164057
Comt^tm1Kara/Comt^tm1Kara involves: 129S4/SvJaeSor	abnormal blood homeostasis	J:137276
	abnormal fertility/fecundity	J:137276
	abnormal homeostasis	J:137276
	abnormal maternal decidual layer morphology	J:137276
	abnormal placenta morphology	J:137276
	abnormal placenta vasculature	J:137276
	abnormal pregnancy	J:137276
	abnormal renal glomerulus morphology	J:137276
	abnormal spongiotrophoblast layer morphology	J:137276
	albuminuria	J:137276
	hypertension	J:137276
	hypoxia	J:137276
	increased anxiety-related response	J:49475
	increased dopamine level	J:49475
	increased interferon-gamma secretion	J:137276
	increased uterine NK cell number	J:137276
	short gestation period	J:137276
Comt^tm1Mkae/Comt^tm1Mkae involves: C57BL/6J	abnormal xenobiotic pharmacokinetics	J:164057
Tg(Camk2a-tTA)1Mmay/0 Tg(tetO-Comt)1Kndl/0 involves: 129S6/SvEvTac * C57BL/6J	abnormal associative learning	J:225566
	abnormal behavior	J:225566
	abnormal impulsive behavior control	J:225566
	abnormal synaptic dopamine release	J:225566
	abnormal temporal memory	J:225566

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23