Braf
Gene Detail

Symbol Name ID

Braf Braf transforming gene MGI:88190

Synonyms

9930012E13Rik, Braf2, Braf-2, D6Ertd631e

Feature Type

protein coding gene

Genetic Map

Chromosome 6

18.43 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)

Sequence Map

Chr6:39603237-39725463 bp, - strand From VEGA annotation of GRCm38   122227 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:3197  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: RAF proto-oncogene serine/threonine-protein kinase
Gene Tree: Braf

Human homologs

Human Homolog		BRAF, v-raf murine sarcoma viral oncogene homolog B1
NCBI Gene ID		673
neXtProt AC		NX_P15056
Human Synonyms		BRAF1, B-RAF1, NS7, RAFB1
Human Chr (Location)		7q34; chr7:140433812-140624564 (-)  GRCh37.p10
Disease Associations		(4) Diseases Associated with Human BRAF

Alleles and phenotypes

All alleles(39) : Targeted(16) Gene trapped(23)
 

Homozygous null embryos die during organogenesis, are smaller, have enlarged blood vessels, hemorrhaging, poor circulation, slow heartbeat and abnormal endothelial cell development.

 
Human Diseases Modeled Using Mouse Braf (2)    Alleles Annotated to Human Diseases(2)    Phenotype Images(1)

Gene Ontology (GO) classifications

All GO classifications: (42 annotations)

Process	activation of MAPKK activity, cellular response to calcium ion, ...
Component	cytoplasm, membrane, ...
Function	ATP binding, calcium ion binding, ...

External Resources: FuncBase

Expression

Literature Summary: (14 records)
Data Summary: Results (129)    Tissues (84)    Images (7)
Theiler Stages: 11, 15, 17, 19, 20, 21, 22, 23, 24, 25, 28

Assay Type	Results
RNA in situ	25
Northern blot	51
RT-PCR	53

cDNA source data(35)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(44) Genomic(4) cDNA(36) Primer pair(3) Other(1)
Microarray probesets(15)

Other database links

VEGA Gene Model	OTTMUSG00000035245 (Evidence)
Ensembl Gene Model	ENSMUSG00000002413 (Evidence)
Entrez Gene	109880 (Evidence)
DFCI	TC1585043, TC1594488, TC1612728, TC1612731, TC1615933, TC1632787, TC1634086, TC1639402, TC1654655, TC1705802, TC1716215
EC	2.7.11.1
Consensus CDS Project	CCDS39463.1
International Mouse Knockout Project Status	Braf

Sequences

Length	Strain/Species
genomic	OTTMUSG00000035245	VEGA Gene Model | MGI Sequence Detail	122227	C57BL/6J
transcript	OTTMUST00000089870	VEGA | MGI Sequence Detail	9728	Not Applicable
polypeptide	OTTMUSP00000049160	VEGA | MGI Sequence Detail	804	Not Applicable

All sequences(79) RefSeq(2) UniProt(5)

Polymorphisms

SNPs(445 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR020454	Diacylglycerol/phorbol-ester binding
InterPro	IPR017441	Protein kinase, ATP binding site
InterPro	IPR000719	Protein kinase, catalytic domain
InterPro	IPR002219	Protein kinase C-like, phorbol ester/diacylglycerol binding
InterPro	IPR011009	Protein kinase-like domain
InterPro	IPR003116	Raf-like Ras-binding
InterPro	IPR008271	Serine/threonine-protein kinase, active site
InterPro	IPR001245	Serine-threonine/tyrosine-protein kinase catalytic domain
Protein Ontology	PR:000004801	B-Raf proto-oncogene serine/threonine-protein kinase

References

(Earliest) J:31016 Ikawa S, et al., B-raf, a new member of the raf family, is activated by DNA rearrangement. Mol Cell Biol. 1988 Jun;8(6):2651-4
(Latest) J:193498 Burd CE, et al., Monitoring tumorigenesis and senescence in vivo with a p16(INK4a)-luciferase model. Cell. 2013 Jan 17;152(1-2):340-51
All references(104)

Other accession IDs

MGD-MRK-1618, MGD-MRK-1619, MGD-MRK-1621, MGI:1277149, MGI:2141786, MGI:2442536, MGI:3034546, MGI:3034892, MGI:3034940