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Braf
Gene Detail
Symbol

Name
ID
Braf
Braf transforming gene
MGI:88190
Synonyms
9930012E13Rik, Braf2, Braf-2, D6Ertd631e
Feature Type
protein coding gene
Genetic Map
Chromosome 6
18.43 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr6:39603237-39725463 bp, - strand
From VEGA annotation of GRCm38

  122227 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3197  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: RAF proto-oncogene serine/threonine-protein kinase
Gene Tree: Braf

Human
homologs
Human Homolog BRAF, B-Raf proto-oncogene, serine/threonine kinase
NCBI Gene ID 673
neXtProt AC  NX_P15056
Human Synonyms  BRAF1, B-RAF1, NS7, RAFB1
Human Chr (Location)  7q34; chr7:140719334-140924764 (-)  GRCh38
Disease Associations  (4) Diseases Associated with Human BRAF
Mutations,
alleles, and
phenotypes
All mutations/alleles(43) : Gene trapped(23) Targeted(20)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null embryos die during organogenesis, are smaller, have enlarged blood vessels, hemorrhaging, poor circulation, slow heartbeat and abnormal endothelial cell development. Mice homozygous for a targeted allele activated in neurons exhibit impaired neuronal differentiation.
 
Human Diseases Modeled Using Mouse Braf (3)    Alleles Annotated to Human Diseases(2)    Phenotype Images(4)
Interactions
Braf interacts with 538 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (68 annotations)
Process activation of MAPKK activity, alpha-beta T cell differentiation, ...
Component cell body, cytoplasm, ...
Function ATP binding, calcium ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (17 records)
Data Summary: Results (129)    Tissues (84)    Images (8)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 25
Northern blot 51
RT-PCR 53
cDNA source data(35)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(44) Genomic(4) cDNA(36) Primer pair(3) Other(1)
Microarray probesets(15)
Other database
links
VEGA Gene ModelOTTMUSG00000035245 (Evidence)
Ensembl Gene ModelENSMUSG00000002413 (Evidence)
Entrez Gene109880 (Evidence)
DFCITC1585043, TC1594488, TC1612728, TC1612731, TC1615933, TC1632787, TC1634086, TC1639402, TC1654655, TC1705802, TC1716215
EC2.7.11.1
Consensus CDS ProjectCCDS39463.1
International Mouse Knockout Project StatusBraf
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000035245 VEGA Gene Model | MGI Sequence Detail 122227 C57BL/6J ±  kb
transcript OTTMUST00000089870 VEGA | MGI Sequence Detail 9728 Not Applicable 
polypeptide OTTMUSP00000049160 VEGA | MGI Sequence Detail 804 Not Applicable 

For the selected sequences
All sequences(105) RefSeq(24) UniProt(9)
Polymorphisms
SNPs within 2kb(478 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR020454 Diacylglycerol/phorbol-ester binding
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol binding
InterPro IPR011009 Protein kinase-like domain
InterPro IPR003116 Raf-like Ras-binding
InterPro IPR008271 Serine/threonine-protein kinase, active site
InterPro IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
Protein Ontology PR:000004801 B-Raf proto-oncogene serine/threonine-protein kinase
References
(Earliest) J:31016 Ikawa S, et al., B-raf, a new member of the raf family, is activated by DNA rearrangement. Mol Cell Biol. 1988 Jun;8(6):2651-4
(Latest) J:214355 Scortegagna M, et al., Genetic inactivation or pharmacological inhibition of Pdk1 delays development and inhibits metastasis of Braf(V600E)::Pten(-/-) melanoma. Oncogene. 2014 Aug 21;33(34):4330-9
All references(140)
Disease annotation references (3)
Other
accession IDs
MGD-MRK-1618, MGD-MRK-1619, MGD-MRK-1621, MGI:1277149, MGI:2141786, MGI:2442536, MGI:3034546, MGI:3034892, MGI:3034940

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory