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Braf
Gene Detail
Symbol

Name
ID
Braf
Braf transforming gene
MGI:88190
Synonyms
9930012E13Rik, Braf2, Braf-2, D6Ertd631e
Feature Type
protein coding gene
Genetic Map
Chromosome 6
18.43 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr6:39603237-39725463 bp, - strand
From VEGA annotation of GRCm38

  122227 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3197  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: BRAF
Protein SuperFamily: RAF proto-oncogene serine/threonine-protein kinase
Gene Tree: Braf

Human
homologs
BRAF, B-Raf proto-oncogene, serine/threonine kinase
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 673
neXtProt AC: NX_P15056

Human Synonyms: BRAF1, B-RAF1, NS7, RAFB1

Human Chr (Location): 7q34; chr7:140715951-140924764 (-)  GRCh38.p2

Disease Associations: (5) Diseases Associated with Human BRAF

Mutations,
alleles, and
phenotypes
All mutations/alleles(46) : Gene trapped(23) Targeted(22) Transgenic(1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygous null embryos die during organogenesis, are smaller, have enlarged blood vessels, hemorrhaging, poor circulation, slow heartbeat and abnormal endothelial cell development. Mice homozygous for a targeted allele activated in neurons exhibit impaired neuronal differentiation.
 
Human Diseases Modeled in Mice Using Braf (1)    Mutations Annotated to Human Diseases (3)    Phenotype Images(4)
Interactions
Braf interacts with 537 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (75 annotations)
Process activation of MAPKK activity, alpha-beta T cell differentiation, ...
Component cell body, cytoplasm, ...
Function ATP binding, calcium ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (20 records)
Data Summary: Results (129)    Tissues (84)    Images (8)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 25
Northern blot 51
RT-PCR 53
cDNA source data(35)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase braf ; ZFIN braf    NEW 
Molecular
reagents
All nucleic(44) Genomic(4) cDNA(36) Primer pair(3) Other(1)
Microarray probesets(15)
Other database
links
VEGA Gene Model OTTMUSG00000035245 (Evidence)
Ensembl Gene Model ENSMUSG00000002413 (Evidence)
Entrez Gene 109880 (Evidence)
DFCI TC1585043, TC1594488, TC1612728, TC1612731, TC1615933, TC1632787, TC1634086, TC1639402, TC1654655, TC1705802, TC1716215
EC 2.7.11.1
Consensus CDS Project CCDS39463.1
International Mouse Phenotyping Consortium Status Braf
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000035245 VEGA Gene Model | MGI Sequence Detail 122227 C57BL/6J ±  kb
transcript OTTMUST00000089870 VEGA | MGI Sequence Detail 9728 Not Applicable 
polypeptide OTTMUSP00000049160 VEGA | MGI Sequence Detail 804 Not Applicable 

For the selected sequences
All sequences(101) RefSeq(24) UniProt(5)
Polymorphisms
SNPs within 2kb(478 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR020454 Diacylglycerol/phorbol-ester binding
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol binding
InterPro IPR011009 Protein kinase-like domain
InterPro IPR003116 Raf-like Ras-binding
InterPro IPR008271 Serine/threonine-protein kinase, active site
InterPro IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
Protein Ontology PR:000004801 B-Raf proto-oncogene serine/threonine-protein kinase
References
(Earliest) J:31016 Ikawa S, et al., B-raf, a new member of the raf family, is activated by DNA rearrangement. Mol Cell Biol. 1988 Jun;8(6):2651-4
(Latest) J:220023 Perna D, et al., BRAF inhibitor resistance mediated by the AKT pathway in an oncogenic BRAF mouse melanoma model. Proc Natl Acad Sci U S A. 2015 Feb 10;112(6):E536-45
All references(150)
Disease annotation references (4)
Other
accession IDs
MGD-MRK-1618, MGD-MRK-1619, MGD-MRK-1621, MGI:1277149, MGI:2141786, MGI:2442536, MGI:3034546, MGI:3034892, MGI:3034940

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory