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Phenotypes Associated with This Genotype
Genotype
MGI:6192274
Allelic
Composition
Braftm1Mmcm/Braftm1Mmcm
Cd207tm2.1(cre)Bjec/Cd207+
Genetic
Background
involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Braftm1Mmcm mutation (3 available); any Braf mutation (58 available)
Cd207tm2.1(cre)Bjec mutation (0 available); any Cd207 mutation (25 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• increase in number of mainly MHC II+CD11c+ dendritic cells in the liver
• however, the number of dendritic cells in the lung and total numbers of macrophages, NK cells, B cells, and T cells are unaffected and mice do not exhibit anemia or alternation of circulating blood dendritic cells numbers

immune system
• increase in number of mainly MHC II+CD11c+ dendritic cells in the liver
• however, the number of dendritic cells in the lung and total numbers of macrophages, NK cells, B cells, and T cells are unaffected and mice do not exhibit anemia or alternation of circulating blood dendritic cells numbers
• by 12 weeks of age, mice develop small inflammatory infiltrates mainly to the liver that progressively increase in size with age
• by 20 weeks of age, all mice show small lesions in the lung

liver/biliary system
• by 12 weeks of age, mice develop small inflammatory infiltrates mainly to the liver that progressively increase in size with age

respiratory system
• by 20 weeks of age, all mice show small lesions in the lung

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
Langerhans-cell histiocytosis DOID:2571 OMIM:246400
OMIM:604856
J:211690


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
06/12/2024
MGI 6.13
The Jackson Laboratory