Ar
Gene Detail

Symbol Name ID

Ar androgen receptor MGI:88064

Feature Type

protein coding gene

Genetic Map

Chromosome X

42.82 cM
Detailed Genetic Map ± 1 cM


Mapping data(33)

Sequence Map

ChrX:98149721-98323215 bp, + strand From VEGA annotation of GRCm38   173495 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:28  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Protein SuperFamily: androgen receptor
Gene Tree: Ar

Human homologs

Human Homolog		AR, androgen receptor
NCBI Gene ID		367
neXtProt AC		NX_P10275
Human Synonyms		AIS, DHTR, HUMARA, HYSP1, KD, NR3C4, SBMA, SMAX1, TFM
Human Chr (Location)		Xq12; chrX:66763874-66950461 (+)  GRCh37.p10
Disease Associations		(5) Diseases Associated with Human AR

Alleles and phenotypes

All alleles(22) : Targeted(19) Spontaneous(3)
 

Hemizygous mutant males are androgen-resistant and therefore have small, undescended testes, and lack epididymal structures, vas deferens, and male accessory glands. They resemble females physically and behaviorally, but lack female reproductive organs.

 
Human Diseases Modeled Using Mouse Ar (4)    Alleles Annotated to Human Diseases(9)    Phenotype Images(4)

Gene Ontology (GO) classifications

All GO classifications: (96 annotations)

Process	activation of prostate induction by androgen receptor signaling pathway, androgen receptor signaling pathway, ...
Component	axon, cytoplasm, ...
Function	androgen binding, androgen receptor activity, ...

External Resources: FuncBase

Expression

Literature Summary: (47 records)
Data Summary: Results (185)    Tissues (151)    Images (32)
Theiler Stages: 19, 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
Immunohistochemistry	16
RNA in situ	148
RT-PCR	21

cDNA source data(22)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(51) Genomic(14) cDNA(26) Primer pair(7) Other(4)
Microarray probesets(6)

Other database links

VEGA Gene Model	OTTMUSG00000018072 (Evidence)
Ensembl Gene Model	ENSMUSG00000046532 (Evidence)
Entrez Gene	11835 (Evidence)
DFCI	TC1588979, TC1605269, TC1611475
DoTS	DT.101716332, DT.111022595, DT.482461
NIA Mouse Gene Index	U020040
PDB	2QPY
Consensus CDS Project	CCDS30294.1
International Mouse Knockout Project Status	Ar

Sequences

Length	Strain/Species
genomic	OTTMUSG00000018072	VEGA Gene Model | MGI Sequence Detail	173495	C57BL/6J
transcript	OTTMUST00000043610	VEGA | MGI Sequence Detail	9096	Not Applicable
polypeptide	OTTMUSP00000019597	VEGA | MGI Sequence Detail	899	Not Applicable

All sequences(37) RefSeq(2) UniProt(1)

Polymorphisms

All PCR and RFLP(7) : PCR(2) RFLP(5) SNPs(420 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001103	Androgen receptor
InterPro	IPR008946	Nuclear hormone receptor, ligand-binding
InterPro	IPR000536	Nuclear hormone receptor, ligand-binding, core
InterPro	IPR013088	Zinc finger, NHR/GATA-type
InterPro	IPR001628	Zinc finger, nuclear hormone receptor-type
Protein Ontology	PR:000004191	androgen receptor

References

(Earliest) J:13049 Gruneberg H, Genetical studies on the skeleton of the mouse. XVIII. Three genes for syndactylism. J Genet. 1956;54:113-145
(Latest) J:195340 Hsu JW, et al., Decreased tumorigenesis and mortality from bladder cancer in mice lacking urothelial androgen receptor. Am J Pathol. 2013 May;182(5):1811-20
All references(344)

Other accession IDs

MGD-MRK-1384, MGD-MRK-15046, MGI:2148007