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Ar
Gene Detail
Symbol

Name
ID
Ar
androgen receptor
MGI:88064
Feature Type
protein coding gene
Genetic Map
Chromosome X
42.82 cM
Detailed Genetic Map ± 1 cM


Mapping data(33)
Sequence Map
ChrX:98149721-98323215 bp, + strand
From VEGA annotation of GRCm38

  173495 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:28  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

HCOP human homology predictions: AR
Protein SuperFamily: androgen receptor
Gene Tree: Ar

Human
homologs
AR, androgen receptor
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 367
neXtProt AC: NX_P10275

Human Synonyms: AIS, AR8, DHTR, HUMARA, HYSP1, KD, NR3C4, SBMA, SMAX1, TFM

Human Chr (Location): Xq12; chrX:67544032-67730619 (+)  GRCh38.p2

Disease Associations: (5) Diseases Associated with Human AR

Mutations,
alleles, and
phenotypes
All mutations/alleles(34) : Endonuclease-mediated(1) Spontaneous(3) Targeted(20) Transgenic(10)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Hemizygous mutant males are androgen-resistant and therefore have small, undescended testes, and lack epididymal structures, vas deferens, and male accessory glands. They resemble females physically and behaviorally, but lack female reproductive organs.
 
Human Diseases Modeled in Mice Using Ar (3)    Mutations Annotated to Human Diseases (16)    Phenotype Images(4)
Interactions
Ar interacts with 504 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (57 records)
Data Summary: Results (191)    Tissues (152)    Images (38)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 22
RNA in situ 148
RT-PCR 21
cDNA source data(22)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase ar ; ZFIN ar    NEW 
Molecular
reagents
All nucleic(51) Genomic(14) cDNA(26) Primer pair(7) Other(4)
Microarray probesets(6)
Other database
links
VEGA Gene Model OTTMUSG00000018072 (Evidence)
Ensembl Gene Model ENSMUSG00000046532 (Evidence)
Entrez Gene 11835 (Evidence)
DFCI TC1588979, TC1605269, TC1611475
DoTS DT.101716332, DT.111022595, DT.482461
NIA Mouse Gene Index U020040
PDB 2QPY
Consensus CDS Project CCDS30294.1
International Mouse Phenotyping Consortium Status Ar
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000018072 VEGA Gene Model | MGI Sequence Detail 173495 C57BL/6J ±  kb
transcript OTTMUST00000043610 VEGA | MGI Sequence Detail 9096 Not Applicable 
polypeptide OTTMUSP00000019597 VEGA | MGI Sequence Detail 899 Not Applicable 

For the selected sequences
All sequences(37) RefSeq(2) UniProt(1)
Polymorphisms
All PCR and RFLP(7) : PCR(2) RFLP(5) SNPs within 2kb(495 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001103 Androgen receptor
InterPro IPR000536 Nuclear hormone receptor, ligand-binding domain
InterPro IPR013088 Zinc finger, NHR/GATA-type
InterPro IPR001628 Zinc finger, nuclear hormone receptor-type
Protein Ontology PR:000004191 androgen receptor
References
(Earliest) J:13049 Gruneberg H, Genetical studies on the skeleton of the mouse. XVIII. Three genes for syndactylism. J Genet. 1956;54:113-145
(Latest) J:223361 Kaftanovskaya EM, et al., Genetic ablation of androgen receptor signaling in fetal Leydig cell lineage affects Leydig cell functions in adult testis. FASEB J. 2015 Jun;29(6):2327-37
All references(398)
Disease annotation references (9)
Other
accession IDs
MGD-MRK-1384, MGD-MRK-15046, MGI:2148007

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory