About   Help   FAQ
Ar Gene Detail
Summary
  • Symbol
    Ar
  • Name
    androgen receptor
  • Feature Type
    protein coding gene
  • IDs
    MGI:88064
    NCBI Gene: 11835
  • Gene Overview
    MyGene.info: AR
  • Alliance
Location & Maps
more
  • Sequence Map
    ChrX:98149721-98323215 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      173495 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome X, 42.82 cM
  • Mapping Data
    33 experiments
Homology
more
  • Human Ortholog
    AR, androgen receptor
  • Vertebrate Orthologs
    8
  • Human Ortholog
    AR, androgen receptor
    Orthology source: HGNC, HomoloGene
  • Synonyms
    AIS, AR8, DHTR, HUMARA, HYSP1, KD, NR3C4, SBMA, SMAX1, TFM
  • Links
    NCBI Gene ID: 367
    neXtProt AC: NX_P10275
    UniProt: P10275

  • Chr Location
    Xq12; chrX:67544032-67730619 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    3 with Ar mouse models; 5 with human AR associations

Human Disease Mouse Models
      
IDs
View 8 models
      
IDs
View 1 model
IDs
View 1 model
      
IDs
IDs
IDs
View 7 models
IDs
View 5 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    18 with disease annotations
  • References
    20 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    163 phenotypes from 16 alleles in 33 genetic backgrounds
    117 phenotypes from multigenic genotypes
    4 images
    285 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Hemizygous mutant males are androgen-resistant and therefore have small, undescended testes, and lack epididymal structures, vas deferens, and male accessory glands. They resemble females physically and behaviorally, but lack female reproductive organs.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000018072 VEGA Gene Model | MGI Sequence Detail 173495 C57BL/6J ±  kb
    transcript OTTMUST00000043610 VEGA | MGI Sequence Detail 9096 Not Applicable  
    polypeptide OTTMUSP00000019597 VEGA | MGI Sequence Detail 899 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      492 from dbSNP Build 142
    • PCR
    • RFLP
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 54
      Genomic 14
      cDNA 31
      Primer pair 7
      Other 2

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-1384, MGD-MRK-15046, MGI:2148007
    References
    more
    • Summaries
      All 519
      Developmental Gene Expression 74
      Diseases 20
      Gene Ontology 40
      Phenotypes 285
    • Earliest
      J:13049 Gruneberg H, Genetical studies on the skeleton of the mouse. XVIII. Three genes for syndactylism. J Genet. 1956;54:113-145
    • Latest
      J:263785 Xu Y, et al., Pre-clinical symptoms of SBMA may not be androgen-dependent: implications from two SBMA mouse models. Hum Mol Genet. 2018 Jul 15;27(14):2425-2442

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
    Warranty Disclaimer & Copyright Notice
    Send questions and comments to User Support.
    last database update
    09/11/2018
    MGI 6.12
    The Jackson Laboratory