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Ar Gene Detail
Summary
  • Symbol
    Ar
  • Name
    androgen receptor
  • Feature Type
    protein coding gene
  • IDs
    MGI:88064
    NCBI Gene: 11835
  • Gene Overview
    MyGene.info: AR
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:98148769-98323215 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome X, 42.82 cM
  • Mapping Data
    33 experiments
Strain
Comparison
more
  • SNPs within 2kb
    492 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88064
protein coding gene ChrX:98148757-98323218 (.)
129S1/SvImJ MGP_129S1SvImJ_G0035931
protein coding gene ChrX:94519451-94700407 (+)
A/J MGP_AJ_G0035916
protein coding gene ChrX:94631610-94809631 (+)
AKR/J MGP_AKRJ_G0035832
protein coding gene ChrX:97292110-97471900 (+)
BALB/cJ MGP_BALBcJ_G0035899
protein coding gene ChrX:93407432-93578928 (+)
C3H/HeJ MGP_C3HHeJ_G0035608
protein coding gene ChrX:94992285-95167427 (+)
C57BL/6NJ MGP_C57BL6NJ_G0036428
protein coding gene ChrX:97458294-97643128 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0033258
protein coding gene ChrX:92480947-92650344 (+)
CAST/EiJ MGP_CASTEiJ_G0034895
protein coding gene ChrX:79328711-79503668 (+)
CBA/J MGP_CBAJ_G0035583
protein coding gene ChrX:100460337-100628022 (+)
DBA/2J MGP_DBA2J_G0035737
protein coding gene ChrX:93888415-94059222 (+)
FVB/NJ MGP_FVBNJ_G0035675
protein coding gene ChrX:93271509-93443758 (+)
LP/J MGP_LPJ_G0035827
protein coding gene ChrX:95537760-95715093 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0035710
protein coding gene ChrX:104895192-105106596 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0036455
protein coding gene ChrX:94291304-94467544 (+)
PWK/PhJ MGP_PWKPhJ_G0034594
protein coding gene ChrX:77021615-77190976 (+)
SPRET/EiJ MGP_SPRETEiJ_G0034422
protein coding gene ChrX:80192320-80361924 (+)
WSB/EiJ MGP_WSBEiJ_G0035034
protein coding gene ChrX:92998626-93174570 (+)



Homology
more
  • Human Ortholog
    AR, androgen receptor
  • Vertebrate Orthologs
    8
  • Human Ortholog
    AR, androgen receptor
    Orthology source: HGNC, HomoloGene
  • Synonyms
    AIS, AR8, DHTR, HUMARA, HYSP1, KD, NR3C4, SBMA, SMAX1, TFM
  • Links
    NCBI Gene ID: 367
    neXtProt AC: NX_P10275
    UniProt: P10275

  • Chr Location
    Xq12; chrX:67544032-67730619 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    3 with Ar mouse models; 5 with human AR associations

Human Disease Mouse Models
      
IDs
View 8 models
      
IDs
View 1 model
IDs
View 1 model
      
IDs
IDs
IDs
View 7 models
IDs
View 5 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    18 with disease annotations
  • References
    20 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    163 phenotypes from 16 alleles in 33 genetic backgrounds
    117 phenotypes from multigenic genotypes
    4 images
    289 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Hemizygous mutant males are androgen-resistant and therefore have small, undescended testes, and lack epididymal structures, vas deferens, and male accessory glands. They resemble females physically and behaviorally, but lack female reproductive organs.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000046532 Ensembl Gene Model | MGI Sequence Detail 174447 C57BL/6J ±  kb
    transcript ENSMUST00000052837 Ensembl | MGI Sequence Detail 10048 Not Applicable  
    polypeptide ENSMUSP00000052648 Ensembl | MGI Sequence Detail 899 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 54
      Genomic 14
      cDNA 31
      Primer pair 7
      Other 2

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-1384, MGD-MRK-15046, MGI:2148007
    References
    more
    • Summaries
      All 522
      Developmental Gene Expression 75
      Diseases 20
      Gene Ontology 40
      Phenotypes 289
    • Earliest
      J:13049 Gruneberg H, Genetical studies on the skeleton of the mouse. XVIII. Three genes for syndactylism. J Genet. 1956;54:113-145
    • Latest
      J:266512 Berkel S, et al., Sex Hormones Regulate SHANK Expression. Front Mol Neurosci. 2018;11:337

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    12/11/2018
    MGI 6.13
    The Jackson Laboratory