Apoe
Gene Detail

Symbol Name ID

Apoe apolipoprotein E MGI:88057

STS

D7Mit57

Feature Type

protein coding gene

Genetic Map

Chromosome 7

9.94 cM
Detailed Genetic Map ± 1 cM


Mapping data(30)

Sequence Map

Chr7:19696109-19699166 bp, - strand From VEGA annotation of GRCm38   3058 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:30951  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 2 zebrafish

Gene Tree: Apoe

Human homologs

Human Homolog		APOE, apolipoprotein E
NCBI Gene ID		348
neXtProt AC		NX_P02649
Human Synonyms		AD2, LDLCQ5, LPG
Human Chr (Location)		19q13.2; chr19:45409039-45412650 (+)  GRCh37.p10
Disease Associations		(6) Diseases Associated with Human APOE

Alleles and phenotypes

All alleles(39) : Targeted(18) Gene trapped(19) Transgenic(1) Spontaneous(1)
 

Mutations at this locus cause diet-induced hypercholesterolemia and atherosclerosis. Homozygous null mutants also develop foam-cell rich deposits in proximal aorta, impaired blood-nerve and blood-brain barriers, and many xanthomatous lesions.

 
Human Diseases Modeled Using Mouse Apoe (2)    Alleles Annotated to Human Diseases(5)    Phenotype Images(10)

Gene Ontology (GO) classifications

All GO classifications: (105 annotations)

Process	aging, artery morphogenesis, ...
Component	chylomicron, cytoplasm, ...
Function	antioxidant activity, beta-amyloid binding, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (28 records)
Data Summary: Results (249)    Tissues (171)    Images (62)
Theiler Stages: 11, 13, 15, 17, 19, 20, 22, 23, 24, 28

Assay Type	Results
RNA in situ	169
Northern blot	30
RT-PCR	50

cDNA source data(1770)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(1782) Genomic(2) cDNA(1770) Primer pair(4) Other(6)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000038239 (Evidence)
Ensembl Gene Model	ENSMUSG00000002985 (Evidence)
Entrez Gene	11816 (Evidence)
UniGene	305152
DFCI	TC1573648, TC1687215
DoTS	DT.87073740, DT.91406850, DT.91569392, DT.94158372, DT.97395435, DT.97396088
NIA Mouse Gene Index	U028237
PDB	1YA9
Consensus CDS Project	CCDS20912.1
International Mouse Knockout Project Status	Apoe

Sequences

Length	Strain/Species
genomic	OTTMUSG00000038239	VEGA Gene Model | MGI Sequence Detail	3058	C57BL/6J
transcript	OTTMUST00000098459	VEGA | MGI Sequence Detail	1104	Not Applicable
polypeptide	OTTMUSP00000055347	VEGA | MGI Sequence Detail	311	Not Applicable

All sequences(93) RefSeq(2) UniProt(13)

Polymorphisms

RFLP(8) : SNPs(21 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR013326	Apolipoprotein
InterPro	IPR000074	Apolipoprotein A1/A4/E
Protein Ontology	PR:000004155	apolipoprotein E

References

(Earliest) J:5183 Forsthoefel PF, et al., Linkage relationships of Strong's luxoid gene in the mouse. J Hered. 1970 Mar-Apr;61(2):64-6
(Latest) J:196420 Ervinna N, et al., Anagliptin, a DPP-4 inhibitor, suppresses proliferation of vascular smooth muscles and monocyte inflammatory reaction and attenuates atherosclerosis in male apo E-deficient mice. Endocrinology. 2013 Mar;154(3):1260-70
All references(1479)

Other accession IDs

MGD-MRK-1376, MGI:2141887