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Apoe Gene Detail
Summary
  • Symbol
    Apoe
  • Name
    apolipoprotein E
  • Feature Type
    protein coding gene
  • IDs
    MGI:88057
    NCBI Gene: 11816
  • Gene Overview
    MyGene.info: APOE
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr7:19696109-19699188 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      3080 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 9.94 cM
  • Mapping Data
    30 experiments
  • Sequence Tag
Homology
more
  • Human Ortholog
    APOE, apolipoprotein E
  • Vertebrate Orthologs
    8
  • Human Ortholog
    APOE, apolipoprotein E
    Orthology source: HomoloGene, HGNC
  • Synonyms
    AD2, APO-E, ApoE4, LDLCQ5, LPG
  • Links
    NCBI Gene ID: 348
    neXtProt AC: NX_P02649
    UniProt: P02649

  • Chr Location
    19q13.32; chr19:44905749-44909395 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    4 with human APOE associations

Human Disease Mouse Models
      
IDs
View 1 model
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    12 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    163 phenotypes from 12 alleles in 26 genetic backgrounds
    291 phenotypes from multigenic genotypes
    15 images
    1852 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mutations at this locus cause diet-induced hypercholesterolemia and atherosclerosis. Homozygous null mutants also develop foam-cell rich deposits in proximal aorta, impaired blood-nerve and blood-brain barriers, and many xanthomatous lesions.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000038239 VEGA Gene Model | MGI Sequence Detail 3080 C57BL/6J ±  kb
    transcript OTTMUST00000098456 VEGA | MGI Sequence Detail 1408 Not Applicable  
    polypeptide OTTMUSP00000055344 VEGA | MGI Sequence Detail 311 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      47 from dbSNP Build 142
    • RFLP
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 1802
      Genomic 2
      cDNA 1790
      Primer pair 4
      Other 6

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-1376, MGI:2141887
    References
    more
    • Summaries
      All 2230
      Developmental Gene Expression 35
      Diseases 12
      Gene Ontology 32
      Phenotypes 1852
    • Earliest
      J:5183 Forsthoefel PF, et al., Linkage relationships of Strong's luxoid gene in the mouse. J Hered. 1970 Mar-Apr;61(2):64-6
    • Latest
      J:265192 Hikita T, et al., PAR-3 controls endothelial planar polarity and vascular inflammation under laminar flow. EMBO Rep. 2018 Sep;19(9)

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    10/09/2018
    MGI 6.12
    The Jackson Laboratory