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Apoe
Gene Detail
Symbol

Name
ID
Apoe
apolipoprotein E
MGI:88057
STS
Feature Type
protein coding gene
Genetic Map
Chromosome 7
9.94 cM
Detailed Genetic Map ± 1 cM


Mapping data(30)
Sequence Map
Chr7:19696109-19699166 bp, - strand
From VEGA annotation of GRCm38

  3058 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:30951  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog

Gene Tree: Apoe

Human
homologs
Human Homolog APOE, apolipoprotein E
NCBI Gene ID 348
neXtProt AC  NX_P02649
Human Synonyms  AD2, APO-E, LDLCQ5, LPG
Human Chr (Location)  19q13.2; chr19:44905782-44909393 (+)  GRCh38
Disease Associations  (6) Diseases Associated with Human APOE
Mutations,
alleles, and
phenotypes
All mutations/alleles(40) : Gene trapped(19) Spontaneous(1) Targeted(19) Transgenic(1)
Incidental mutations (data from Mutagenetix , APF )
 
Mutations at this locus cause diet-induced hypercholesterolemia and atherosclerosis. Homozygous null mutants also develop foam-cell rich deposits in proximal aorta, impaired blood-nerve and blood-brain barriers, and many xanthomatous lesions.
 
Human Diseases Modeled Using Mouse Apoe (2)    Alleles Annotated to Human Diseases(5)    Phenotype Images(13)
Interactions
Apoe interacts with 57 markers (Mir1a-1, Mir1a-2, Mir34b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (29 records)
Data Summary: Results (249)    Tissues (171)    Images (62)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 169
Northern blot 30
RT-PCR 50
cDNA source data(1787)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(1799) Genomic(2) cDNA(1787) Primer pair(4) Other(6)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000038239 (Evidence)
Ensembl Gene ModelENSMUSG00000002985 (Evidence)
Entrez Gene11816 (Evidence)
UniGene305152
DFCITC1573648, TC1687215
DoTSDT.87073740, DT.91406850, DT.91569392, DT.94158372, DT.97395435, DT.97396088
NIA Mouse Gene IndexU028237
PDB1YA9
Consensus CDS ProjectCCDS20912.1
International Mouse Knockout Project StatusApoe
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000038239 VEGA Gene Model | MGI Sequence Detail 3058 C57BL/6J ±  kb
transcript OTTMUST00000098456 VEGA | MGI Sequence Detail 1386 Not Applicable 
polypeptide OTTMUSP00000055344 VEGA | MGI Sequence Detail 311 Not Applicable 

For the selected sequences
All sequences(107) RefSeq(4) UniProt(25)
Polymorphisms
RFLP(8) : SNPs within 2kb(47 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000074 Apolipoprotein A1/A4/E
Protein Ontology PR:000004155 apolipoprotein E
References
(Earliest) J:5183 Forsthoefel PF, et al., Linkage relationships of Strong's luxoid gene in the mouse. J Hered. 1970 Mar-Apr;61(2):64-6
(Latest) J:214859 Klein RC, et al., Altered neurotransmission in the lateral amygdala in aged human apoE4 targeted replacement mice. Neurobiol Aging. 2014 Sep;35(9):2046-52
All references(1631)
Disease annotation references (9)
Other
accession IDs
MGD-MRK-1376, MGI:2141887

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/16/2014
MGI 5.20
The Jackson Laboratory