Clu^tm1Jakh
Targeted Allele Detail

Summary

• Symbol: Clu^tm1Jakh
• Name: clusterin; targeted mutation 1, Judith A K Harmony
• MGI ID: MGI:2181011
• Synonyms: CLU^-
• Gene: Clu Location: Chr14:66205932-66218996 bp, + strand Genetic Position: Chr14, 34.36 cM
• Alliance: Clu^tm1Jakh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:65660
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: An HPRT cassette replaced exons 1 and 2. Normal transcript was undetectable in homozygous mutant tissue. Western blot analysis of plasma and liver extracts showed an absence of protein in homozygous mutant mice. (J:2892, J:65660, J:67960)

Disease models

Expression

In Mice Carrying this Mutation:	11 assay results
In Structures Affected by this Mutation:	7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Clu Mutation: 31 strains or lines available

References

• Original: J:65660 McLaughlin L, et al., Apolipoprotein J/clusterin limits the severity of murine autoimmune myocarditis. J Clin Invest. 2000 Nov;106(9):1105-13
• All: 42 reference(s)