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Clu Gene Detail
Summary
  • Symbol
    Clu
  • Name
    clusterin
  • Synonyms
    ApoJ, Apolipoprotein J, Cli, complement lysis inhibitor, D14Ucla3, Sgp-2, Sgp2, SP-40, Sugp-2, testosterone repressed prostate message-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:88423
    NCBI Gene: 12759
  • Alliance
  • Transcription Start Sites
    59 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:66206093-66218992 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 14, 34.36 cM
  • Mapping Data
    16 experiments
Strain
Comparison
more
  • SNPs within 2kb
    417 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88423
protein coding gene Chr14:66205932-66218996 (+)
129S1/SvImJ MGP_129S1SvImJ_G0021488
protein coding gene Chr14:60610719-60623779 (+)
A/J MGP_AJ_G0021447
protein coding gene Chr14:59192551-59205610 (+)
AKR/J MGP_AKRJ_G0021423
protein coding gene Chr14:61245352-61258411 (+)
BALB/cJ MGP_BALBcJ_G0021453
protein coding gene Chr14:59134321-59147380 (+)
C3H/HeJ MGP_C3HHeJ_G0021230
protein coding gene Chr14:60922990-60938591 (+)
C57BL/6NJ MGP_C57BL6NJ_G0021892
protein coding gene Chr14:63403013-63416071 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019432
protein coding gene Chr14:57112529-57125546 (+)
CAST/EiJ MGP_CASTEiJ_G0020747
protein coding gene Chr14:57401272-57415815 (+)
CBA/J MGP_CBAJ_G0021197
protein coding gene Chr14:65319887-65332964 (+)
DBA/2J MGP_DBA2J_G0021320
protein coding gene Chr14:58839524-58852580 (+)
FVB/NJ MGP_FVBNJ_G0021299
protein coding gene Chr14:58249960-58263018 (+)
LP/J MGP_LPJ_G0021395
protein coding gene Chr14:61650603-61665487 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0021328
protein coding gene Chr14:64396226-64412210 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0021915
protein coding gene Chr14:60446198-60459256 (+)
PWK/PhJ MGP_PWKPhJ_G0020491
protein coding gene Chr14:55567043-55580304 (+)
SPRET/EiJ MGP_SPRETEiJ_G0020324
protein coding gene Chr14:56414688-56429135 (+)
WSB/EiJ MGP_WSBEiJ_G0020800
protein coding gene Chr14:60738247-60753374 (+)



Homology
more
  • Human Ortholog
    CLU, clusterin
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CLU, clusterin
  • Synonyms
    AAG4, APO-J, APOJ, CLI, CLU1, CLU2, KUB1, NA1/NA2, SGP-2, SGP2, SP-40, TRPM-2, TRPM2
  • Links
    NCBI Gene ID: 1191
    neXtProt AC: NX_P10909
    UniProt: P10909

  • Chr Location
    8p21.1; chr8:27596917-27614700 (-)  GRCh38

Human Diseases
more
  • Diseases
    9 with human CLU associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    24 phenotypes from 2 alleles in 4 genetic backgrounds
    5 phenotypes from multigenic genotypes
    63 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous inactivation of this gene leads to progressive renal glomerulopathy and increased severity of myosin-induced autoimmune myocarditis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 12759 NCBI Gene Model | MGI Sequence Detail 12900 C57BL/6J ±  kb
    transcript NM_001422221 RefSeq | MGI Sequence Detail 1772 ZRU/MplStud  
    polypeptide Q06890 UniProt | EBI | MGI Sequence Detail 448 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 596
      Genomic 4
      cDNA 578
      Primer pair 10
      Other 4

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-14642, MGD-MRK-2016, MGD-MRK-2022, MGD-MRK-3968, MGI:2145707, MGI:90170
    References
    more
    • Summaries
      All 204
      Developmental Gene Expression 53
      Diseases 2
      Gene Ontology 14
      Phenotypes 63
    • Earliest
      J:17167 Jenne DE, et al., Molecular structure and functional characterization of a human complement cytolysis inhibitor found in blood and seminal plasma: identity to sulfated glycoprotein 2, a constituent of rat testis fluid. Proc Natl Acad Sci U S A. 1989 Sep;86(18):7123-7
    • Latest
      J:352542 Kirk JS, et al., Integrated single-cell analysis defines the epigenetic basis of castration-resistant prostate luminal cells. Cell Stem Cell. 2024 Jun 14;

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    last database update
    10/01/2024
    MGI 6.24
    The Jackson Laboratory