Symbol
Name
ID

Apoe
apolipoprotein E
MGI:88057

Phenotype annotations related to homeostasis/metabolism

*	Aspects of the system are reported to show a normal phenotype.
!	Indicates phenotype varies with strain background.
	Darker colors indicate more annotations

Human Phenotypes

Increased circulating IgA level

Increased circulating IgG level

Decreased circulating antibody level

Paraproteinemia

Abnormality of metabolism/homeostasis

Hypercalcemia

Hyperbilirubinemia

Increased LDL cholesterol concentration

Increased VLDL cholesterol concentration

Hypercholesterolemia

Hyperlipidemia

Hypertriglyceridemia

Elevated circulating creatinine concentration

Elevated circulating apolipoprotein A-II concentration

Elevated circulating apolipoprotein B concentration

Elevated circulating C-reactive protein concentration

Hyperproteinemia

Elevated circulating alanine aminotransferase concentration

Elevated circulating aspartate aminotransferase concentration

Glucose intolerance

Diabetes mellitus

Type II diabetes mellitus

Impaired glucose tolerance

Pleural effusion

Fever

Food intolerance

Abnormality of vitamin B12 metabolism

Amyloidosis

Disease(s) Associated with APOE

atopic dermatitis

coronary artery disease

familial combined hyperlipidemia

malaria

multiple myeloma

sea-blue histiocytosis

Sjogren's syndrome

Mouse Phenotypes

homeostasis/metabolism phenotype

decreased cardiac muscle triglyceride level

increased cholesterol efflux

decreased circulating homocysteine level

decreased circulating glucose level

increased circulating corticosterone level

decreased circulating insulin level

decreased circulating leptin level

abnormal circulating lipid level

abnormal circulating cholesterol level

decreased circulating HDL cholesterol level

increased circulating HDL cholesterol level

abnormal circulating LDL cholesterol level

increased circulating LDL cholesterol level

increased circulating VLDL cholesterol level

decreased circulating cholesterol level

increased circulating cholesterol level

increased circulating phospholipid level

decreased circulating triglyceride level

increased circulating triglyceride level

hyperlipidemia

abnormal circulating protein level

abnormal circulating apolipoprotein E level

abnormal glomerular capillary thrombosis

abnormal nitric oxide homeostasis

improved glucose tolerance

increased insulin sensitivity

abnormal lipid homeostasis

abnormal cholesterol homeostasis

decreased liver cholesterol level

decreased cholesterol level

increased cholesterol level

abnormal lipid level

increased prostaglandin level

decreased liver triglyceride level

decreased skeletal muscle triglyceride level

decreased triglyceride level

increased triglyceride level

xanthoma

abnormal enzyme/coenzyme activity

abnormal nucleotide metabolism

decreased cerebral infarct size

Availability

Mouse Genotype

Apoe^shl/Apoe^shl

Apoe^{Tg(rtTA)1Gaga}/Apoe^{Tg(rtTA)1Gaga}

Apoe^tm1.1Khw/Apoe^tm1.1Khw

Apoe^tm1Bres/Apoe^tm1Bres

Apoe^tm1Khw/Apoe^tm1Khw

Apoe^tm1Lmh/Apoe^tm1Lmh

Apoe^tm1Unc/Apoe^tm1Unc

Apoe^tm1Unc/Apoe^tm1Unc
Tg(Cyp21a1-Apoe)614Fet/0

Apoe^tm1Unc/Apoe^tm1Unc
Tg(Cyp21a1-Apoe)619Fet/0

Apoe^tm4Mae/Apoe^tm4Mae

Apoe^shl/Apoe^tm1Unc

Apoe^tm1Bres/Apoe⁺

Apoe^tm1Lmh/Apoe⁺

Apoe^tm1Unc/Apoe⁺

Tg(Cyp21a1-Apoe)614Fet/0

Tg(Cyp21a1-Apoe)619Fet/0

Apoe^tm1.1Mae/Apoe^tm1.1Mae
Tg(Fabp4-cre)1Rev/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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