Phenotypes Associated with This Genotype

Genotype
MGI:4355230

• Allelic Composition: Apoe^{tm3(APOE*4)Mae}/Apoe^{tm3(APOE*4)Mae}; Tg(Thy1-APPSwDutIowa)BWevn/?
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal astrocyte morphology ( J:136318 )

• increased number of neuroreactive astrocytes in cortex

• decreased number of neuroreactive astrocytes in thalamic region

abnormal microglial cell morphology ( J:136318 )

• increased number of neuroreactive microglia in cortex

• decreased number of neuroreactive microglia in thalamic region

amyloid beta deposits ( J:136318 )

• plaque deposition in cortical parenchyma increased 20%

• reduced deposition in cerebral microvasculature

• microglia are tightly associated with parenchymal plaque amyloid

hematopoietic system

abnormal microglial cell morphology ( J:136318 )

• increased number of neuroreactive microglia in cortex

• decreased number of neuroreactive microglia in thalamic region

immune system

abnormal microglial cell morphology ( J:136318 )

• increased number of neuroreactive microglia in cortex

• decreased number of neuroreactive microglia in thalamic region

homeostasis/metabolism

amyloid beta deposits ( J:136318 )

• plaque deposition in cortical parenchyma increased 20%

• reduced deposition in cerebral microvasculature

• microglia are tightly associated with parenchymal plaque amyloid

cellular

abnormal astrocyte morphology ( J:136318 )

• increased number of neuroreactive astrocytes in cortex

• decreased number of neuroreactive astrocytes in thalamic region

abnormal microglial cell morphology ( J:136318 )

• increased number of neuroreactive microglia in cortex

• decreased number of neuroreactive microglia in thalamic region

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Alzheimer's disease		DOID:10652		J:136318