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Gck Gene Detail
Summary
  • Symbol
    Gck
  • Name
    glucokinase
  • Synonyms
    Gls006, hexokinase 4, HK4, Hlb62, MODY2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1270854
    NCBI Gene: 103988
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:5850820-5900081 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 3.88 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    97 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1270854
 protein coding gene Chr11:5850816-5900081 (-)
129S1/SvImJ MGP_129S1SvImJ_G0018012
 protein coding gene Chr11:2987565-3044533 (-)
A/J MGP_AJ_G0017985
 protein coding gene Chr11:2870713-2922435 (-)
AKR/J MGP_AKRJ_G0017949
 protein coding gene Chr11:3020092-3070946 (-)
BALB/cJ MGP_BALBcJ_G0017953
 protein coding gene Chr11:2863091-2910994 (-)
C3H/HeJ MGP_C3HHeJ_G0017766
 protein coding gene Chr11:2893851-2946268 (-)
C57BL/6NJ MGP_C57BL6NJ_G0018405
 protein coding gene Chr11:3070972-3123012 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016063
 protein coding gene Chr11:2770872-2820234 (-)
CAST/EiJ MGP_CASTEiJ_G0017328
 protein coding gene Chr11:2862845-2919185 (-)
CBA/J MGP_CBAJ_G0017741
 protein coding gene Chr11:3440853-3505866 (-)
DBA/2J MGP_DBA2J_G0017851
 protein coding gene Chr11:2777101-2827113 (-)
FVB/NJ MGP_FVBNJ_G0017843
 protein coding gene Chr11:2802183-2854053 (-)
LP/J MGP_LPJ_G0017922
 protein coding gene Chr11:3067041-3119602 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0017869
 protein coding gene Chr11:3038253-3104463 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0018445
 protein coding gene Chr11:3026120-3086654 (-)
PWK/PhJ MGP_PWKPhJ_G0017108
 protein coding gene Chr11:2802229-2851425 (-)
SPRET/EiJ MGP_SPRETEiJ_G0016905
 protein coding gene Chr11:2992503-3043524 (-)
WSB/EiJ MGP_WSBEiJ_G0017382
 protein coding gene Chr11:2866759-2919047 (-)



Homology
more
  • Human Ortholog
    GCK, glucokinase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GCK, glucokinase
  • Synonyms
    FGQTL3, GK, GLK, HHF3, HK4, HKIV, HXKP, LGLK, MODY2, PNDM1
  • Links
    NCBI Gene ID: 2645
    neXtProt AC: NX_P35557
    UniProt: P35557

  • Chr Location
    7p13; chr7:44143213-44198170 (-)  GRCh38
Human Diseases
more
  • Diseases
    4 with Gck mouse models; 10 with human GCK associations

Human Disease Mouse Models
      
IDs
 View 1 model
IDs
 View 29 models
IDs
 View 2 models
      
IDs
 View 1 model
      
IDs
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    22 with disease annotations
  • References
    12 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    53 phenotypes from 31 alleles in 25 genetic backgrounds
    7 phenotypes from multigenic genotypes
    66 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Targeted disruption of this gene causes mild hyperglycemia in heterozygous mice and extreme hyperglycemia and embryonic to postnatal lethality in homozygous mice. Hyperglycemic knock-out or ENU-induced mutants may show reduced body weight and liver glycogen level, hepatic steatosis, and glucosuria.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    103
  • GO References
    27
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1042
  • Tissues
    148
  • cDNA Data
    20
  • Literature Summary
    40
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000041798 Ensembl Gene Model | MGI Sequence Detail 49262 C57BL/6J ±  kb
    transcript ENSMUST00000109822 Ensembl | MGI Sequence Detail 1786 Not Applicable  
    polypeptide ENSMUSP00000105447 Ensembl | MGI Sequence Detail 465 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 50
      Genomic 21
      cDNA 21
      Primer pair 7
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2678682, MGI:4357923
    References
    more
    • Summaries
      All 177
      Developmental Gene Expression 40
      Diseases 12
      Gene Ontology 27
      Phenotypes 66
    • Earliest
      J:5824 Coleman DL, Genetic control of glucokinase activity in mice. Biochem Genet. 1977 Apr;15(3-4):297-305
    • Latest
      J:346373 Liu B, et al., NPC1 is required for postnatal islet beta cell differentiation by maintaining mitochondria turnover. Theranostics. 2024;14(5):2058-2074
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/09/2024
    MGI 6.23     		The Jackson Laboratory