Phenotypes Associated with This Genotype

Genotype
MGI:3603003

• Allelic Composition: Gck^tm1.1Mgn/Gck^tm1.1Mgn; Tg(Ins2-cre)25Mgn/0
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, incomplete penetrance ( J:51826 )

• more than 80% neonatal mortality as a result of severe hyperglycemia

homeostasis/metabolism

hyperglycemia ( J:51826 )

• highly variable but increased blood glucose concentrations

decreased circulating insulin level ( J:51826 )

• decreased by about 70%

decreased liver glycogen level ( J:51826 )

• diminished hepatic glycogen

liver/biliary system

decreased liver glycogen level ( J:51826 )

• diminished hepatic glycogen

hepatic steatosis ( J:51826 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
maturity-onset diabetes of the young type 2		DOID:0111100	OMIM:125851	J:51826