Gck^tm1Hrt
Targeted Allele Detail

Summary

• Symbol: Gck^tm1Hrt
• Name: glucokinase; targeted mutation 1, Huan-ran Tan
• MGI ID: MGI:3615946
• Synonyms: gk^lox
• Gene: Gck Location: Chr11:5850820-5900081 bp, - strand Genetic Position: Chr11, 3.88 cM
• Alliance: Gck^tm1Hrt page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:105247
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• LoxP sites were inserted to flank exons 9 and 10 with a third loxP site flanking a neo gene. (J:105247)

Disease models

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gck Mutation: 59 strains or lines available

References

• Original: J:105247 Zhang YL, et al., Establishment of liver specific glucokinase gene knockout mice: a new animal model for screening anti-diabetic drugs. Acta Pharmacol Sin. 2004 Dec;25(12):1659-65
• All: 5 reference(s)