Symbol
Name
ID

Gck
glucokinase
MGI:1270854

Phenotype annotations related to homeostasis/metabolism

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Human Phenotypes

Increased LDL cholesterol concentration

Hypercholesterolemia

Hypertriglyceridemia

Abnormal circulating C-peptide concentration

Reduced C-peptide level

Hyperglycemia

Hypoglycemic seizures

Hypoketotic hypoglycemia

Recurrent hypoglycemia

Glucose intolerance

Diabetes mellitus

Maturity-onset diabetes of the young

Type I diabetes mellitus

Type II diabetes mellitus

Impaired glucose tolerance

Fasting hyperinsulinemia

Hyperinsulinemic hypoglycemia

Insulin resistance

Disease(s) Associated with GCK

coronary artery disease

familial hyperinsulinemic hypoglycemia 3

maturity-onset diabetes of the young type 2

permanent neonatal diabetes mellitus

type 2 diabetes mellitus

Mouse Phenotypes

homeostasis/metabolism phenotype

abnormal insulin secretion

decreased insulin secretion

increased insulin secretion

increased glycosylated hemoglobin level

increased circulating fructosamine level

decreased fasting circulating glucose level

increased fasting circulating glucose level

decreased circulating glucose level

hypoglycemia

increased circulating glucose level

hyperglycemia

abnormal circulating insulin level

decreased circulating insulin level

increased circulating insulin level

abnormal circulating cholesterol level

increased circulating free fatty acids level

increased circulating triglyceride level

increased circulating alkaline phosphatase level

abnormal glucose homeostasis

impaired glucose tolerance

decreased liver glycogen level

decreased glycogen level

increased urine glucose level

insulin resistance

ketosis

decreased glucokinase activity

Availability

Mouse Genotype

Gck^Gena348/Gck^Gena348

Gck^Gls006/Gck^Gls006

Gck^M1Btlr/Gck^M1Btlr

Gck^m1Rge/Gck^m1Rge

Gck^m2Btlr/Gck^m2Btlr

Gck^Rgsc210/Gck^Rgsc210

Gck^Rgsc392/Gck^Rgsc392

Gck^Rgsc702/Gck^Rgsc702

Gck^Sgrd-2Nwu/Gck^Sgrd-2Nwu

Gck^Sgrd/Gck^Sgrd

Gck^tm1.1Mgn/Gck^tm1.1Mgn

Gck^tm1.2Mgn/Gck^tm1.2Mgn

Gck^tm1Mgn/Gck^tm1Mgn

Gck^tm1Tka/Gck^tm1Tka

Gck^tm1Ts/Gck^tm1Ts

Gck^tm2Mgn/Gck^tm2Mgn

Gck^tm3Mgn/Gck^tm3Mgn

Gck^em1(IMPC)H/Gck⁺

Gck^Gena348/Gck⁺

Gck^Gls006/Gck⁺

Gck^M1Btlr/Gck⁺

Gck^m1Rge/Gck⁺

Gck^Rgsc149/Gck⁺

Gck^Rgsc210/Gck⁺

Gck^Rgsc236/Gck⁺

Gck^Rgsc272/Gck⁺

Gck^Rgsc341/Gck⁺

Gck^Rgsc392/Gck⁺

Gck^Rgsc475/Gck⁺

Gck^Rgsc552/Gck⁺

Gck^Rgsc553/Gck⁺

Gck^Rgsc702/Gck⁺

Gck^Rgsc735/Gck⁺

Gck^Rgsc960/Gck⁺

Gck^Sgrd-2Nwu/Gck⁺

Gck^Sgrd/Gck⁺

Gck^Sgrd/Gck^Sgrd-2Nwu

Gck^tm1.2Mgn/Gck⁺

Gck^tm1Efr/Gck⁺

Gck^tm1Tka/Gck⁺

Gck^tm1Ts/Gck⁺

Gck^tm2Mgn/Gck⁺

Gck^tm3Mgn/Gck⁺

Gck^Hlb62/?

Gck^tm1.1Mgn/Gck^tm1.1Mgn
Tg(Ins2-cre)25Mgn/0 (conditional)

Gck^tm1.1Mgn/Gck^tm1.1Mgn
Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ (conditional)

Gck^tm1.1Mgn/Gck⁺
Tg(Ins2-cre)25Mgn/0 (conditional)

Gck^tm1Hrt/Gck⁺
Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ (conditional)

Gck^tm1Ydor/Gck⁺
Tg(Ins2-cre)25Mgn/0 (conditional)

Gck^tm1Ydor/Gck⁺
Tg(Ins1-cre/ERT)1Lphi/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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