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Lmtk2 Gene Detail
Summary
  • Symbol
    Lmtk2
  • Name
    lemur tyrosine kinase 2
  • Synonyms
    2900041G10Rik, A330101P12Rik, AATYK2, BREK, cprk, KPI2, KPI-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:3036247
    NCBI Gene: 231876
  • Gene Overview
    MyGene.info: LMTK2
Location & Maps
more
  • Sequence Map
    Chr5:144100436-144188204 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      87769 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 82.85 cM
  • Mapping Data
    2 experiments
Homology
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  • Human Ortholog
    LMTK2, lemur tyrosine kinase 2
  • Vertebrate Orthologs
    8
  • Human Ortholog
    LMTK2, lemur tyrosine kinase 2
    Orthology source: HomoloGene
  • Synonyms
    AATYK2, BREK, cprk, hBREK, KPI2, KPI-2, LMR2, PPP1R100
  • Links
    NCBI Gene ID: 22853
    neXtProt AC: NX_Q8IWU2

  • Chr Location
    7q21.3; chr7:98106875-98209636 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    8 phenotypes from 1 allele in 1 genetic background
    3 images
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null mutation in this gene display partial prenatal lethality, male infertility, and azoospermia.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000042434 VEGA Gene Model | MGI Sequence Detail 87769 C57BL/6J ±  kb
transcript OTTMUST00000111917 VEGA | MGI Sequence Detail 8114 Not Applicable  
polypeptide OTTMUSP00000062765 VEGA | MGI Sequence Detail 1471 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    234 from dbSNP Build 142
Protein
Information
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  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000009868 serine/threonine-protein kinase LMTK2
  • EC
  • InterPro Domains
    IPR017441 Protein kinase, ATP binding site
    IPR000719 Protein kinase domain
    IPR011009 Protein kinase-like domain
    IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
    IPR008266 Tyrosine-protein kinase, active site
Molecular
Reagents
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  • All nucleic 99
    cDNA 98
    Primer pair 1

    Microarray probesets 2
Other
Accession IDs
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MGI:1920140
References
more
  • Summaries
    All 34
    Developmental Gene Expression 3
    Gene Ontology 4
    Phenotypes 9
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory