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Lmtk2 Gene Detail
Summary
  • Symbol
    Lmtk2
  • Name
    lemur tyrosine kinase 2
  • Synonyms
    2900041G10Rik, A330101P12Rik, AATYK2, BREK, cprk, KPI2, KPI-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:3036247
    NCBI Gene: 231876
  • Gene Overview
    MyGene.info: LMTK2
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr5:144100436-144188204 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      87769 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 82.85 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    LMTK2, lemur tyrosine kinase 2
  • Vertebrate Orthologs
    8
  • Human Ortholog
    LMTK2, lemur tyrosine kinase 2
    Orthology source: HGNC, HomoloGene
  • Synonyms
    AATYK2, BREK, cprk, hBREK, KPI2, KPI-2, LMR2, PPP1R100
  • Links
    NCBI Gene ID: 22853
    neXtProt AC: NX_Q8IWU2
    UniProt: Q8IWU2

  • Chr Location
    7q21.3; chr7:98106868-98209633 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    8 phenotypes from 1 allele in 1 genetic background
    3 images
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null mutation in this gene display partial prenatal lethality, male infertility, and azoospermia.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000042434 VEGA Gene Model | MGI Sequence Detail 87769 C57BL/6J ±  kb
    transcript OTTMUST00000111917 VEGA | MGI Sequence Detail 8114 Not Applicable  
    polypeptide OTTMUSP00000062765 VEGA | MGI Sequence Detail 1471 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      234 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 100
      cDNA 99
      Primer pair 1

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGI:1920140
    References
    more
    • Summaries
      All 39
      Developmental Gene Expression 4
      Gene Ontology 6
      Phenotypes 9
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:215487 Thompson CL, et al., A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain. Neuron. 2014 Jul 16;83(2):309-23

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    09/11/2018
    MGI 6.12
    The Jackson Laboratory