Rgs13
Gene Detail

Symbol Name ID

Rgs13 regulator of G-protein signaling 13 MGI:2180585

Feature Type

protein coding gene

Genetic Map

Chromosome 1

62.56 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr1:144138667-144177372 bp, - strand From VEGA annotation of GRCm38   38706 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:14774  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Protein SuperFamily: regulator of G protein signaling, RGS4 type
Gene Tree: Rgs13

Human homologs

Human Homolog		RGS13, regulator of G-protein signaling 13
NCBI Gene ID		6003
neXtProt AC		NX_O14921
Human Chr (Location)		1q31.2; chr1:192605268-192629441 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(4) : Targeted(4)
 

Mice homozygous for a null allele exhibit increased mast cell degranulation and increased anaphylaxis.

 

Gene Ontology (GO) classifications

All GO classifications: (9 annotations)

Process	G-protein coupled receptor signaling pathway, negative regulation of G-protein coupled receptor protein signaling pathway, ...
Component	cytosol, nucleus, ...
Function	GTPase activator activity, protein binding

External Resources: FuncBase

Expression

Literature Summary: (1 records)
Data Summary: Results (32)    Tissues (25)   
Theiler Stages: 10, 18, 20, 22, 23, 25, 28

Assay Type	Results
Immunohistochemistry	2
RNA in situ	9
Northern blot	20
RT-PCR	1

cDNA source data(8)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(11) Genomic(1) cDNA(8) Primer pair(2)
Microarray probesets(2)

Other database links

VEGA Gene Model	OTTMUSG00000020880 (Evidence)
Ensembl Gene Model	ENSMUSG00000051079 (Evidence)
Entrez Gene	246709 (Evidence)
UniGene	38271
DFCI	TC1591160, TC1637268
DoTS	DT.101347442, DT.99847311
NIA Mouse Gene Index	U021857
Consensus CDS Project	CCDS15348.1
International Mouse Knockout Project Status	Rgs13

Sequences

Length	Strain/Species
genomic	OTTMUSG00000020880	VEGA Gene Model | MGI Sequence Detail	38706	C57BL/6J
transcript	OTTMUST00000049361	VEGA | MGI Sequence Detail	1497	Not Applicable
polypeptide	OTTMUSP00000022853	VEGA | MGI Sequence Detail	158	Not Applicable

All sequences(23) RefSeq(2) UniProt(1)

Polymorphisms

PCR(1) : SNPs(171 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR024066	Regulator of G-protein signaling, domain 1
InterPro	IPR000342	Regulator of G protein signalling
InterPro	IPR016137	Regulator of G protein signalling superfamily
Protein Ontology	PR:000013948	regulator of G-protein signaling 13

References

(Earliest) J:74612 Sierra DA, et al., Evolution of the regulators of G-protein signaling multigene family in mouse and human. Genomics. 2002 Feb;79(2):177-85
(Latest) J:174815 Iwaki S, et al., p53 negatively regulates RGS13 protein expression in immune cells. J Biol Chem. 2011 Jun 24;286(25):22219-26
All references(30)