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Rgs13 Gene Detail
Summary
  • Symbol
    Rgs13
  • Name
    regulator of G-protein signaling 13
  • Feature Type
    protein coding gene
  • IDs
    MGI:2180585
    NCBI Gene: 246709
  • Gene Overview
    MyGene.info: RGS13
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:144138654-144177372 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 62.56 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    260 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2180585
protein coding gene Chr1:144137386-144177372 (-)
129S1/SvImJ MGP_129S1SvImJ_G0016566
protein coding gene Chr1:148493966-148534550 (-)
A/J MGP_AJ_G0016549
protein coding gene Chr1:142572674-142612986 (-)
AKR/J MGP_AKRJ_G0016514
protein coding gene Chr1:146958124-146995753 (-)
BALB/cJ MGP_BALBcJ_G0016509
protein coding gene Chr1:142996713-143036248 (-)
C3H/HeJ MGP_C3HHeJ_G0016334
protein coding gene Chr1:147065850-147104504 (-)
C57BL/6NJ MGP_C57BL6NJ_G0016970
protein coding gene Chr1:153500694-153546093 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014679
protein coding gene Chr1:135365202-135399948 (-)
CAST/EiJ MGP_CASTEiJ_G0015913
protein coding gene Chr1:146487921-146525897 (-)
CBA/J MGP_CBAJ_G0016308
protein coding gene Chr1:158962726-159006691 (-)
DBA/2J MGP_DBA2J_G0016414
protein coding gene Chr1:141670333-141711234 (-)
FVB/NJ MGP_FVBNJ_G0016412
protein coding gene Chr1:140149348-140186069 (-)
LP/J MGP_LPJ_G0016485
protein coding gene Chr1:149507034-149547257 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0016438
protein coding gene Chr1:165389394-165433280 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0017006
protein coding gene Chr1:146683129-146723532 (-)
PWK/PhJ MGP_PWKPhJ_G0015699
protein coding gene Chr1:140576468-140614228 (-)
SPRET/EiJ MGP_SPRETEiJ_G0015486
protein coding gene Chr1:145477154-145517223 (-)
WSB/EiJ MGP_WSBEiJ_G0015976
protein coding gene Chr1:146721756-146761999 (-)



Homology
more
  • Human Ortholog
    RGS13, regulator of G protein signaling 13
  • Vertebrate Orthologs
    8
  • Human Ortholog
    RGS13, regulator of G protein signaling 13
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 6003
    neXtProt AC: NX_O14921
    UniProt: O14921

  • Chr Location
    1q31.2; chr1:192636138-192660311 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    17 phenotypes from 2 alleles in 2 genetic backgrounds
    2 images
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit increased mast cell degranulation and increased anaphylaxis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000051079 Ensembl Gene Model | MGI Sequence Detail 38719 C57BL/6J ±  kb
    transcript ENSMUST00000052375 Ensembl | MGI Sequence Detail 1510 Not Applicable  
    polypeptide ENSMUSP00000058813 Ensembl | MGI Sequence Detail 158 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 12
      Genomic 2
      cDNA 8
      Primer pair 2

      Microarray probesets 2
    References
    more
    • Summaries
      All 27
      Developmental Gene Expression 1
      Gene Ontology 3
      Phenotypes 7
    • Earliest
      J:74612 Sierra DA, et al., Evolution of the regulators of G-protein signaling multigene family in mouse and human. Genomics. 2002 Feb;79(2):177-85
    • Latest
      J:199530 Hwang IY, et al., Rgs13 constrains early B cell responses and limits germinal center sizes. PLoS One. 2013;8(3):e60139

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory