Rgs13 MGI Mouse Gene Detail - MGI:2180585 - regulator of G-protein signaling 13

Symbol

Rgs13
Name

regulator of G-protein signaling 13

Feature Type

protein coding gene
IDs

MGI:2180585
NCBI Gene: 246709
Alliance

genome feature page
Transcription Start Sites

2 TSS

Sequence Map

Chr1:144014392-144053110 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 62.56 cM
Mapping Data

2 experiments

SNPs within 2kb

1165 from dbSNP Build 142
Strain Annotations

19
PCR

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2180585	protein coding gene	Chr1:144013083-144053240 (-)
129S1/SvImJ	ENSMUSG00200007760	protein coding gene	Chr1:141488752-141527475 (-)
A/J	ENSMUSG00195015550	protein coding gene	Chr1:140820427-140858288 (-)
AKR/J	ENSMUSG00220002680	protein coding gene	Chr1:140562990-140599719 (-)
BALB/cJ	ENSMUSG00180011316	protein coding gene	Chr1:141018784-141057496 (-)
C3H/HeJ	ENSMUSG00175006443	protein coding gene	Chr1:141037576-141075442 (-)
C57BL/6NJ	ENSMUSG00215014696	protein coding gene	Chr1:140948146-140986865 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014679	protein coding gene	Chr1:135365202-135399948 (-)
CAST/EiJ	ENSTCUG00005013155	protein coding gene	Chr1:139762287-139799858 (-)
CBA/J	ENSMUSG00210014247	protein coding gene	Chr1:140958277-140996130 (-)
DBA/2J	ENSMUSG00185006790	protein coding gene	Chr1:145267369-145306094 (-)
FVB/NJ	ENSMUSG00205002193	protein coding gene	Chr1:140173873-140211732 (-)
JF1/MsJ	ENSUMUG00000011389	protein coding gene	Chr1:144567885-144610101 (-)
LP/J	ENSMUSG00230000379	protein coding gene	Chr1:144780824-144819548 (-)
NOD/ShiLtJ	ENSMUSG00190002813	protein coding gene	Chr1:140784283-140823664 (-)
NZO/HlLtJ	ENSMUSG00225000062	protein coding gene	Chr1:148547390-148586112 (-)
PWK/PhJ	ENSLUMG00010001772	protein coding gene	Chr1:139885026-139921859 (-)
SPRET/EiJ	ENSMSPG00010011637	protein coding gene	Chr1:142798609-142853667 (-)
WSB/EiJ	ENSIUOG00005025620	protein coding gene	Chr1:140334914-140373643 (-)

Human Ortholog

RGS13, regulator of G protein signaling 13

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

RGS13, regulator of G protein signaling 13
Links

HGNC:9995

NCBI Gene ID: 6003

UniProt: O14921
Chr Location

1q31.2; chr1:192636061-192660311 (+) GRCh38

MGI Vertebrate Homology

Rgs13 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: RGS13
Gene Tree

Rgs13

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Phenotype Summary

17 phenotypes from 2 alleles in 2 genetic backgrounds
2 images
9 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

9
Chemically induced (other)

2
Endonuclease-mediated

2
Targeted

5
Genomic Mutations

2 involving Rgs13
Incidental Mutations

APF
Find Mice (IMSR)

14 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele exhibit increased mast cell degranulation and increased anaphylaxis.

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All GO Annotations

10
GO References

3

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

629
Tissues

25
cDNA Data

8
Literature Summary

1

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

ZFIN rgs13a

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All Sequences

34
RefSeq

4
UniProt

1
CCDS

CCDS15348.1

Ensembl

ENSMUSG00000051079 (Evidence)
NCBI Gene

246709

			Length	Strain/Species	Flank
genomic	ENSMUSG00000051079	Ensembl Gene Model \| MGI Sequence Detail	38719	C57BL/6J	± kb
transcript	ENSMUST00000052375	Ensembl \| MGI Sequence Detail	1510	Not Applicable
polypeptide	ENSMUSP00000058813	Ensembl \| MGI Sequence Detail	158	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000013948 regulator of G-protein signaling 13

(term hierarchy)
InterPro Domains

IPR016137 RGS domain

IPR036305 RGS domain superfamily

IPR024066 RGS, subdomain 1/3

IPR044926 RGS, subdomain 2

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All nucleic 12

Genomic 2

cDNA 8

Primer pair 2

Antibodies 1

Microarray probesets 2

Summaries

All 30

Developmental Gene Expression 1

Gene Ontology 3

Phenotypes 9
Earliest

J:74612 Sierra DA, et al., Evolution of the regulators of G-protein signaling multigene family in mouse and human. Genomics. 2002 Feb;79(2):177-85
Latest

J:199530 Hwang IY, et al., Rgs13 constrains early B cell responses and limits germinal center sizes. PLoS One. 2013;8(3):e60139

TSS for Rgs13:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr14104	Chr1:144052997-144053019 (-)	102 bp
Tssr14103	Chr1:144052923-144052934 (-)	181 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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