About   Help   FAQ
Rgs13
Gene Detail
 Symbol
Name
ID
Rgs13
regulator of G-protein signaling 13
MGI:2180585
Feature Type protein coding gene
Genetic Map
Chromosome 1
62.56 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr1:144138654-144177372 bp, - strand
From VEGA annotation of GRCm38

  38719 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:14774  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 western clawed frog

Protein SuperFamily: regulator of G protein signaling, RGS4 type
Gene Tree: Rgs13

Human
homologs
Human Homolog RGS13, regulator of G-protein signaling 13
NCBI Gene ID 6003
neXtProt AC  NX_O14921
Human Chr (Location)  1q31.2; chr1:192636138-192660311 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(5)
Incidental mutations (data from APF )
 
Mice homozygous for a null allele exhibit increased mast cell degranulation and increased anaphylaxis.
 
Interactions
Rgs13 interacts with 137 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (11 annotations)
Process G-protein coupled receptor signaling pathway, negative regulation of G-protein coupled receptor protein signaling pathway, ...
Component cytosol, nucleus, ...
Function GTPase activator activity, protein binding
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (32)    Tissues (25)   
Theiler Stages: 10, 18, 20, 22, 23, 25, 27, 28
Assay TypeResults
Immunohistochemistry 2
RNA in situ 9
Northern blot 20
RT-PCR 1
cDNA source data(8)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(11) Genomic(1) cDNA(8) Primer pair(2)
Microarray probesets(2)
Other database
links
VEGA Gene ModelOTTMUSG00000020880 (Evidence)
Ensembl Gene ModelENSMUSG00000051079 (Evidence)
Entrez Gene246709 (Evidence)
UniGene38271
DFCITC1591160, TC1637268
DoTSDT.101347442, DT.99847311
NIA Mouse Gene IndexU021857
Consensus CDS ProjectCCDS15348.1
International Mouse Knockout Project StatusRgs13
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000020880 VEGA Gene Model | MGI Sequence Detail 38719 C57BL/6J ±  kb
transcript OTTMUST00000049361 VEGA | MGI Sequence Detail 1510 Not Applicable 
polypeptide OTTMUSP00000022853 VEGA | MGI Sequence Detail 158 Not Applicable 

For the selected sequences
All sequences(25) RefSeq(4) UniProt(1)
Polymorphisms PCR(1) : SNPs within 2kb(262 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR024066 Regulator of G-protein signaling, domain 1
InterPro IPR000342 Regulator of G protein signalling
InterPro IPR016137 Regulator of G protein signalling superfamily
Protein Ontology PR:000013948 regulator of G-protein signaling 13
References (Earliest) J:74612 Sierra DA, et al., Evolution of the regulators of G-protein signaling multigene family in mouse and human. Genomics. 2002 Feb;79(2):177-85
(Latest) J:199530 Hwang IY, et al., Rgs13 constrains early B cell responses and limits germinal center sizes. PLoS One. 2013;8(3):e60139
All references(31)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/26/2014
MGI 5.19
The Jackson Laboratory