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Tlr7 Gene Detail
Summary
  • Symbol
    Tlr7
  • Name
    toll-like receptor 7
  • Feature Type
    protein coding gene
  • IDs
    MGI:2176882
    NCBI Gene: 170743
  • Gene Overview
    MyGene.info: TLR7
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:167304929-167330558 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome X, 78.31 cM, cytoband F5
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    111 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2176882
protein coding gene ChrX:167304926-167330574 (-)
129S1/SvImJ MGP_129S1SvImJ_G0036271
protein coding gene ChrX:165479182-165506400 (-)
A/J MGP_AJ_G0036240
protein coding gene ChrX:164614447-164639968 (-)
AKR/J MGP_AKRJ_G0036170
protein coding gene ChrX:169895909-169921443 (-)
BALB/cJ MGP_BALBcJ_G0036235
protein coding gene ChrX:162566747-162592346 (-)
C3H/HeJ MGP_C3HHeJ_G0035942
protein coding gene ChrX:165783551-165809443 (-)
C57BL/6NJ MGP_C57BL6NJ_G0036758
protein coding gene ChrX:170275876-170303028 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0033578
protein coding gene ChrX:155417353-155442112 (-)
CAST/EiJ MGP_CASTEiJ_G0035229
protein coding gene ChrX:144660950-144687256 (-)
CBA/J MGP_CBAJ_G0035916
protein coding gene ChrX:175239566-175266634 (-)
DBA/2J MGP_DBA2J_G0036082
protein coding gene ChrX:163422122-163447814 (-)
FVB/NJ MGP_FVBNJ_G0036014
protein coding gene ChrX:162560779-162586306 (-)
LP/J MGP_LPJ_G0036167
protein coding gene ChrX:166541554-166567146 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0036046
protein coding gene ChrX:183925689-183952576 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0036797
protein coding gene ChrX:164926187-164952745 (-)
PWK/PhJ MGP_PWKPhJ_G0034928
protein coding gene ChrX:141385053-141411354 (-)
SPRET/EiJ MGP_SPRETEiJ_G0034747
protein coding gene ChrX:145192887-145217739 (-)
WSB/EiJ MGP_WSBEiJ_G0035365
protein coding gene ChrX:162772178-162799917 (-)



Homology
more
  • Human Ortholog
    TLR7, toll like receptor 7
  • Vertebrate Orthologs
    10
  • Human Ortholog
    TLR7, toll like receptor 7
    Orthology source: HomoloGene, HGNC
  • Synonyms
    TLR7-like
  • Links
    NCBI Gene ID: 51284
    neXtProt AC: NX_Q9NYK1
    UniProt: Q9NYK1

  • Chr Location
    Xp22.2; chrX:12867083-12890361 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Tlr7 mouse models

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    36 phenotypes from 7 alleles in 8 genetic backgrounds
    32 phenotypes from multigenic genotypes
    191 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
The innate immune response to viral infection is affected in homozygous null mice. Mice homozygous or hemizygous for a point mutation produce little or no tumor necrosis factor (TNF) alpha in response to stimulation by a single stranded RNA analog.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000044583 Ensembl Gene Model | MGI Sequence Detail 25630 C57BL/6J ±  kb
    transcript ENSMUST00000112161 Ensembl | MGI Sequence Detail 3897 Not Applicable  
    polypeptide ENSMUSP00000107787 Ensembl | MGI Sequence Detail 1050 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 12
      cDNA 11
      Primer pair 1

      Microarray probesets 4
    References
    more
    • Summaries
      All 324
      Developmental Gene Expression 3
      Diseases 2
      Gene Ontology 16
      Phenotypes 191
    • Earliest
      J:90979 Hemmi H, et al., Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway. Nat Immunol. 2002 Feb;3(2):196-200
    • Latest
      J:265925 Le Gallou S, et al., A splenic IgM memory subset with antibacterial specificities is sustained from persistent mucosal responses. J Exp Med. 2018 Aug 6;215(8):2035-2053

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/13/2018
    MGI 6.13
    The Jackson Laboratory