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Tlr7 Gene Detail
Summary
  • Symbol
    Tlr7
  • Name
    toll-like receptor 7
  • Feature Type
    protein coding gene
  • IDs
    MGI:2176882
    NCBI Gene: 170743
  • Alliance
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:166087925-166113554 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome X, 78.31 cM, cytoband F5
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    111 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2176882
protein coding gene ChrX:166086376-166113570 (-)
129S1/SvImJ MGP_129S1SvImJ_G0036271
protein coding gene ChrX:165479182-165506400 (-)
A/J MGP_AJ_G0036240
protein coding gene ChrX:164614447-164639968 (-)
AKR/J MGP_AKRJ_G0036170
protein coding gene ChrX:169895909-169921443 (-)
BALB/cJ MGP_BALBcJ_G0036235
protein coding gene ChrX:162566747-162592346 (-)
C3H/HeJ MGP_C3HHeJ_G0035942
protein coding gene ChrX:165783551-165809443 (-)
C57BL/6NJ MGP_C57BL6NJ_G0036758
protein coding gene ChrX:170275876-170303028 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0033578
protein coding gene ChrX:155417353-155442112 (-)
CAST/EiJ MGP_CASTEiJ_G0035229
protein coding gene ChrX:144660950-144687256 (-)
CBA/J MGP_CBAJ_G0035916
protein coding gene ChrX:175239566-175266634 (-)
DBA/2J MGP_DBA2J_G0036082
protein coding gene ChrX:163422122-163447814 (-)
FVB/NJ MGP_FVBNJ_G0036014
protein coding gene ChrX:162560779-162586306 (-)
LP/J MGP_LPJ_G0036167
protein coding gene ChrX:166541554-166567146 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0036046
protein coding gene ChrX:183925689-183952576 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0036797
protein coding gene ChrX:164926187-164952745 (-)
PWK/PhJ MGP_PWKPhJ_G0034928
protein coding gene ChrX:141385053-141411354 (-)
SPRET/EiJ MGP_SPRETEiJ_G0034747
protein coding gene ChrX:145192887-145217739 (-)
WSB/EiJ MGP_WSBEiJ_G0035365
protein coding gene ChrX:162772178-162799917 (-)



Homology
more
  • Human Ortholog
    TLR7, toll like receptor 7
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TLR7, toll like receptor 7
  • Synonyms
    IMD74, SLEB17, TLR7-like
  • Links
    NCBI Gene ID: 51284
    neXtProt AC: NX_Q9NYK1
    UniProt: Q9NYK1

  • Chr Location
    Xp22.2; chrX:12867072-12890361 (+)  GRCh38

Human Diseases
more
  • Diseases
    1 with Tlr7 mouse models; 2 with human TLR7 associations

Human Disease Mouse Models
      
IDs
View 4 models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    3 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    56 phenotypes from 6 alleles in 9 genetic backgrounds
    55 phenotypes from multigenic genotypes
    313 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
The innate immune response to viral infection is affected in homozygous null mice. Mice homozygous or hemizygous for a point mutation produce little or no tumor necrosis factor (TNF) alpha in response to stimulation by a single stranded RNA analog.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000044583 Ensembl Gene Model | MGI Sequence Detail 25630 C57BL/6J ±  kb
    transcript ENSMUST00000112164 Ensembl | MGI Sequence Detail 3468 Not Applicable  
    polypeptide ENSMUSP00000107789 Ensembl | MGI Sequence Detail 1050 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 14
      cDNA 11
      Primer pair 2
      Other 1

      Microarray probesets 4
    References
    more
    • Summaries
      All 469
      Developmental Gene Expression 10
      Diseases 3
      Gene Ontology 15
      Phenotypes 313
    • Earliest
      J:90979 Hemmi H, et al., Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway. Nat Immunol. 2002 Feb;3(2):196-200
    • Latest
      J:342540 Cosgrove HA, et al., B cell-intrinsic TLR7 expression drives severe lupus in TLR9-deficient mice. JCI Insight. 2023 Aug 22;8(16)

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    03/12/2024
    MGI 6.23
    The Jackson Laboratory