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Tlr7 Gene Detail
Summary
  • Symbol
    Tlr7
  • Name
    toll-like receptor 7
  • Feature Type
    protein coding gene
  • IDs
    MGI:2176882
    NCBI Gene: 170743
  • Gene Overview
    MyGene.info: TLR7
  • Alliance
Location & Maps
more
  • Sequence Map
    ChrX:167304929-167330558 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      25630 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome X, 78.31 cM, cytoband F5
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    TLR7, toll like receptor 7
  • Vertebrate Orthologs
    10
  • Human Ortholog
    TLR7, toll like receptor 7
    Orthology source: HomoloGene, HGNC
  • Synonyms
    TLR7-like
  • Links
    NCBI Gene ID: 51284
    neXtProt AC: NX_Q9NYK1
    UniProt: Q9NYK1

  • Chr Location
    Xp22.2; chrX:12867083-12890361 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Tlr7 mouse models

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    36 phenotypes from 7 alleles in 8 genetic backgrounds
    32 phenotypes from multigenic genotypes
    183 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
The innate immune response to viral infection is affected in homozygous null mice. Mice homozygous or hemizygous for a point mutation produce little or no tumor necrosis factor (TNF) alpha in response to stimulation by a single stranded RNA analog.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000019578 VEGA Gene Model | MGI Sequence Detail 25630 C57BL/6J ±  kb
    transcript OTTMUST00000046751 VEGA | MGI Sequence Detail 3897 Not Applicable  
    polypeptide OTTMUSP00000021130 VEGA | MGI Sequence Detail 1050 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      111 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 12
      cDNA 11
      Primer pair 1

      Microarray probesets 4
    References
    more
    • Summaries
      All 315
      Developmental Gene Expression 3
      Diseases 2
      Gene Ontology 14
      Phenotypes 183
    • Earliest
      J:90979 Hemmi H, et al., Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway. Nat Immunol. 2002 Feb;3(2):196-200
    • Latest
      J:260537 Linehan MM, et al., A minimal RNA ligand for potent RIG-I activation in living mice. Sci Adv. 2018 Feb;4(2):e1701854

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    07/10/2018
    MGI 6.12
    The Jackson Laboratory