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Tlr7
Gene Detail
Symbol

Name
ID
Tlr7
toll-like receptor 7
MGI:2176882
Feature Type
protein coding gene
Genetic Map
Chromosome X
78.31 cM, cytoband F5
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
ChrX:167304929-167330558 bp, - strand
From VEGA annotation of GRCm38

  25630 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:75060  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: TLR7
Protein SuperFamily: toll-like receptor, 7/8/9 types
Gene Tree: Tlr7

Human
homologs
TLR7, toll-like receptor 7
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 51284
neXtProt AC: NX_Q9NYK1

Human Synonyms: TLR7-like

Human Chr (Location): Xp22.3; chrX:12867083-12890361 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Chemically induced (ENU)(2) Targeted(4) Transgenic(1)
Incidental mutations (data from APF )
 
The innate immune response to viral infection is affected in homozygous null mice. Mice homozygous or hemizygous for a point mutation produce little or no tumor necrosis factor (TNF) alpha in response to stimulation by a single stranded RNA analog.
 
Human Diseases Modeled in Mice Using Tlr7 (1)    Mutations Annotated to Human Diseases (1)   
Interactions
Tlr7 interacts with 93 markers (Mir10a, Mir10b, Mir19a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (39 annotations)
Process defense response to virus, I-kappaB phosphorylation, ...
Component cytoplasm, cytoplasmic vesicle, ...
Function double-stranded RNA binding, drug binding, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (28)    Tissues (17)    Images (2)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 24
RT-PCR 4
cDNA source data(10)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase tlr7 ; ZFIN tlr7    NEW 
Molecular
reagents
All nucleic(11) cDNA(10) Primer pair(1)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000019578 (Evidence)
Ensembl Gene Model ENSMUSG00000044583 (Evidence)
Entrez Gene 170743 (Evidence)
DFCI TC1581762, TC1731398, TC1739688, TC1766917
DoTS DT.101221159, DT.101234253, DT.40165320, DT.485974, DT.97383950, DT.99857703
Consensus CDS Project CCDS30531.1, CCDS72469.1
International Mouse Phenotyping Consortium Status Tlr7
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000019578 VEGA Gene Model | MGI Sequence Detail 25630 C57BL/6J ±  kb
transcript OTTMUST00000046751 VEGA | MGI Sequence Detail 3897 Not Applicable 
polypeptide OTTMUSP00000021130 VEGA | MGI Sequence Detail 1050 Not Applicable 

For the selected sequences
All sequences(71) RefSeq(16) UniProt(6)
Polymorphisms
SNPs within 2kb(111 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000483 Cysteine-rich flanking region, C-terminal
InterPro IPR001611 Leucine-rich repeat
InterPro IPR000372 Leucine-rich repeat N-terminal domain
InterPro IPR003591 Leucine-rich repeat, typical subtype
InterPro IPR000157 Toll/interleukin-1 receptor homology (TIR) domain
InterPro IPR026880 Toll-like receptor 7
Protein Ontology PR:000001158 Toll-like receptor 7
References
(Earliest) J:90979 Hemmi H, et al., Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway. Nat Immunol. 2002 Feb;3(2):196-200
(Latest) J:221896 Matsuda T, et al., TLR9 signalling in microglia attenuates seizure-induced aberrant neurogenesis in the adult hippocampus. Nat Commun. 2015;6:6514
All references(226)
Disease annotation references (1)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory