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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Tlr7
toll-like receptor 7
MGI:2176882
40 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
Faslpr/Faslpr
Tlr7tm1Flv/Y
involves: 129S1/Sv * C57BL/6 * MRL/Mp 		abnormal B cell activation J:113557
abnormal CD4-positive, alpha beta T cell morphology J:113557
abnormal lymph node size J:113557
abnormal plasmacytoid dendritic cell physiology J:113557
decreased autoantibody level J:113557
decreased double-negative T cell number J:113557
decreased IgG2a level J:113557
decreased IgG3 level J:113557
decreased spleen weight J:113557
decreased susceptibility to systemic lupus erythematosus J:113557
increased anti-chromatin antibody level J:113557
increased autoantibody level J:113557
Fcgr2btm1Ttk/Fcgr2btm1Ttk
Tlr7tm1Flv/Y
X/Yaa
B6.Cg-Fcgr2btm1Ttk Tlr7tm1Flv Yaa 		abnormal kidney morphology J:127600
abnormal splenocyte physiology J:127600
autoimmune response J:127600
enlarged spleen J:127600
increased anti-nuclear antigen antibody level J:127600
increased susceptibility to systemic lupus erythematosus J:127600
premature death J:127600
Nba10NZB/Nba10NZB
Tlr7tm1Aki/Y
X/Yaa
B6.Cg-Nba10NZB Tlr7tm1Aki Yaa 		abnormal immune serum protein physiology J:137656
glomerulonephritis J:137656
increased anti-chromatin antibody level J:137656
increased monocyte cell number J:137656
Rnaseh2bem1Anu/Rnaseh2b+
Tlr7em2Anu/Tlr7+
C57BL/6NCrl-Rnaseh2bem1Anu Tlr7em2Anu 		abnormal immune system morphology J:324448
abnormal mature B cell morphology J:324448
increased autoantibody level J:324448
increased CD4-positive, alpha-beta T cell number J:324448
increased germinal center B cell number J:324448
increased plasma cell number J:324448
increased T follicular helper cell number J:324448
Smcr8em1Btlr/Smcr8em1Btlr
Tlr3tm1Flv/Tlr3tm1Flv
Tlr7tm1Aki/Tlr7tm1Aki
Tlr9tm1Aki/Tlr9tm1Aki
involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6J 		normal immune system phenotype J:268243
Tlr3tm1Aki/Tlr3tm1Aki
Tlr7tm1Aki/Tlr7tm1Aki
involves: 129P2/OlaHsd 		decreased interferon-alpha secretion J:144400
Tlr7tm1Aki/Tlr7tm1Aki
Unc93b1tm1.1Kmiy/Unc93b1tm1.1Kmiy
involves: 129P2/OlaHsd * C57BL/6 		normal hematopoietic system phenotype J:174308
normal mortality/aging J:174308
Tlr7tm1Flv/Y
X/Yaa
B6.Cg-Tlr7tm1Flv Yaa 		normal hematopoietic system phenotype J:127600
Tlr8/Tlr7tm1Vlcg/Tlr7+
Tlr8/Tlr7tm1Vlcg/Tlr8tm1Vlcg
B6.Cg-Tlr8/Tlr7tm1Vlcg Tlr8tm1Vlcg 		abnormal spleen marginal zone morphology J:165267
decreased anti-insulin autoantibody level J:165267
decreased IgG level J:165267
decreased IgM level J:165267
decreased marginal zone B cell number J:165267
increased IgG level J:165267
increased IgM level J:165267
increased marginal zone B cell number J:165267
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory