Tlr7^em2Anu
Endonuclease-mediated Allele Detail

Summary

• Symbol: Tlr7^em2Anu
• Name: toll-like receptor 7; endonuclease-mediated mutation 2, Australian National University
• MGI ID: MGI:7279260
• Synonyms: kika, Tlr7^{em2(Y264H)Anu}, TLR7^kik, TLR7^Y264H
• Gene: Tlr7 Location: ChrX:166087925-166113554 bp, - strand Genetic Position: ChrX, 78.31 cM, cytoband F5
• Alliance: Tlr7^em2Anu page

Mutation origin

• Strain of Origin: C57BL/6NCrl

Mutation description

• Allele Type: Endonuclease-mediated (Not Specified)
• Mutation: Single point mutation
• Mutation details: CRISPR-targeting introduced the mutation that produces the amino acid substitution tyrosine to histidine at position 264 (Y264H). (J:324448)

Disease models

Expression

In Structures Affected by this Mutation:

13 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tlr7 Mutation: 21 strains or lines available

References

• Original: J:324448 Brown GJ, et al., TLR7 gain-of-function genetic variation causes human lupus. Nature. 2022;605(7909):349-356
• All: 1 reference(s)