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Targeted Allele Detail
Symbol: Tlr7tm1Aki
Name: toll-like receptor 7; targeted mutation 1, Shizuo Akira
MGI ID: MGI:3045662
Synonyms: Tlr7-
Gene: Tlr7  Location: ChrX:166087925-166113554 bp, - strand  Genetic Position: ChrX, 78.31 cM, cytoband F5
Alliance: Tlr7tm1Aki page
Germline Transmission:  Earliest citation of germline transmission: J:90979
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA neo replaced 1.8 kb of sequence that encodes a part of a leucine-rich repeat by homologous recombination. Recombination was confirmed by Southern analysis of tails from mutant males. (J:90979)
View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 2 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 3 strains available      Cell Lines: 0 lines available
Carrying any Tlr7 Mutation:  21 strains or lines available
Original:  J:90979 Hemmi H, et al., Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway. Nat Immunol. 2002 Feb;3(2):196-200
All:  170 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.23
The Jackson Laboratory