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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Tlr7
toll-like receptor 7
MGI:2176882
68 phenotypes from 8 alleles in 10 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Tg(Tlr7)1Boll/0
involves: C57BL/6 		abnormal circulating chemokine level J:127600
abnormal dendritic cell morphology J:127600
abnormal spleen morphology J:127600
anemia J:127600
autoimmune response J:127600
decreased spleen white pulp amount J:127600
enlarged spleen J:127600
extramedullary hematopoiesis J:127600
glomerulonephritis J:127600
increased anti-nuclear antigen antibody level J:127600
increased circulating interleukin-6 level J:127600
increased circulating tumor necrosis factor level J:127600
liver inflammation J:127600
premature death J:127600
thrombocytopenia J:127600
X/Tg(Tlr7)6Boll
involves: C57BL/6 		abnormal B cell activation J:127600
abnormal B cell morphology J:127600
abnormal dendritic cell morphology J:127600
abnormal T cell activation J:127600
autoimmune response J:127600
decreased marginal zone B cell number J:127600
enlarged spleen J:127600
glomerulonephritis J:127600
increased anti-nuclear antigen antibody level J:127600
increased mature B cell number J:127600
increased splenocyte proliferation J:127600
liver inflammation J:127600
lung inflammation J:127600
premature death J:127600
Tlr7em2Anu/Tlr7+
C57BL/6NCrl-Tlr7em2Anu 		abnormal mature B cell morphology J:324448
abnormal plasmacytoid dendritic cell physiology J:324448
decreased marginal zone B cell number J:324448
enlarged spleen J:324448
expanded mesangial matrix J:324448
increased anti-double stranded DNA antibody level J:324448
increased anti-nuclear antigen antibody level J:324448
increased anti-single stranded DNA antibody level J:324448
increased autoantibody level J:324448
increased B cell number J:324448
increased CD4-positive, alpha-beta T cell number J:324448
increased circulating interferon-gamma level J:324448
increased circulating interleukin-6 level J:324448
increased circulating interleukin-10 level J:324448
increased circulating tumor necrosis factor level J:324448
increased germinal center B cell number J:324448
increased plasma cell number J:324448
increased spleen germinal center number J:324448
increased T follicular helper cell number J:324448
premature death J:324448
renal glomerular immunoglobulin deposits J:324448
spleen hyperplasia J:324448
thrombocytopenia J:324448
Tlr7em2Anu/Y
C57BL/6NCrl-Tlr7em2Anu 		abnormal B cell physiology J:324448
abnormal macrophage physiology J:324448
abnormal muscle morphology J:324448
abnormal Peyer's patch morphology J:324448
cardiac fibrosis J:324448
decreased B cell apoptosis J:324448
decreased B cell proliferation J:324448
enlarged spleen J:324448
increased anti-double stranded DNA antibody level J:324448
increased anti-nuclear antigen antibody level J:324448
increased anti-single stranded DNA antibody level J:324448
increased autoantibody level J:324448
increased CD4-positive, alpha-beta T cell number J:324448
increased circulating interferon-gamma level J:324448
increased circulating interleukin-6 level J:324448
increased circulating interleukin-10 level J:324448
increased circulating tumor necrosis factor level J:324448
increased effector memory CD4-positive, alpha-beta T cell number J:324448
increased splenic marginal zone lymphoma incidence J:324448
increased susceptibility to systemic lupus erythematosus J:324448
increased T follicular helper cell number J:324448
liver inflammation J:324448
lung inflammation J:324448
lymph node inflammation J:324448
premature death J:324448
Tlr7em2Anu/Tlr7em2Anu
C57BL/6NCrl-Tlr7em2Anu 		abnormal exocrine pancreas morphology J:324448
abnormal mature B cell morphology J:324448
abnormal muscle morphology J:324448
abnormal Peyer's patch morphology J:324448
abnormal plasmacytoid dendritic cell physiology J:324448
cardiac fibrosis J:324448
decreased leukocyte cell number J:324448
decreased marginal zone B cell number J:324448
enlarged spleen J:324448
glomerulonephritis J:324448
increased anti-nuclear antigen antibody level J:324448
increased anti-single stranded DNA antibody level J:324448
increased B cell number J:324448
increased CD4-positive, alpha-beta T cell number J:324448
increased effector memory CD4-positive, alpha-beta T cell number J:324448
increased germinal center B cell number J:324448
increased inflammatory response J:324448
increased plasma cell number J:324448
increased spleen germinal center number J:324448
increased splenic marginal zone lymphoma incidence J:324448
increased susceptibility to systemic lupus erythematosus J:324448
increased T follicular helper cell number J:324448
liver inflammation J:324448
lung inflammation J:324448
lymph node inflammation J:324448
pancreas inflammation J:324448
premature death J:324448
salivary gland inflammation J:324448
spleen hyperplasia J:324448
Tlr7rsq1/Y
C57BL/6J-Tlr7rsq1 		abnormal macrophage physiology J:128404
decreased tumor necrosis factor secretion J:128404
Tlr7rsq1/Tlr7rsq1
C57BL/6J-Tlr7rsq1 		abnormal macrophage physiology J:128404
decreased tumor necrosis factor secretion J:128404
Tlr7rsq2/Y
C57BL/6J-Tlr7rsq2 		abnormal macrophage physiology J:140020
decreased tumor necrosis factor secretion J:140020
Tlr7tm1Aki/Tlr7tm1Aki
B6.129P2-Tlr7tm1Aki 		abnormal dendritic cell physiology J:118954
decreased interleukin-12b secretion J:118954
Tlr7tm1Aki/Tlr7tm1Aki
involves: 129P2/OlaHsd 		decreased interferon-alpha secretion J:144400
Tlr7tm1Aki/Tlr7tm1Aki
involves: 129P2/OlaHsd * C57BL/6 		normal hematopoietic system phenotype J:137066
Tlr7tm1Flv/Y
B6.129S1-Tlr7tm1Flv 		decreased splenocyte proliferation J:127600
increased marginal zone B cell number J:127600
Tlr7tm1Flv/Tlr7tm1Flv
B6.129S1-Tlr7tm1Flv 		decreased anti-insulin autoantibody level J:165267
decreased IgG1 level J:165267
decreased IgG2a level J:165267
decreased IgG level J:165267
decreased IgM level J:165267
Tlr7tm1Flv/Tlr7tm1Flv
involves: 129S1/Sv 		decreased circulating interferon-alpha level J:89257
Tlr8/Tlr7tm1Vlcg/Tlr8/Tlr7tm1Vlcg
B6.Cg-Tlr8/Tlr7tm1Vlcg Tlr8tm1Vlcg 		decreased anti-insulin autoantibody level J:165267
decreased follicular B cell number J:165267
increased marginal zone B cell number J:165267
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory