Automated description from the Alliance of Genome Resources (Release 7.0.0)
Enables siRNA binding activity and single-stranded RNA binding activity. Involved in several processes, including positive regulation of macromolecule biosynthetic process; response to virus; and toll-like receptor 7 signaling pathway. Acts upstream of or within positive regulation of interleukin-6 production; positive regulation of macrophage cytokine production; and regulation of protein phosphorylation. Located in cytoplasmic vesicle; endoplasmic reticulum; and lysosome. Is expressed in brain and liver. Used to study systemic lupus erythematosus. Human ortholog(s) of this gene implicated in COVID-19 and X-Linked immunodeficiency 74. Orthologous to human TLR7 (toll like receptor 7).