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Nfkbiz Gene Detail
Summary
  • Symbol
    Nfkbiz
  • Name
    nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, zeta
  • Synonyms
    Mail
  • Feature Type
    protein coding gene
  • IDs
    MGI:1931595
    NCBI Gene: 80859
  • Gene Overview
    MyGene.info: NFKBIZ
  • Alliance
  • Transcription Start Sites
    14 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:55811377-55838641 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 16, 33.65 cM, cytoband C1.2 - C1.3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    440 from dbSNP Build 142
  • Strain Annotations
    3
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1931595
protein coding gene Chr16:55811375-55838899 (-)
129S1/SvImJ no annotation
A/J no annotation
AKR/J no annotation
BALB/cJ no annotation
C3H/HeJ no annotation
C57BL/6NJ no annotation
CAROLI/EiJ MGP_CAROLIEiJ_G0020807
protein coding gene Chr16:52272075-52298668 (-)
CAST/EiJ no annotation
CBA/J no annotation
DBA/2J no annotation
FVB/NJ no annotation
LP/J no annotation
NOD/ShiLtJ no annotation
NZO/HlLtJ no annotation
PWK/PhJ MGP_PWKPhJ_G0021876
protein coding gene Chr16:52634259-52662919 (-)
SPRET/EiJ no annotation
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    NFKBIZ, NFKB inhibitor zeta
  • Vertebrate Orthologs
    10
  • Human Ortholog
    NFKBIZ, NFKB inhibitor zeta
    Orthology source: HomoloGene, HGNC
  • Synonyms
    IKBZ, INAP, MAIL
  • Links
    NCBI Gene ID: 64332
    neXtProt AC: NX_Q9BYH8
    UniProt: Q9BYH8

  • Chr Location
    3q12.3; chr3:101827990-101861025 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    2 with Nfkbiz mouse models

Human Disease Mouse Models
      
IDs
View 1 model
IDs
View 2 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    47 phenotypes from 3 alleles in 7 genetic backgrounds
    12 phenotypes from multigenic genotypes
    2 images
    23 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous inactivation of this gene may lead to background sensitive prenatal lethality and results in abnormal cytokine secretion, higher IgE levels, ocular surface and perioral skin inflammation accompanied by hair loss, and severe atopic dermatitis-like skin lesions.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 80859 NCBI Gene Model | MGI Sequence Detail 27265 C57BL/6J ±  kb
    transcript NM_030612 RefSeq | MGI Sequence Detail 3855 C57BL/6  
    polypeptide Q9EST8 UniProt | EBI | MGI Sequence Detail 728 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 25
      cDNA 24
      Primer pair 1

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:2146337
    References
    more
    • Summaries
      All 54
      Developmental Gene Expression 4
      Diseases 3
      Gene Ontology 6
      Phenotypes 23
    • Earliest
      J:65974 Kitamura H, et al., MAIL, a novel nuclear IkappaB protein that potentiates LPS-induced IL-6 production. FEBS Lett. 2000 Nov 17;485(1):53-6
    • Latest
      J:261637 Bambouskova M, et al., Electrophilic properties of itaconate and derivatives regulate the IkappaBzeta-ATF3 inflammatory axis. Nature. 2018 Apr;556(7702):501-504

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory