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Nfkbiz
Gene Detail
Symbol

Name
ID
Nfkbiz
nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, zeta
MGI:1931595
Synonyms
Mail
Feature Type
protein coding gene
Genetic Map
Chromosome 16
33.65 cM, cytoband C1.2 - C1.3
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr16:55811375-55838899 bp, - strand
From VEGA annotation of GRCm38

  27525 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:12734  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 western clawed frog

Gene Tree: Nfkbiz

Human
homologs
Human Homolog NFKBIZ, nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta
NCBI Gene ID 64332
neXtProt AC  NX_Q9BYH8
Human Synonyms  IKBZ, INAP, MAIL
Human Chr (Location)  3p12-q12; chr3:101827990-101861025 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous inactivation of this gene may lead to background sensitive prenatal lethality and results in abnormal cytokine secretion, higher IgE levels, ocular surface and perioral skin inflammation accompanied by hair loss, and severe atopic dermatitis-like skin lesions.
 
Human Diseases Modeled Using Mouse Nfkbiz (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(2)
Interactions
Nfkbiz interacts with 214 markers (Mir10a, Mir15b, Mir16-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (4 annotations)
Process inflammatory response, regulation of transcription, DNA-templated, ...
Component nucleus
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (54)    Tissues (54)    Images (5)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 46
RT-PCR 8
cDNA source data(23)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(24) cDNA(23) Primer pair(1)
Microarray probesets(7)
Other database
links
VEGA Gene ModelOTTMUSG00000019996 (Evidence)
Ensembl Gene ModelENSMUSG00000035356 (Evidence)
Entrez Gene80859 (Evidence)
DFCITC1576131, TC1595439, TC1621411, TC1679370
DoTSDT.101397233, DT.101703302, DT.110728278, DT.110728290, DT.40143733, DT.489262
NIA Mouse Gene IndexU037110
Consensus CDS ProjectCCDS28216.1, CCDS49869.1
International Mouse Knockout Project StatusNfkbiz
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000019996 VEGA Gene Model | MGI Sequence Detail 27525 C57BL/6J ±  kb
transcript OTTMUST00000047636 VEGA | MGI Sequence Detail 4115 Not Applicable 
polypeptide OTTMUSP00000021591 VEGA | MGI Sequence Detail 728 Not Applicable 

For the selected sequences
All sequences(64) RefSeq(6) UniProt(1)
Polymorphisms
SNPs within 2kb(446 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002110 Ankyrin repeat
InterPro IPR020683 Ankyrin repeat-containing domain
Protein Ontology PR:000011182 NF-kappa-B inhibitor zeta
References
(Earliest) J:65974 Kitamura H, et al., MAIL, a novel nuclear IkappaB protein that potentiates LPS-induced IL-6 production. FEBS Lett. 2000 Nov 17;485(1):53-6
(Latest) J:200520 Hanihara F, et al., Transcriptional and post-transcriptional regulation of IkappaB-zeta upon engagement of the BCR, TLRs and FcgammaR. Int Immunol. 2013 Sep;25(9):531-44
All references(46)
Disease annotation references (1)
Other
accession IDs
MGI:2146337

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory