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Nfkbiz Gene Detail
Summary
  • Symbol
    Nfkbiz
  • Name
    nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, zeta
  • Synonyms
    Mail
  • Feature Type
    protein coding gene
  • IDs
    MGI:1931595
    NCBI Gene: 80859
  • Alliance
    genome feature page
  • Transcription Start Sites
    26 TSS
  • Regulated by
    Rr372 (1 regulatory region)
Location &
Maps
more
  • Sequence Map
    Chr16:55631740-55659018 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 33.65 cM, cytoband C1.2-C1.3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    963 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1931595
 protein coding gene Chr16:55631738-55659262 (-)
129S1/SvImJ ENSMUSG00200020555
 protein coding gene Chr16:52533434-52560935 (-)
A/J ENSMUSG00195024821
 protein coding gene Chr16:52150663-52178190 (-)
AKR/J ENSMUSG00220019358
 protein coding gene Chr16:52525877-52553408 (-)
BALB/cJ ENSMUSG00180023378
 protein coding gene Chr16:52320158-52347686 (-)
C3H/HeJ ENSMUSG00175017614
 protein coding gene Chr16:52616068-52643593 (-)
C57BL/6NJ ENSMUSG00215012287
 protein coding gene Chr16:52437240-52464767 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020807
 protein coding gene Chr16:52272075-52298668 (-)
CAST/EiJ ENSTCUG00005013410
 protein coding gene Chr16:52666061-52693769 (-)
CBA/J ENSMUSG00210019369
 protein coding gene Chr16:52645550-52674014 (-)
DBA/2J ENSMUSG00185025115
 protein coding gene Chr16:52500194-52527719 (-)
FVB/NJ ENSMUSG00205009443
 protein coding gene Chr16:52290496-52317975 (-)
JF1/MsJ ENSUMUG00000017306
 protein coding gene Chr16:52757711-52786177 (-)
LP/J ENSMUSG00230008613
 protein coding gene Chr16:55062425-55089928 (-)
NOD/ShiLtJ ENSMUSG00190007122
 protein coding gene Chr16:52538367-52565888 (-)
NZO/HlLtJ ENSMUSG00225025934
 protein coding gene Chr16:58160054-58187579 (-)
PWK/PhJ ENSLUMG00010011031
 protein coding gene Chr16:52556689-52584213 (-)
SPRET/EiJ ENSMSPG00010001345
 protein coding gene Chr16:53007697-53035152 (-)
WSB/EiJ ENSIUOG00005008918
 protein coding gene Chr16:52751676-52779159 (-)



Homology
more
  • Human Ortholog
    NFKBIZ, NFKB inhibitor zeta
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NFKBIZ, NFKB inhibitor zeta
  • Synonyms
    ikappaBzeta, I-kappa-B-zeta, IkappaB-zeta, IKBZ, ikB-zeta, INAP, MAIL
  • Links
    NCBI Gene ID: 64332
    UniProt: Q9BYH8

  • Chr Location
    3q12.3; chr3:101827990-101861022 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with Nfkbiz mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
IDs
 View 2 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    47 phenotypes from 3 alleles in 7 genetic backgrounds
    12 phenotypes from multigenic genotypes
    2 images
    46 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous inactivation of this gene may lead to background sensitive prenatal lethality and results in abnormal cytokine secretion, higher IgE levels, ocular surface and perioral skin inflammation accompanied by hair loss, and severe atopic dermatitis-like skin lesions.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    99
  • GO References
    34
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    651
  • Tissues
    54
  • cDNA Data
    24
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 80859 NCBI Gene Model | MGI Sequence Detail 27279 C57BL/6J ±  kb
    transcript NM_030612 RefSeq | MGI Sequence Detail 3869 C57BL/6  
    polypeptide Q9EST8 UniProt | EBI | MGI Sequence Detail 728 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 25
      cDNA 24
      Primer pair 1

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:2146337
    References
    more
    • Summaries
      All 93
      Developmental Gene Expression 4
      Diseases 3
      Gene Ontology 34
      Phenotypes 46
    • Earliest
      J:65974 Kitamura H, et al., MAIL, a novel nuclear IkappaB protein that potentiates LPS-induced IL-6 production. FEBS Lett. 2000 Nov 17;485(1):53-6
    • Latest
      J:391722 Li D, et al., IL-17-driven transcriptional programs in muscle fibroblasts are not required for pathogenesis in murine anti-histidyl-tRNA synthetase (Jo-1) myositis. J Immunol. 2026 Aug 4;215(8)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory