Nfkbiz
Gene Detail

Symbol Name ID

Nfkbiz nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, zeta MGI:1931595

Synonyms

Mail

Feature Type

protein coding gene

Genetic Map

Chromosome 16

33.65 cM, cytoband C1.2 - C1.3
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr16:55811375-55838899 bp, - strand From VEGA annotation of GRCm38   27525 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:12734  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Nfkbiz

Human homologs

Human Homolog		NFKBIZ, nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta
NCBI Gene ID		64332
neXtProt AC		NX_Q9BYH8
Human Synonyms		IKBZ, INAP, MAIL
Human Chr (Location)		3p12-q12; chr3:101546834-101579869 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(5) : Targeted(5)
 

Homozygous inactivation of this gene may lead to background sensitive prenatal lethality and results in abnormal cytokine secretion, higher IgE levels, ocular surface and perioral skin inflammation accompanied by hair loss, and severe atopic dermatitis-like skin lesions.

 
Human Diseases Modeled Using Mouse Nfkbiz (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(2)

Gene Ontology (GO) classifications

All GO classifications: (4 annotations)

Process	inflammatory response, regulation of transcription, DNA-dependent, ...
Component	nucleus

External Resources: FuncBase

Expression

Literature Summary: (4 records)
Data Summary: Results (61)    Tissues (59)    Images (5)
Theiler Stages: 2, 3, 4, 5, 17, 18, 19, 21, 23, 28

Assay Type	Results
RNA in situ	46
RT-PCR	15

cDNA source data(66)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(67) cDNA(66) Primer pair(1)
Microarray probesets(7)

Other database links

VEGA Gene Model	OTTMUSG00000019996 (Evidence)
Ensembl Gene Model	ENSMUSG00000035356 (Evidence)
Entrez Gene	80859 (Evidence)
UniGene	247272
DFCI	TC1576131, TC1595439, TC1621411, TC1679370
DoTS	DT.101397233, DT.101703302, DT.110728278, DT.110728290, DT.40143733, DT.489262
NIA Mouse Gene Index	U037110
Consensus CDS Project	CCDS28216.1, CCDS49869.1
International Mouse Knockout Project Status	Nfkbiz

Sequences

Length	Strain/Species
genomic	OTTMUSG00000019996	VEGA Gene Model | MGI Sequence Detail	27525	C57BL/6J
transcript	OTTMUST00000047636	VEGA | MGI Sequence Detail	4115	Not Applicable
polypeptide	OTTMUSP00000021591	VEGA | MGI Sequence Detail	728	Not Applicable

All sequences(64) RefSeq(6) UniProt(1)

Polymorphisms

SNPs(85 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR002110	Ankyrin repeat
InterPro	IPR020683	Ankyrin repeat-containing domain
Protein Ontology	PR:000011182	NF-kappa-B inhibitor zeta

References

(Earliest) J:65974 Kitamura H, et al., MAIL, a novel nuclear IkappaB protein that potentiates LPS-induced IL-6 production. FEBS Lett. 2000 Nov 17;485(1):53-6
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(44)

Other accession IDs

MGI:2146337