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Nfkbiz Gene Detail
Summary
  • Symbol
    Nfkbiz
  • Name
    nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, zeta
  • Synonyms
    Mail
  • Feature Type
    protein coding gene
  • IDs
    MGI:1931595
    NCBI Gene: 80859
  • Gene Overview
    MyGene.info: NFKBIZ
Location & Maps
more
  • Sequence Map
    Chr16:55811375-55838899 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      27525 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 16, 33.65 cM, cytoband C1.2 - C1.3
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    NFKBIZ, NFKB inhibitor zeta
  • Vertebrate Orthologs
    10
  • Human Ortholog
    NFKBIZ, NFKB inhibitor zeta
    Orthology source: HGNC, HomoloGene
  • Synonyms
    IKBZ, INAP, MAIL
  • Links
    NCBI Gene ID: 64332
    neXtProt AC: NX_Q9BYH8

  • Chr Location
    3p12-q12; chr3:101827990-101861025 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with Nfkbiz mouse models

Human Disease Mouse Models
       Dermatitis, Atopic   OMIM: 603165 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    47 phenotypes from 3 alleles in 7 genetic backgrounds
    12 phenotypes from multigenic genotypes
    2 images
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous inactivation of this gene may lead to background sensitive prenatal lethality and results in abnormal cytokine secretion, higher IgE levels, ocular surface and perioral skin inflammation accompanied by hair loss, and severe atopic dermatitis-like skin lesions.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000019996 VEGA Gene Model | MGI Sequence Detail 27525 C57BL/6J ±  kb
transcript OTTMUST00000047639 VEGA | MGI Sequence Detail 3627 Not Applicable  
polypeptide OTTMUSP00000021593 VEGA | MGI Sequence Detail 728 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    446 from dbSNP Build 142
Protein
Information
less
  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000011182 NF-kappa-B inhibitor zeta
  • InterPro Domains
    IPR002110 Ankyrin repeat
    IPR020683 Ankyrin repeat-containing domain
Molecular
Reagents
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  • All nucleic 24
    cDNA 23
    Primer pair 1

    Microarray probesets 7
Other
Accession IDs
less
MGI:2146337
References
more
  • Summaries
    All 47
    Developmental Gene Expression 4
    Diseases 1
    Gene Ontology 4
    Phenotypes 18
  • Earliest
    J:65974 Kitamura H, et al., MAIL, a novel nuclear IkappaB protein that potentiates LPS-induced IL-6 production. FEBS Lett. 2000 Nov 17;485(1):53-6
  • Latest
    J:227182 Johansen C, et al., IkappaBzeta is a key driver in the development of psoriasis. Proc Natl Acad Sci U S A. 2015 Oct 27;112(43):E5825-33

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory