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Nfkbiz
Gene Detail
Symbol

Name
ID
Nfkbiz
nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, zeta
MGI:1931595
Synonyms
Mail
Feature Type
protein coding gene
Genetic Map
Chromosome 16
33.65 cM, cytoband C1.2 - C1.3
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr16:55811375-55838899 bp, - strand
From VEGA annotation of GRCm38

  27525 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:12734  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 western clawed frog

HCOP human homology predictions: NFKBIZ
Gene Tree: Nfkbiz

Human
homologs
NFKBIZ, nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 64332
neXtProt AC: NX_Q9BYH8

Human Synonyms: IKBZ, INAP, MAIL

Human Chr (Location): 3p12-q12; chr3:101827990-101861025 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Targeted(6)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygous inactivation of this gene may lead to background sensitive prenatal lethality and results in abnormal cytokine secretion, higher IgE levels, ocular surface and perioral skin inflammation accompanied by hair loss, and severe atopic dermatitis-like skin lesions.
 
Human Diseases Modeled in Mice Using Nfkbiz (1)    Mutations Annotated to Human Diseases (1)    Phenotype Images(2)
Interactions
Nfkbiz interacts with 213 markers (Mir10a, Mir15b, Mir16-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (7 annotations)
Process inflammatory response, regulation of transcription, DNA-templated, ...
Component nucleus
Function protein binding, transcription cofactor activity
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (54)    Tissues (54)    Images (5)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 46
RT-PCR 8
cDNA source data(23)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase nfkbiz    NEW 
Molecular
reagents
All nucleic(24) cDNA(23) Primer pair(1)
Microarray probesets(7)
Other database
links
VEGA Gene Model OTTMUSG00000019996 (Evidence)
Ensembl Gene Model ENSMUSG00000035356 (Evidence)
Entrez Gene 80859 (Evidence)
DFCI TC1576131, TC1595439, TC1621411, TC1679370
DoTS DT.101397233, DT.101703302, DT.110728278, DT.110728290, DT.40143733, DT.489262
NIA Mouse Gene Index U037110
Consensus CDS Project CCDS28216.1, CCDS49869.1
International Mouse Phenotyping Consortium Status Nfkbiz
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000019996 VEGA Gene Model | MGI Sequence Detail 27525 C57BL/6J ±  kb
transcript OTTMUST00000047639 VEGA | MGI Sequence Detail 3627 Not Applicable 
polypeptide OTTMUSP00000021593 VEGA | MGI Sequence Detail 728 Not Applicable 

For the selected sequences
All sequences(64) RefSeq(6) UniProt(1)
Polymorphisms
SNPs within 2kb(446 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002110 Ankyrin repeat
InterPro IPR020683 Ankyrin repeat-containing domain
Protein Ontology PR:000011182 NF-kappa-B inhibitor zeta
References
(Earliest) J:65974 Kitamura H, et al., MAIL, a novel nuclear IkappaB protein that potentiates LPS-induced IL-6 production. FEBS Lett. 2000 Nov 17;485(1):53-6
(Latest) J:217074 Hanihara-Tatsuzawa F, et al., Control of Toll-like receptor-mediated T cell-independent type 1 antibody responses by the inducible nuclear protein IkappaB-zeta. J Biol Chem. 2014 Nov 7;289(45):30925-36
All references(48)
Disease annotation references (1)
Other
accession IDs
MGI:2146337

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory