Automated description from the Alliance of Genome Resources (Release 7.1.0)
Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity and transcription coregulator activity. Involved in several processes, including lymphocyte activation involved in immune response; positive regulation of immune response; and response to bacterium. Acts upstream of or within inflammatory response. Is active in nucleus. Is expressed in central nervous system; early conceptus; eye; and genitourinary system. Used to study Stevens-Johnson syndrome and atopic dermatitis. Orthologous to human NFKBIZ (NFKB inhibitor zeta).