Analysis Tools
mortality/aging
|
• Background Sensitivity: 70% of mice die in utero, which is more than on a mixed 129P2/OlaHsd C57BL/6 mixed background
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vision/eye
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• inflammation of the ocular surfaces is accompanied by eye lid swelling, alopecia and abnormal hair growth around the eye
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blepharitis
(
J:141704
)
|
• at 4 to 6 weeks of age, mice develop inflammation of the eye lids
• many CD4+ cells, some CD8+ cells and few CD45R/B220+ cells infiltrate the skin of the eyelids
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|
• 2 weeks after the onset of symptoms, mice exhibit infiltration of the submucosal area of the conjunctiva with inflammatory cells
• inflammatory cells in the conjunctival tissue are CD4+ and CD45%/B220+ while CD8+ cells are only detected in the conjunctival epithelium
|
|
• 2 weeks after the onset of symptoms, mice exhibit severe decrease in the number of goblet cells in the conjunctival epithelia
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immune system
|
• 10 weeks after the onset of symptoms, IgE levels are higher than in wild-type mice
• however, IgE levels prior to 10 weeks after the onset of symptoms is normal
|
|
• inflammation of the ocular surfaces is accompanied by eye lid swelling, alopecia and abnormal hair growth around the eye
|
blepharitis
(
J:141704
)
|
• at 4 to 6 weeks of age, mice develop inflammation of the eye lids
• many CD4+ cells, some CD8+ cells and few CD45R/B220+ cells infiltrate the skin of the eyelids
|
|
• 2 weeks after the onset of symptoms, mice exhibit infiltration of the submucosal area of the conjunctiva with inflammatory cells
• inflammatory cells in the conjunctival tissue are CD4+ and CD45%/B220+ while CD8+ cells are only detected in the conjunctival epithelium
|
|
• at 6 weeks of age, mice exhibit heavy infiltrate of inflammatory cells into the dermis
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dermatitis
(
J:141704
)
|
• mice develop progressive dermatitis that lichenifies
|
|
• at 9 weeks of age, mice exhibit inflammation of the perioral skin
• perioral inflammation is accompanied by erythema with excoriation and partial hair loss
• CD4+ and CD8+ cells infiltrate the dermis and epidermis around the mouth while many CD4+ cells, some CD8+ cells and few CD45R/B220+ cells infiltrate the skin of the eyelids
• however, dorsal and abdominal skin does not develop inflammation
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homeostasis/metabolism
skin edema
(
J:141704
)
|
• at 6 weeks of age, mice exhibit inter- and intracellular edema of the epidermis around the mouth and eyes
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integument
skin edema
(
J:141704
)
|
• at 6 weeks of age, mice exhibit inter- and intracellular edema of the epidermis around the mouth and eyes
|
|
• at 6 weeks of age, mice exhibit heavy infiltrate of inflammatory cells into the dermis
|
dermatitis
(
J:141704
)
|
• mice develop progressive dermatitis that lichenifies
|
|
• at 9 weeks of age, mice exhibit inflammation of the perioral skin
• perioral inflammation is accompanied by erythema with excoriation and partial hair loss
• CD4+ and CD8+ cells infiltrate the dermis and epidermis around the mouth while many CD4+ cells, some CD8+ cells and few CD45R/B220+ cells infiltrate the skin of the eyelids
• however, dorsal and abdominal skin does not develop inflammation
|
|
• eye inflammation is accompanied by abnormal hair growth around the eyes
|
|
• eye and perioral inflammation is accompanied by loss of hair around the sites of inflammation
|
|
• at 6 weeks of age, mice exhibit spongiosis in the epidermis around the mouth and eyes
|
|
• at 6 weeks of age, mice exhibit epidermal hyperplasia around the mouth and eyes
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reddish skin
(
J:141704
)
|
• perioral inflammation is accompanied by erythema with excoriation
|
hematopoietic system
|
• 10 weeks after the onset of symptoms, IgE levels are higher than in wild-type mice
• however, IgE levels prior to 10 weeks after the onset of symptoms is normal
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| Stevens-Johnson syndrome | DOID:0050426 | J:141704 | ||
