Nfkbiz Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Nfkbiz
nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, zeta
MGI:1931595

47 phenotypes from 3 alleles in 7 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Cd79a^tm1(cre)Reth/Cd79a⁺ Nfkbiz^tm1.1Muta/Nfkbiz^tm1.1Muta involves: BALB/c * C57BL/6	normal immune system phenotype	J:194832
Lyz2^tm1(cre)Ifo/Lyz2⁺ Nfkbiz^tm1.1Muta/Nfkbiz^tm1.1Muta involves: 129P2/OlaHsd * C57BL/6	normal immune system phenotype	J:194832
Nfkbiz^tm1.1Muta/Nfkbiz^tm1.1Muta Tg(CAG-cre)13Miya/? involves: C57BL/6	dermatitis	J:194832
	eyelid edema	J:194832
Nfkbiz^tm1.1Muta/Nfkbiz^tm1.1Muta Tg(KRT5-cre)1Tak/? involves: C3H * C57BL/6	dermatitis	J:194832
	increased lacrimal gland apoptosis	J:194832
Nfkbiz^tm1.1Muta/Nfkbiz^tm1.1Muta Tg(Lck-cre)1Jtak/? involves: C57BL/6	normal immune system phenotype	J:194832
Nfkbiz^tm1Aki/Nfkbiz^tm1Aki C.129P2-Nfkbiz^tm1Aki	abnormal epidermal layer morphology	J:141704
	abnormal hair growth	J:141704
	alopecia	J:141704
	blepharitis	J:141704
	conjunctivitis	J:141704
	decreased conjunctiva goblet cell number	J:141704
	dermatitis	J:141704
	epidermal hyperplasia	J:141704
	eye inflammation	J:141704
	increased IgE level	J:141704
	perioral dermatitis	J:141704
	prenatal lethality, incomplete penetrance	J:141704
	reddish skin	J:141704
	skin edema	J:141704
	skin inflammation	J:141704
Nfkbiz^tm1Aki/Nfkbiz^tm1Aki involves: 129P2/OlaHsd	abnormal conjunctiva goblet cell morphology	J:91297
	abnormal cytokine secretion	J:91297
	abnormal immune system organ morphology	J:194832
	abnormal immune system physiology	J:194832
	abnormal leukocyte physiology	J:91297
	abnormal lymph node cell ratio	J:194832
	abnormal lymphocyte morphology	J:194832
	abnormal T-helper 1 cell morphology	J:194832
	abnormal tumor necrosis factor secretion	J:91297
	blepharitis	J:96363
	conjunctivitis	J:96363
	corneal limbitis	J:96363
	decreased conjunctiva goblet cell number	J:96363
	decreased interleukin-6 secretion	J:91297
	decreased interleukin-12 secretion	J:91297
	decreased tear production	J:194832
	dermatitis	J:91297, J:194832
	enlarged lymph nodes	J:194832
	enlarged spleen	J:194832
	eye inflammation	J:96363
	eyelid edema	J:194832
	increased immunoglobulin level	J:194832
	increased lacrimal gland apoptosis	J:194832
	interstitial pneumonia	J:194832
	lacrimal gland inflammation	J:194832
	periocular dermatitis	J:194832
	skin lesions	J:96363
Nfkbiz^tm1Mamo/Nfkbiz^tm1Mamo involves: 129S7/SvEvBrd	abnormal skin condition	J:95040
	abnormal skin morphology	J:95040
	acanthosis	J:95040
	alopecia	J:95040
	dermatitis	J:95040
	excessive scratching	J:95040
	eyelid edema	J:95040
	hyperkeratosis	J:95040
	increased IgE level	J:95040
	parakeratosis	J:95040
	prenatal lethality, incomplete penetrance	J:95040
	scaly skin	J:95040
	spontaneous skin ulceration	J:95040
	thick skin	J:95040

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/23/2024 MGI 6.23