About   Help   FAQ
Targeted Allele Detail
Symbol: Nfkbiztm1Mamo
Name: nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, zeta; targeted mutation 1, Masami Morimatsu
MGI ID: MGI:3525252
Synonyms: MAIL-
Gene: Nfkbiz  Location: Chr16:55631740-55659018 bp, - strand  Genetic Position: Chr16, 33.65 cM, cytoband C1.2 - C1.3
Alliance: Nfkbiztm1Mamo page
Allergic dermatitis in Nfkbiztm1Mamo/Nfkbiztm1Mamo mice

Show the 2 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:95040
Parent Cell Line:  AB2.2 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprt1b-m2
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA targeting vector was used to replace most of exon 4 and all of exons 5-8, the coding sequence for part of the ankyrin repeats I and II, with a neo and to insert a nonsense mutation just downstream of the start codon. (J:95040)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Structures Affected by this Mutation: 5 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Nfkbiz Mutation:  23 strains or lines available
Original:  J:95040 Shiina T, et al., Targeted disruption of MAIL, a nuclear IkappaB protein, leads to severe atopic dermatitis-like disease. J Biol Chem. 2004 Dec 31;279(53):55493-8
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
MGI 6.22
The Jackson Laboratory