Nfkbiz^tm1Mamo
Targeted Allele Detail

Summary

• Symbol: Nfkbiz^tm1Mamo
• Name: nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, zeta; targeted mutation 1, Masami Morimatsu
• MGI ID: MGI:3525252
• Synonyms: MAIL^-
• Gene: Nfkbiz Location: Chr16:55631740-55659018 bp, - strand Genetic Position: Chr16, 33.65 cM, cytoband C1.2 - C1.3
• Alliance: Nfkbiz^tm1Mamo page

Allergic dermatitis in Nfkbiz^tm1Mamo/Nfkbiz^tm1Mamo mice

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:95040
• Parent Cell Line: AB2.2 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A targeting vector was used to replace most of exon 4 and all of exons 5-8, the coding sequence for part of the ankyrin repeats I and II, with a neo and to insert a nonsense mutation just downstream of the start codon. (J:95040)

Disease models

Expression

In Structures Affected by this Mutation:

5 anatomical structures

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nfkbiz Mutation: 23 strains or lines available

References

• Original: J:95040 Shiina T, et al., Targeted disruption of MAIL, a nuclear IkappaB protein, leads to severe atopic dermatitis-like disease. J Biol Chem. 2004 Dec 31;279(53):55493-8
• All: 6 reference(s)