About   Help   FAQ
Sav1
Gene Detail
 Symbol
Name
ID
Sav1
salvador homolog 1 (Drosophila)
MGI:1927144
Synonyms 1700040G09Rik, Salv, WW45
Feature Type protein coding gene
Genetic Map
Chromosome 12
28.94 cM, cytoband C3
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr12:69965012-69987002 bp, - strand
From NCBI annotation of GRCm38

  21991 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:32517  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Sav1

Human
homologs
Human Homolog SAV1, salvador homolog 1 (Drosophila)
NCBI Gene ID 60485
neXtProt AC  NX_Q9H4B6
Human Synonyms  SAV, WW45, WWP4
Human Chr (Location)  14q13-q23; chr14:50633580-50668353 (-)  GRCh38
Alleles
and
phenotypes
All alleles(9) : Targeted(8) Gene trapped(1)
 
Homozygotes for a null allele display fetal growth retardation and lethality, show multiple tissue hyperplasia and dysplasia due to unchecked proliferation and impaired terminal differentiation of epithelial cells, and develop hepatomas. Heterozygotes are prone to tumorigenesis and die prematurely.
 
Gene Ontology
(GO)
classifications
All GO classifications: (18 annotations)
Process hair follicle development, hippo signaling, ...
Component cytoplasm, intracellular, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (12)    Tissues (12)   
Theiler Stages: 10, 18, 23, 25, 28
Assay TypeResults
Northern blot 12
cDNA source data(7)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(7) cDNA(7)
Microarray probesets(7)
Other database
links
Ensembl Gene ModelENSMUSG00000021067 (Evidence)
Entrez Gene64010 (Evidence)
DFCITC1575162, TC1609382
NIA Mouse Gene IndexU034042
PDB2DWV, 2YSB
Consensus CDS ProjectCCDS25956.1
International Mouse Knockout Project StatusSav1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 64010 NCBI Gene Model | MGI Sequence Detail 21991 C57BL/6J ±  kb
transcript NM_022028 RefSeq | MGI Sequence Detail 2524 C57BL/6 
polypeptide Q8VEB2 UniProt | EBI | MGI Sequence Detail 386 Not Applicable 

For the selected sequences
All sequences(20) RefSeq(2) UniProt(1)
Polymorphisms SNPs within 2kb(66 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR011524 SARAH domain
InterPro IPR001202 WW domain
Protein Ontology PR:000014471 protein salvador homolog 1
Graphical View of Protein Domain Structure
References (Earliest) J:65081 Valverde P, Cloning, expression, and mapping of hWW45, a novel human WW domain-containing gene. Biochem Biophys Res Commun. 2000 Oct 5;276(3):990-8
(Latest) J:206316 Heallen T, et al., Hippo signaling impedes adult heart regeneration. Development. 2013 Dec;140(23):4683-90
All references(37)
Other
accession IDs
MGI:1920575

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
04/15/2014
MGI 5.17
The Jackson Laboratory