45 phenotypes from 5 alleles in 7 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Sav1tm1.1Dupa/Sav1tm1.1Dupa Tg(Vil1-cre)997Gum/0 involves: 129P2/OlaHsd * C57BL/6J * SJL	abnormal enterocyte proliferation	J:165471
	abnormal large intestine crypts of Lieberkuhn morphology	J:165471
	abnormal small intestine crypts of Lieberkuhn morphology	J:165471
	colon polyps	J:165471
Sav1tm1.1Gpp/Sav1+ involves: 129S1/Sv	abnormal oval cell morphology	J:231761
	bile duct hyperplasia	J:231761
	increased hepatocellular carcinoma incidence	J:231761
	increased liver adenoma incidence	J:231761
	increased liver tumor incidence	J:231761
Sav1tm1.1Gpp/Sav1tm1.1Gpp involves: 129S1/Sv	prenatal lethality, complete penetrance	J:231761
Sav1tm1.1Rjo/Sav1tm1.1Rjo Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+ involves: 129S6/SvEvTac * C57BL/6 * CD-1 * DBA * SJL	increased carcinoma incidence	J:156531
	increased hepatocellular carcinoma incidence	J:156531
	increased hepatocyte proliferation	J:156531
	increased liver weight	J:156531
Sav1tm1.1Rjo/Sav1tm1.1Rjo Tg(CAG-cre/Esr1*)5Amc/0 involves: 129S6/SvEvTac * C57BL/6 * CBA * CD-1 * SJL	increased liver tumor incidence	J:156531
Sav1tm1.1Rjo/Sav1tm1.1Rjo Tg(MMTV-cre)4Mam/0 involves: 129S6/SvEvTac * C57BL/6 * CD-1 * FVB/N * SJL	increased liver tumor incidence	J:156531
Sav1tm1Dlim/Sav1+ involves: 129S1/Sv * 129X1/SvJ	increased hepatoma incidence	J:160325
	increased liver tumor incidence	J:160325
	increased lymphoma incidence	J:160325
	increased osteosarcoma incidence	J:160325
	increased ovary tumor incidence	J:160325
	premature death	J:160325
Sav1tm1Dlim/Sav1tm1Dlim involves: 129S1/Sv * 129X1/SvJ	abnormal enterocyte morphology	J:134270
	abnormal enterocyte proliferation	J:134270
	abnormal epidermis stratum basale morphology	J:134270
	abnormal epidermis stratum granulosum morphology	J:134270
	abnormal intestinal enteroendocrine cell morphology	J:134270
	abnormal intestinal goblet cell morphology	J:134270
	abnormal keratinocyte differentiation	J:134270
	abnormal large intestine crypts of Lieberkuhn morphology	J:134270
	abnormal lung development	J:134270
	abnormal placental labyrinth vasculature morphology	J:134270
	abnormal small intestinal microvillus morphology	J:134270
	abnormal small intestinal villus morphology	J:134270
	decreased survivor rate	J:134270
	disorganized suprabasal layer	J:134270
	epidermal hyperplasia	J:134270
	fetal growth retardation	J:134270
	impaired skin barrier function	J:134270
	increased enterocyte cell number	J:134270
	increased liver tumor incidence	J:160325
	lethality throughout fetal growth and development, incomplete penetrance	J:134270
	lung epithelium hyperplasia	J:134270
	parakeratosis	J:134270
	premature death	J:160325
	retina hyperplasia	J:134270
	underdeveloped hair follicles	J:134270
Sav1tm2.1Dlim/Sav1tm2.1Dlim Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+ involves: C57BL/6 * DBA	abnormal hepatocyte morphology	J:160325
	abnormal liver morphology	J:160325
	abnormal oval cell morphology	J:160325
	abnormal oval cell physiology	J:160325
	abnormal portal lobule morphology	J:160325
	enlarged liver	J:160325
	increased hepatocellular carcinoma incidence	J:238319
	increased hepatoma incidence	J:160325
	increased liver weight	J:160325
	normal liver/biliary system phenotype	J:160325