Errfi1
Gene Detail

Symbol Name ID

Errfi1 ERBB receptor feedback inhibitor 1 MGI:1921405

Synonyms

1300002F13Rik, Mig-6, RALT

Feature Type

protein coding gene

Genetic Map

Chromosome 4

81.50 cM, cytoband E1
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr4:150853919-150868892 bp, + strand From VEGA annotation of GRCm38   14974 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:10344  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Errfi1

Human homologs

Human Homolog		ERRFI1, ERBB receptor feedback inhibitor 1
NCBI Gene ID		54206
neXtProt AC		NX_Q9UJM3
Human Synonyms		GENE-33, MIG6, MIG-6, RALT
Human Chr (Location)		1p36; chr1:8071779-8086393 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(11) : Targeted(6) Gene trapped(5)
 

Homozygous inactivation of this gene may lead to premature death, delayed eyelid opening, epidermal hyperplasia, degenerative joint disease, skin or lung cancer, gastrointestinal tract tumors, increased susceptibility to chemically-induced tumors, and impaired lung development and vascularization.

 
Human Diseases Modeled Using Mouse Errfi1 (2)    Alleles Annotated to Human Diseases(2)    Phenotype Images(7)

Gene Ontology (GO) classifications

All GO classifications: (22 annotations)

Process	lung alveolus development, lung epithelium development, ...
Component	cytoplasm, cytosol, ...
Function	kinase binding, protein binding, ...

External Resources: FuncBase

Expression

Literature Summary: (2 records)
Data Summary: Results (27)    Tissues (11)    Images (15)
Theiler Stages: 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
Immunohistochemistry	13
RT-PCR	14

cDNA source data(216)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(217) cDNA(216) Primer pair(1)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000010157 (Evidence)
Ensembl Gene Model	ENSMUSG00000028967 (Evidence)
Entrez Gene	74155 (Evidence)
UniGene	318841
DFCI	TC1572440
DoTS	DT.55276705, DT.87069635, DT.94411279, DT.94411283
NIA Mouse Gene Index	U005142
Consensus CDS Project	CCDS18974.1
International Mouse Knockout Project Status	Errfi1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000010157	VEGA Gene Model | MGI Sequence Detail	14974	C57BL/6J
transcript	OTTMUST00000023606	VEGA | MGI Sequence Detail	3043	Not Applicable
polypeptide	OTTMUSP00000010785	VEGA | MGI Sequence Detail	461	Not Applicable

All sequences(41) RefSeq(2) UniProt(3)

Polymorphisms

SNPs(55 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR015116	Cdc42 binding domain like
InterPro	IPR021619	EGFR receptor inhibitor Mig-6
Protein Ontology	PR:000007191	ERBB receptor feedback inhibitor 1

References

(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:191071 Petzold KM, et al., Rho signalling restriction by the RhoGAP Stard13 integrates growth and morphogenesis in the pancreas. Development. 2013 Jan 1;140(1):126-35
All references(50)

Other accession IDs

MGI:2140358