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Errfi1
Gene Detail
 Symbol
Name
ID
Errfi1
ERBB receptor feedback inhibitor 1
MGI:1921405
Synonyms 1300002F13Rik, Mig-6, RALT
Feature Type protein coding gene
Genetic Map
Chromosome 4
81.50 cM, cytoband E1
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr4:150853919-150868892 bp, + strand
From VEGA annotation of GRCm38

  14974 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:10344  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

Gene Tree: Errfi1

Human
homologs
Human Homolog ERRFI1, ERBB receptor feedback inhibitor 1
NCBI Gene ID 54206
neXtProt AC  NX_Q9UJM3
Human Synonyms  GENE-33, MIG6, MIG-6, RALT
Human Chr (Location)  1p36; chr1:8011719-8026333 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(15) : Gene trapped(5) Targeted(10)
Genomic Mutations involving Errfi1 (2)
Incidental mutations (data from APF )
 
Homozygous inactivation of this gene may lead to premature death, delayed eyelid opening, epidermal hyperplasia, degenerative joint disease, skin or lung cancer, gastrointestinal tract tumors, increased susceptibility to chemically-induced tumors, and impaired lung development and vascularization.
 
Human Diseases Modeled Using Mouse Errfi1 (2)    Alleles Annotated to Human Diseases(2)    Phenotype Images(7)
Interactions
Errfi1 interacts with 282 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (22 annotations)
Process lung alveolus development, lung epithelium development, ...
Component cytoplasm, cytosol, ...
Function kinase binding, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (27)    Tissues (14)    Images (15)
Theiler Stages: 21, 22, 23, 24, 25, 26, 27, 28
Assay TypeResults
Immunohistochemistry 13
RT-PCR 14
cDNA source data(217)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(218) cDNA(217) Primer pair(1)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000010157 (Evidence)
Ensembl Gene ModelENSMUSG00000028967 (Evidence)
Entrez Gene74155 (Evidence)
UniGene318841
DFCITC1572440
DoTSDT.55276705, DT.87069635, DT.94411279, DT.94411283
NIA Mouse Gene IndexU005142
Consensus CDS ProjectCCDS18974.1
International Mouse Knockout Project StatusErrfi1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000010157 VEGA Gene Model | MGI Sequence Detail 14974 C57BL/6J ±  kb
transcript OTTMUST00000023607 VEGA | MGI Sequence Detail 3036 Not Applicable 
polypeptide OTTMUSP00000010786 VEGA | MGI Sequence Detail 461 Not Applicable 

For the selected sequences
All sequences(45) RefSeq(6) UniProt(3)
Polymorphisms SNPs within 2kb(89 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR015116 Cdc42 binding domain like
InterPro IPR021619 EGFR receptor inhibitor Mig-6
Protein Ontology PR:000007191 ERBB receptor feedback inhibitor 1
References (Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:206807 Staal B, et al., Cartilage-specific deletion of Mig-6 results in osteoarthritis-like disorder with excessive articular chondrocyte proliferation. Proc Natl Acad Sci U S A. 2014 Feb 18;111(7):2590-5
All references(53)
Disease annotation references (2)
Other
accession IDs
MGI:2140358

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory