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Fryl Gene Detail
Summary
  • Symbol
    Fryl
  • Name
    FRY like transcription coactivator
  • Synonyms
    2310004H21Rik, 2510002A14Rik, 9030227G01Rik, mKIAA0826
  • Feature Type
    protein coding gene
  • IDs
    MGI:1919563
    NCBI Gene: 72313
  • Alliance
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:73020191-73256628 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 38.44 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1891 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1919563
protein coding gene Chr5:73019987-73256628 (-)
129S1/SvImJ MGP_129S1SvImJ_G0029622
protein coding gene Chr5:73000751-73247562 (-)
A/J MGP_AJ_G0029590
protein coding gene Chr5:70268764-70506247 (-)
AKR/J MGP_AKRJ_G0029538
protein coding gene Chr5:72543731-72786936 (-)
BALB/cJ MGP_BALBcJ_G0029599
protein coding gene Chr5:70976893-71224611 (-)
C3H/HeJ MGP_C3HHeJ_G0029322
protein coding gene Chr5:72906801-73191307 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030053
protein coding gene Chr5:75987513-76260571 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027293
protein coding gene Chr5:65968315-66201952 (-)
CAST/EiJ MGP_CASTEiJ_G0028730
protein coding gene Chr5:71978635-72250123 (-)
CBA/J MGP_CBAJ_G0029289
protein coding gene Chr5:78435908-78745993 (-)
DBA/2J MGP_DBA2J_G0029436
protein coding gene Chr5:70319965-70585643 (-)
FVB/NJ MGP_FVBNJ_G0029397
protein coding gene Chr5:69485162-69722187 (-)
LP/J MGP_LPJ_G0029522
protein coding gene Chr5:73435054-73685691 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0029424
protein coding gene Chr5:81786720-82043782 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030086
protein coding gene Chr5:72092168-72335335 (-)
PWK/PhJ MGP_PWKPhJ_G0028453
protein coding gene Chr5:69286877-69551305 (-)
SPRET/EiJ MGP_SPRETEiJ_G0028288
protein coding gene Chr5:71443634-71684803 (-)
WSB/EiJ MGP_WSBEiJ_G0028810
protein coding gene Chr5:72370224-72626147 (-)



Homology
more
  • Human Ortholog
    FRYL, FRY like transcription coactivator
  • Vertebrate Orthologs
    10
  • Human Ortholog
    FRYL, FRY like transcription coactivator
    Orthology source: HomoloGene, HGNC
  • Synonyms
    AF4p12, KIAA0826, MOR2
  • Links
    NCBI Gene ID: 285527
    neXtProt AC: NX_O94915
    UniProt: O94915

  • Chr Location
    4p11; chr4:48497363-48780312 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 103956
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: FRYL
  • Gene Tree
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    18 phenotypes from 2 alleles in 2 genetic backgrounds
    268 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Most mice homozygous for a knock-out allele exhibit postnatal lethality and defects in kidney development; rare survivors display growth retardation, decreased body weight, and premature death associated with chronic hydronephrosis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 72313 NCBI Gene Model | MGI Sequence Detail 236438 C57BL/6J ±  kb
    transcript NM_028194 RefSeq | MGI Sequence Detail 11488 C57BL/6  
    polypeptide NP_082470 RefSeq | MGI Sequence Detail 3007 C57BL/6  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      15 Sequences
    • InterPro Domains
      IPR016024 Armadillo-type fold
      IPR029473 Cell morphogenesis central region
      IPR025481 Cell morphogenesis protein C-terminal
      IPR025614 Cell morphogenesis protein N-terminal
    Molecular
    Reagents
    less
    • All nucleic 145
      cDNA 145

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGI:1914271, MGI:1922825, MGI:2141007, MGI:2443838
    References
    more
    • Summaries
      All 294
      Developmental Gene Expression 2
      Diseases 1
      Gene Ontology 3
      Phenotypes 268
    • Earliest
      J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
    • Latest
      J:266037 Jain S, et al., Melanotan II causes hypothermia in mice by activation of mast cells and stimulation of histamine 1 receptors. Am J Physiol Endocrinol Metab. 2018 Sep 1;315(3):E357-E366

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory