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Alkbh4 Gene Detail
Summary
  • Symbol
    Alkbh4
  • Name
    alkB homolog 4, lysine demethylase
  • Synonyms
    2010004B12Rik, Abj4
  • Feature Type
    protein coding gene
  • IDs
    MGI:1919291
    NCBI Gene: 72041
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr5:136136146-136141615 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      5470 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 75.82 cM, cytoband G1
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    ALKBH4, alkB homolog 4, lysine demethylase
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ALKBH4, alkB homolog 4, lysine demethylase
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ABH4
  • Links
    NCBI Gene ID: 54784
    neXtProt AC: NX_Q9NXW9
    UniProt: Q9NXW9

  • Chr Location
    7q22.1; chr7:102456220-102464874 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 9747
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: ALKBH4
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 2 alleles in 2 genetic backgrounds
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a targeted mutation exhibit lethality prior to weaning. Mice homozygous for a floxed allele activated in mouse embryonic fibroblasts exhibit decreased migration and impaired cytokinesis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000025439 VEGA Gene Model | MGI Sequence Detail 5470 C57BL/6J ±  kb
transcript OTTMUST00000062642 VEGA | MGI Sequence Detail 1773 Not Applicable  
polypeptide OTTMUSP00000030914 VEGA | MGI Sequence Detail 300 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    4 from dbSNP Build 142
Protein
Information
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  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000003951 alpha-ketoglutarate-dependent dioxygenase alkB homolog 4
  • EC
  • InterPro Domains
    IPR032857 Alpha-ketoglutarate-dependent dioxygenase alkB homologue 4
    IPR037151 Alpha-ketoglutarate-dependent dioxygenase AlkB-like superfamily
Molecular
Reagents
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  • All nucleic 15
    Genomic 1
    cDNA 14

    Microarray probesets 5
References
more
  • Summaries
    All 32
    Developmental Gene Expression 1
    Gene Ontology 4
    Phenotypes 7
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:221080 Nilsen A, et al., ALKBH4 depletion in mice leads to spermatogenic defects. PLoS One. 2014;9(8):e105113

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
12/05/2017
MGI 6.11
The Jackson Laboratory