Atp8b1
Gene Detail

Symbol Name ID

Atp8b1 ATPase, class I, type 8B, member 1 MGI:1859665

Synonyms

FIC1, Ic

Feature Type

protein coding gene

Genetic Map

Chromosome 18

37.49 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr18:64528979-64661000 bp, - strand From NCBI annotation of GRCm38   132022 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:21151  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 zebrafish

Gene Tree: Atp8b1

Human homologs

Human Homolog		ATP8B1, ATPase, aminophospholipid transporter, class I, type 8B, member 1
NCBI Gene ID		5205
neXtProt AC		NX_O43520
Human Synonyms		ATPIC, BRIC, FIC1, ICP1, PFIC, PFIC1
Human Chr (Location)		18q21.31; chr18:55313658-55470327 (-)  GRCh37.p10
Disease Associations		(2) Diseases Associated with Human ATP8B1

Alleles and phenotypes

All alleles(3) : Targeted(3)
 

Homozygous mice display abnormal bile salt homeostasis, normal bile secretion, and an impaired ability to handle increased bile salt loading resulting in liver damage and weight loss on a bile salt supplemented diet.

 

Gene Ontology (GO) classifications

All GO classifications: (22 annotations)

Process	bile acid metabolic process, cation transport, ...
Component	apical plasma membrane, brush border membrane, ...
Function	ATP binding, cation-transporting ATPase activity, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (1 records)
Data Summary: Results (14)    Tissues (14)   
Theiler Stages: 25, 28

Assay Type	Results
RNA in situ	14

cDNA source data(7)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(8) Genomic(1) cDNA(7)
Microarray probesets(1)

Other database links

Ensembl Gene Model	ENSMUSG00000039529 (Evidence)
Entrez Gene	54670 (Evidence)
DFCI	TC1589448, TC1635472, TC1635950
DoTS	DT.101716214
NIA Mouse Gene Index	U038499
EC	3.6.3.1
Consensus CDS Project	CCDS29304.1
International Mouse Knockout Project Status	Atp8b1

Sequences

Length	Strain/Species
genomic	54670	NCBI Gene Model | MGI Sequence Detail	132022	C57BL/6J
transcript	NM_001001488	RefSeq | MGI Sequence Detail	6440	C57BL/6
polypeptide	Q148W0	UniProt | EBI | MGI Sequence Detail	1251	Not Applicable

All sequences(23) RefSeq(2) UniProt(2)

Polymorphisms

SNPs(612 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR023306	ATPase, cation-transporting, domain N
InterPro	IPR008250	ATPase, P-type, ATPase-associated domain
InterPro	IPR023299	ATPase, P-type, cytoplasmic domain N
InterPro	IPR023300	ATPase, P-type, cytoplasmic transduction domain A
InterPro	IPR001757	ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter
InterPro	IPR006539	ATPase, P-type, phospholipid-translocating, flippase
InterPro	IPR018303	ATPase, P-type phosphorylation site
InterPro	IPR023214	HAD-like domain
Protein Ontology	PR:000032689	probable phospholipid-transporting ATPase IC

Graphical View of Protein Domain Structure

References

(Earliest) J:59384 Halleck MS, et al., Differential expression of putative transbilayer amphipath transporters. Physiol Genomics. 1999 Nov 11;1(3):139-50
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(34)

Other accession IDs

MGI:2147231