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Atp8b1
Gene Detail
Symbol

Name
ID
Atp8b1
ATPase, class I, type 8B, member 1
MGI:1859665
Synonyms
FIC1, Ic
Feature Type
protein coding gene
Genetic Map
Chromosome 18
37.49 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr18:64528979-64661000 bp, - strand
From Ensembl annotation of GRCm38

  132022 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:21151  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: ATP8B1
Gene Tree: Atp8b1

Human
homologs
ATP8B1, ATPase, aminophospholipid transporter, class I, type 8B, member 1
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 5205
neXtProt AC: NX_O43520

Human Synonyms: ATPIC, BRIC, FIC1, ICP1, PFIC, PFIC1

Human Chr (Location): 18q21.31; chr18:57646426-57803822 (-)  GRCh38.p2

Disease Associations: (3) Diseases Associated with Human ATP8B1

Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygous mice display abnormal bile salt homeostasis, normal bile secretion, and an impaired ability to handle increased bile salt loading resulting in liver damage and weight loss on a bile salt supplemented diet.
 
Mutations Annotated to Human Diseases (1)   
Interactions
Atp8b1 interacts with 324 markers (Mir1b, Mir7-1, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (37 annotations)
Process bile acid metabolic process, drug transmembrane transport, ...
Component apical plasma membrane, brush border membrane, ...
Function ATP binding, cardiolipin binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (14)    Tissues (14)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 14
cDNA source data(7)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase atp8b1    NEW 
Molecular
reagents
All nucleic(8) Genomic(1) cDNA(7)
Microarray probesets(1)
Other database
links
Ensembl Gene Model ENSMUSG00000039529 (Evidence)
Entrez Gene 54670 (Evidence)
DFCI TC1589448, TC1635472, TC1635950
DoTS DT.101716214
NIA Mouse Gene Index U038499
EC 3.6.3.1
Consensus CDS Project CCDS29304.1
International Mouse Phenotyping Consortium Status Atp8b1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000039529 Ensembl Gene Model | MGI Sequence Detail 132022 C57BL/6J ±  kb
transcript ENSMUST00000025482 Ensembl | MGI Sequence Detail 6440 Not Applicable 
polypeptide ENSMUSP00000025482 Ensembl | MGI Sequence Detail 1251 Not Applicable 

For the selected sequences
All sequences(25) RefSeq(4) UniProt(2)
Polymorphisms
SNPs within 2kb(778 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001757 Cation-transporting P-type ATPase
InterPro IPR023214 HAD-like domain
InterPro IPR006539 Phospholipid-transporting P-type ATPase, subfamily IV
InterPro IPR008250 P-type ATPase, A domain
InterPro IPR023299 P-type ATPase, cytoplasmic domain N
InterPro IPR018303 P-type ATPase, phosphorylation site
Protein Ontology PR:000032689 phospholipid-transporting ATPase IC
References
(Earliest) J:59384 Halleck MS, et al., Differential expression of putative transbilayer amphipath transporters. Physiol Genomics. 1999 Nov 11;1(3):139-50
(Latest) J:215915 Kunne C, et al., Hepatic cytochrome P450 deficiency in mouse models for intrahepatic cholestasis predispose to bile salt-induced cholestasis. Lab Invest. 2014 Oct;94(10):1103-13
All references(35)
Disease annotation references (1)
Other
accession IDs
MGI:2147231

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory