Symbol
Name
ID

Atp8b1
ATPase, class I, type 8B, member 1
MGI:1859665

Phenotype annotations related to homeostasis/metabolism

Darker colors indicate more annotations

Human Phenotypes	Conjugated hyperbilirubinemia	Increased serum bile acid concentration	Increased serum bile acid concentration during pregnancy	Elevated circulating hepatic transaminase concentration	Abnormal liver function tests during pregnancy
Disease(s) Associated with ATP8B1	Conjugated hyperbilirubinemia	Increased serum bile acid concentration	Increased serum bile acid concentration during pregnancy	Elevated circulating hepatic transaminase concentration	Abnormal liver function tests during pregnancy
benign recurrent intrahepatic cholestasis 1
intrahepatic cholestasis of pregnancy 1
progressive familial intrahepatic cholestasis 1

Mouse Phenotypes

increased circulating bilirubin level

decreased fasting circulating glucose level

decreased circulating glucose level

decreased circulating HDL cholesterol level

decreased circulating triglyceride level

increased circulating potassium level

increased circulating alanine transaminase level

increased circulating alkaline phosphatase level

increased circulating aspartate transaminase level

improved glucose tolerance

abnormal bile salt level

Availability

Mouse Genotype

Atp8b1^em1(IMPC)Tcp/Atp8b1^em1(IMPC)Tcp

Atp8b1^tm1Nbf/Atp8b1^tm1Nbf

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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