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Portm1Wolf
Targeted Allele Detail
Summary
Symbol: Portm1Wolf
Name: cytochrome p450 oxidoreductase; targeted mutation 1, C Roland Wolf
MGI ID: MGI:2656919
Synonyms: CPRlox, HRN, PORlox
Gene: Por  Location: Chr5:135698894-135764180 bp, + strand  Genetic Position: Chr5, 75.34 cM, cytoband G1
Alliance: Portm1Wolf page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:82951
Parent Cell Line:  GK129 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA floxed neo cassette was introduced into intron 4 and a single loxP site was introduced into intron 15 via homologous recombination. (J:82951)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Por Mutation:  67 strains or lines available
Notes
The HRN (Hepatic cytochrome P450 Reductase Null) synonym is a trade mark for the conditional liver knockout of homozygous mice produced in conjunction with Tg(Alb-cre)21Mgn.
References
Original:  J:82951 Henderson CJ, et al., Inactivation of the hepatic cytochrome p450 system by conditional deletion of hepatic cytochrome p450 reductase. J Biol Chem. 2003 Apr 11;278(15):13480-6
All:  10 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
01/17/2023
MGI 6.22
The Jackson Laboratory