Sequence Detail

ID/Version

Q148W0 Q3U010 Q6R964 (UniProt | EBI)

Last sequence update: 2009-05-05
Last annotation update: 2024-01-24

Sequence description from provider

RecName: Full=Phospholipid-transporting ATPase IC {ECO:0000305}; EC=7.6.2.1 {ECO:0000250|UniProtKB:O43520};AltName: Full=ATPase class I type 8B member 1;AltName: Full=P4-ATPase flippase complex alpha subunit ATP8B1;

Provider

SWISS-PROT

Sequence

Polypeptide 1251 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Atp8b1	ATPase, class I, type 8B, member 1	54	97	3	7

Sequence references in MGI

J:89817 Pawlikowska L, et al., A mouse genetic model for familial cholestasis caused by ATP8B1 mutations reveals perturbed bile salt homeostasis but no impairment in bile secretion. Hum Mol Genet. 2004 Apr 15;13(8):881-92
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:150079 Stapelbroek JM, et al., ATP8B1 is essential for maintaining normal hearing. Proc Natl Acad Sci U S A. 2009 Jun 16;106(24):9709-14
J:157936 Shah S, et al., Strain background modifies phenotypes in the ATP8B1-deficient mouse. PLoS One. 2010;5(2):e8984
J:211244 Ray NB, et al., Dynamic regulation of cardiolipin by the lipid pump Atp8b1 determines the severity of lung injury in experimental pneumonia. Nat Med. 2010 Oct;16(10):1120-7
J:227543 Bruurs LJ, et al., ATP8B1-mediated spatial organization of Cdc42 signaling maintains singularity during enterocyte polarization. J Cell Biol. 2015 Sep 28;210(7):1055-63
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89