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Defb3
Gene Detail
Symbol

Name
ID
Defb3
defensin beta 3
MGI:1351612
Synonyms
mBD-3
Feature Type
protein coding gene
Genetic Map
Chromosome 8
10.35 cM, cytoband A4
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr8:19293360-19295291 bp, + strand
From VEGA annotation of GRCm38

  1932 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
Protein SuperFamily: crotamine
Gene Tree: Defb3
Mutations,
alleles, and
phenotypes
All mutations/alleles(2) : Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibits increased susceptibility to P. aeruginosa- or F. solani-induced keratitis.
 
Interactions
Defb3 interacts with 15 markers (Mir103-1, Mir103-2, Mir107, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (5 annotations)
Process defense response, defense response to bacterium
Component extracellular region
External Resources: FuncBase
Expression
Literature Summary: (2 records)
cDNA source data(4)
External Resources: GEO   Expression Atlas
Molecular
reagents
All nucleic(9) Genomic(4) cDNA(4) Primer pair(1)
Microarray probesets(2)
Other database
links
VEGA Gene ModelOTTMUSG00000020668 (Evidence)
Ensembl Gene ModelENSMUSG00000039775 (Evidence)
Entrez Gene27358 (Evidence)
UniGene103651
DFCITC1592077
DoTSDT.110879328
Consensus CDS ProjectCCDS40258.1
International Mouse Knockout Project StatusDefb3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000020668 VEGA Gene Model | MGI Sequence Detail 1932 C57BL/6J ±  kb
transcript OTTMUST00000048942 VEGA | MGI Sequence Detail 275 Not Applicable 
polypeptide OTTMUSP00000022575 VEGA | MGI Sequence Detail 63 Not Applicable 

For the selected sequences
All sequences(18) RefSeq(2) UniProt(1)
Polymorphisms
SNPs within 2kb(85 from dbSNP Build 137)    SNPs within 2kb including multiple locations(95)
Protein-related
information
ResourceIDDescription
InterPro IPR006080 Beta defensin/Neutrophil defensin
InterPro IPR001855 Beta defensin type
Protein Ontology PR:000006806 beta-defensin 3
References
(Earliest) J:55859 Bals R, et al., Mouse beta-defensin 3 is an inducible antimicrobial peptide expressed in the epithelia of multiple organs. Infect Immun. 1999 Jul;67(7):3542-7
(Latest) J:199719 Kolar SS, et al., Protective role of murine beta-defensins 3 and 4 and cathelin-related antimicrobial peptide in Fusarium solani keratitis. Infect Immun. 2013 Aug;81(8):2669-77
All references(29)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/11/2014
MGI 5.20
The Jackson Laboratory