Defb3
Gene Detail

Symbol Name ID

Defb3 defensin beta 3 MGI:1351612

Synonyms

mBD-3

Feature Type

protein coding gene

Genetic Map

Chromosome 8

10.35 cM, cytoband A4
Detailed Genetic Map ± 1 cM


Mapping data(6)

Sequence Map

Chr8:19293360-19295291 bp, + strand From VEGA annotation of GRCm38   1932 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Mammalian homology

Protein SuperFamily: crotamine
Gene Tree: Defb3

Alleles and phenotypes

All alleles(1) : Targeted(1)
 

Mice homozygous for disruptions in this gene display a normal phenotype.

 

Gene Ontology (GO) classifications

All GO classifications: (5 annotations)

Process	defense response, defense response to bacterium
Component	extracellular region

External Resources: FuncBase

Expression

Literature Summary: (2 records)
cDNA source data(4)
External Resources: GEO   ArrayExpress

Molecular reagents

All nucleic(9) Genomic(4) cDNA(4) Primer pair(1)
Microarray probesets(2)

Other database links

VEGA Gene Model	OTTMUSG00000020668 (Evidence)
Ensembl Gene Model	ENSMUSG00000039775 (Evidence)
Entrez Gene	27358 (Evidence)
UniGene	103651
DFCI	TC1592077
DoTS	DT.110879328
Consensus CDS Project	CCDS40258.1
International Mouse Knockout Project Status	Defb3

Sequences

Length	Strain/Species
genomic	OTTMUSG00000020668	VEGA Gene Model | MGI Sequence Detail	1932	C57BL/6J
transcript	OTTMUST00000048942	VEGA | MGI Sequence Detail	275	Not Applicable
polypeptide	OTTMUSP00000022575	VEGA | MGI Sequence Detail	63	Not Applicable

All sequences(18) RefSeq(2) UniProt(1)

Polymorphisms

SNPs(51 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR006080	Beta defensin/Neutrophil defensin
InterPro	IPR001855	Beta defensin type
Protein Ontology	PR:000006806	beta-defensin 3

References

(Earliest) J:55859 Bals R, et al., Mouse beta-defensin 3 is an inducible antimicrobial peptide expressed in the epithelia of multiple organs. Infect Immun. 1999 Jul;67(7):3542-7
(Latest) J:168725 Augustin DK, et al., Role of defensins in corneal epithelial barrier function against Pseudomonas aeruginosa traversal. Infect Immun. 2011 Feb;79(2):595-605
All references(28)