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Defb3 Gene Detail
Summary
  • Symbol
    Defb3
  • Name
    defensin beta 3
  • Synonyms
    mBD-3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1351612
    NCBI Gene: 27358
  • Alliance
Location &
Maps
more
  • Sequence Map
    Chr8:19293360-19295291 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 10.35 cM, cytoband A4
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    84 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1351612
protein coding gene Chr8:19293360-19295339 (.)
129S1/SvImJ MGP_129S1SvImJ_G0033419
protein coding gene Chr8:16767877-16769821 (+)
A/J MGP_AJ_G0033400
protein coding gene Chr8:16233930-16235874 (+)
AKR/J MGP_AKRJ_G0033330
protein coding gene Chr8:16708355-16710286 (+)
BALB/cJ MGP_BALBcJ_G0033400
protein coding gene Chr8:16344234-16346178 (+)
C3H/HeJ MGP_C3HHeJ_G0033112
protein coding gene Chr8:16879280-16881224 (+)
C57BL/6NJ MGP_C57BL6NJ_G0033914
protein coding gene Chr8:17318576-17320507 (+)
CAROLI/EiJ no annotation
CAST/EiJ MGP_CASTEiJ_G0032435
protein coding gene Chr8:16785361-16787288 (+)
CBA/J MGP_CBAJ_G0033086
protein coding gene Chr8:18117337-18119281 (+)
DBA/2J MGP_DBA2J_G0033240
protein coding gene Chr8:16147206-16149150 (+)
FVB/NJ MGP_FVBNJ_G0033188
protein coding gene Chr8:16163758-16165702 (+)
LP/J MGP_LPJ_G0033333
protein coding gene Chr8:16833669-16835600 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033225
protein coding gene Chr8:18222992-18224936 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0033931
protein coding gene Chr8:16696819-16698750 (+)
PWK/PhJ MGP_PWKPhJ_G0032148
protein coding gene Chr8:16367771-16369717 (+)
SPRET/EiJ MGP_SPRETEiJ_G0031989
protein coding gene Chr8:16620589-16622556 (+)
WSB/EiJ MGP_WSBEiJ_G0032552
protein coding gene Chr8:16783116-16785047 (+)



Homology
less
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 2 alleles in 2 genetic backgrounds
    3 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibits increased susceptibility to P. aeruginosa- or F. solani-induced keratitis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000039775 Ensembl Gene Model | MGI Sequence Detail 1932 C57BL/6J ±  kb
    transcript ENSMUST00000033852 Ensembl | MGI Sequence Detail 275 Not Applicable  
    polypeptide ENSMUSP00000033852 Ensembl | MGI Sequence Detail 63 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 10
      Genomic 4
      cDNA 4
      Primer pair 2

      Microarray probesets 2
    References
    more
    • Summaries
      All 33
      Developmental Gene Expression 4
      Gene Ontology 6
      Phenotypes 3
    • Earliest
      J:55859 Bals R, et al., Mouse beta-defensin 3 is an inducible antimicrobial peptide expressed in the epithelia of multiple organs. Infect Immun. 1999 Jul;67(7):3542-7
    • Latest
      J:252739 Williams H, et al., Cutaneous Nod2 Expression Regulates the Skin Microbiome and Wound Healing in a Murine Model. J Invest Dermatol. 2017 Nov;137(11):2427-2436

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    12/11/2018
    MGI 6.13
    The Jackson Laboratory