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Stk11 Gene Detail
Summary
  • Symbol
    Stk11
  • Name
    serine/threonine kinase 11
  • Synonyms
    Lkb1, Par-4
  • Feature Type
    protein coding gene
  • IDs
    MGI:1341870
    NCBI Gene: 20869
  • Gene Overview
    MyGene.info: STK11
Location & Maps
more
  • Sequence Map
    Chr10:80115803-80130682 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      14880 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 39.72 cM
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    STK11, serine/threonine kinase 11
  • Vertebrate Orthologs
    9
  • Human Ortholog
    STK11, serine/threonine kinase 11
    Orthology source: HGNC, HomoloGene
  • Synonyms
    hLKB1, LKB1, PJS
  • Links
    NCBI Gene ID: 6794
    neXtProt AC: NX_Q15831

  • Chr Location
    19p13.3; chr19:1205799-1228435 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 393
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: STK11
  • Gene Tree
Human Diseases
more
  • Diseases
    2 with Stk11 mouse models; 3 with human STK11 associations

Human Disease Mouse Models
       Peutz-Jeghers Syndrome; PJS   OMIM: 175200 View 9 models
       Endometrial Cancer   OMIM: 608089 View 1 model
       Pancreatic Cancer   OMIM: 260350
Testicular Germ Cell Tumor; TGCT   OMIM: 273300
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    6 with disease annotations
  • References
    13 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    138 phenotypes from 13 alleles in 24 genetic backgrounds
    27 phenotypes from multigenic genotypes
    2 images
    134 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    23
  • Chemically induced (other)
    1
  • Gene trapped
    3
  • Targeted
    19
  • Genomic Mutations
    2 involving Stk11
  • Incidental Mutations
Targeted heterozygous mutants with one inactivated allele develop benign gastrointestinal polyps. Homozygous null mutant are embryonic lethal. Homozygotes for a hypomorphic allele survive and apparently normal, but male mice are infertile.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000000002 VEGA Gene Model | MGI Sequence Detail 14880 C57BL/6J ±  kb
transcript OTTMUST00000045747 VEGA | MGI Sequence Detail 2566 Not Applicable  
polypeptide OTTMUSP00000020599 VEGA | MGI Sequence Detail 436 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    30 from dbSNP Build 142
  • PCR
Protein
Information
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  • UniProt
    5 Sequences
  • Protein Ontology
    PR:000015740 serine/threonine-protein kinase STK11
  • EC
  • InterPro Domains
    IPR020636 Calcium/calmodulin-dependent/calcium-dependent protein kinase
    IPR017441 Protein kinase, ATP binding site
    IPR000719 Protein kinase domain
    IPR011009 Protein kinase-like domain
    IPR008271 Serine/threonine-protein kinase, active site
Molecular
Reagents
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  • All nucleic 25
    Genomic 1
    cDNA 20
    Primer pair 4

    Microarray probesets 4
Other
Accession IDs
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MGI:2143460, MGI:2143959
References
more
  • Summaries
    All 186
    Developmental Gene Expression 11
    Diseases 13
    Gene Ontology 23
    Phenotypes 134
  • Earliest
    J:56026 Luukko K, et al., Expression of LKB1 and PTEN tumor suppressor genes during mouse embryonic development. Mech Dev. 1999 May;83(1-2):187-90
  • Latest
    J:230047 Griss T, et al., Metformin Antagonizes Cancer Cell Proliferation by Suppressing Mitochondrial-Dependent Biosynthesis. PLoS Biol. 2015 Dec;13(12):e1002309

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/12/2016
MGI 6.04
The Jackson Laboratory