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Stk11
Gene Detail
 Symbol
Name
ID
Stk11
serine/threonine kinase 11
MGI:1341870
Synonyms Lkb1, Par-4
Feature Type protein coding gene
Genetic Map
Chromosome 10
39.72 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr10:80115803-80130682 bp, + strand
From VEGA annotation of GRCm38

  14880 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:393  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Stk11

Human
homologs
Human Homolog STK11, serine/threonine kinase 11
NCBI Gene ID 6794
neXtProt AC  NX_Q15831
Human Synonyms  hLKB1, LKB1, PJS
Human Chr (Location)  19p13.3; chr19:1205799-1228435 (+)  GRCh38
Disease Associations  (3) Diseases Associated with Human STK11
Mutations,
alleles, and
phenotypes
All mutations/alleles(20) : Gene trapped(3) Targeted(17)
Incidental mutations (data from Mutagenetix , APF )
 
Targeted heterozygous mutants with one inactivated allele develop benign gastrointestinal polyps. Homozygous null mutant are embryonic lethal. Homozygotes for a hypomorphic allele survive and apparently normal, but male mice are infertile.
 
Human Diseases Modeled Using Mouse Stk11 (2)    Alleles Annotated to Human Diseases(6)    Phenotype Images(2)
Interactions
Stk11 interacts with 151 markers (Mir15a, Mir16-1, Mir16-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (79 annotations)
Process activation of protein kinase activity, anoikis, ...
Component cytoplasm, cytosol, ...
Function ATP binding, kinase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (10 records)
Data Summary: Results (62)    Tissues (39)    Images (15)
Theiler Stages: 10, 13, 14, 16, 18, 21, 22, 23, 25, 28
Assay TypeResults
Immunohistochemistry 6
RNA in situ 32
Northern blot 6
RT-PCR 18
cDNA source data(18)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(23) Genomic(1) cDNA(18) Primer pair(4)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000000002 (Evidence)
Ensembl Gene ModelENSMUSG00000003068 (Evidence)
Entrez Gene20869 (Evidence)
NIA Mouse Gene IndexU011738
EC2.7.11.1
Consensus CDS ProjectCCDS35974.1
International Mouse Knockout Project StatusStk11
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000000002 VEGA Gene Model | MGI Sequence Detail 14880 C57BL/6J ±  kb
transcript OTTMUST00000045747 VEGA | MGI Sequence Detail 2566 Not Applicable 
polypeptide OTTMUSP00000020599 VEGA | MGI Sequence Detail 436 Not Applicable 

For the selected sequences
All sequences(87) RefSeq(13) UniProt(6)
Polymorphisms PCR(1) : SNPs within 2kb(30 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR020636 Calcium/calmodulin-dependent/calcium-dependent protein kinase
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR002290 Serine/threonine- / dual specificity protein kinase, catalytic domain
InterPro IPR008271 Serine/threonine-protein kinase, active site
Protein Ontology PR:000015740 serine/threonine-protein kinase 11
References (Earliest) J:56026 Luukko K, et al., Expression of LKB1 and PTEN tumor suppressor genes during mouse embryonic development. Mech Dev. 1999 May;83(1-2):187-90
(Latest) J:210599 Xu C, et al., Loss of Lkb1 and Pten leads to lung squamous cell carcinoma with elevated PD-L1 expression. Cancer Cell. 2014 May 12;25(5):590-604
All references(151)
Disease annotation references (9)
Other
accession IDs
MGI:2143460, MGI:2143959

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory