Stk11
Gene Detail

Symbol Name ID

Stk11 serine/threonine kinase 11 MGI:1341870

Synonyms

Lkb1, Par-4

Feature Type

protein coding gene

Genetic Map

Chromosome 10

39.72 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr10:80115803-80130682 bp, + strand From VEGA annotation of GRCm38   14880 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:393  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Stk11

Human homologs

Human Homolog		STK11, serine/threonine kinase 11
NCBI Gene ID		6794
neXtProt AC		NX_Q15831
Human Synonyms		hLKB1, LKB1, PJS
Human Chr (Location)		19p13.3; chr19:1205798-1228434 (+)  GRCh37.p10
Disease Associations		(2) Diseases Associated with Human STK11

Alleles and phenotypes

All alleles(19) : Targeted(16) Gene trapped(3)
 

Targeted heterozygous mutants with one inactivated allele develop benign gastrointestinal polyps. Homozygous null mutant are embryonic lethal. Homozygotes for a hypomorphic allele survive and apparently normal, but male mice are infertile.

 
Human Diseases Modeled Using Mouse Stk11 (2)    Alleles Annotated to Human Diseases(6)    Phenotype Images(2)

Gene Ontology (GO) classifications

All GO classifications: (64 annotations)

Process	anoikis, apoptotic process, ...
Component	cytoplasm, cytosol, ...
Function	ATP binding, identical protein binding, ...

External Resources: FuncBase

Expression

Literature Summary: (8 records)
Data Summary: Results (59)    Tissues (36)    Images (15)
Theiler Stages: 10, 13, 14, 16, 18, 23, 25, 28

Assay Type	Results
Immunohistochemistry	3
RNA in situ	32
Northern blot	6
RT-PCR	18

cDNA source data(135)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(140) Genomic(1) cDNA(135) Primer pair(4)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000000002 (Evidence)
Ensembl Gene Model	ENSMUSG00000003068 (Evidence)
Entrez Gene	20869 (Evidence)
UniGene	44231
NIA Mouse Gene Index	U011738
EC	2.7.11.1
Consensus CDS Project	CCDS35974.1
International Mouse Knockout Project Status	Stk11

Sequences

Length	Strain/Species
genomic	OTTMUSG00000000002	VEGA Gene Model | MGI Sequence Detail	14880	C57BL/6J
transcript	OTTMUST00000045747	VEGA | MGI Sequence Detail	2566	Not Applicable
polypeptide	OTTMUSP00000020599	VEGA | MGI Sequence Detail	436	Not Applicable

All sequences(76) RefSeq(2) UniProt(6)

Polymorphisms

PCR(1) : SNPs(26 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR020636	Calcium/calmodulin-dependent/calcium-dependent protein kinase
InterPro	IPR017441	Protein kinase, ATP binding site
InterPro	IPR000719	Protein kinase, catalytic domain
InterPro	IPR011009	Protein kinase-like domain
InterPro	IPR002290	Serine/threonine- / dual specificity protein kinase, catalytic domain
InterPro	IPR008271	Serine/threonine-protein kinase, active site
Protein Ontology	PR:000015740	serine/threonine-protein kinase 11

References

(Earliest) J:56026 Luukko K, et al., Expression of LKB1 and PTEN tumor suppressor genes during mouse embryonic development. Mech Dev. 1999 May;83(1-2):187-90
(Latest) J:194330 Shackelford DB, et al., LKB1 inactivation dictates therapeutic response of non-small cell lung cancer to the metabolism drug phenformin. Cancer Cell. 2013 Feb 11;23(2):143-58
All references(128)

Other accession IDs

MGI:2143460, MGI:2143959