Automated description from the Alliance of Genome Resources (Release 7.0.0)
Enables LRR domain binding activity; protein kinase activator activity; and protein serine/threonine kinase activity. Involved in several processes, including cellular response to UV-B; negative regulation of cold-induced thermogenesis; and positive regulation of transforming growth factor beta receptor signaling pathway. Acts upstream of or within several processes, including dendrite extension; regulation of neuron projection development; and regulation of signal transduction. Located in cytosol; membrane; and nucleus. Is expressed in several structures, including alimentary system; blood; genitourinary system; lung; and nervous system. Used to study Peutz-Jeghers syndrome; endometrial cancer; lung cancer; and urinary bladder cancer. Human ortholog(s) of this gene implicated in Peutz-Jeghers syndrome; cervical mucinous adenocarcinoma; familial melanoma; ovarian carcinoma; and pancreatic cancer. Orthologous to human STK11 (serine/threonine kinase 11).