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Men1
Gene Detail
 Symbol
Name
ID
Men1
multiple endocrine neoplasia 1
MGI:1316736
Synonyms menin
Feature Type protein coding gene
Genetic Map
Chromosome 19
4.45 cM, cytoband A
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr19:6334979-6340891 bp, + strand
From VEGA annotation of GRCm38

  5913 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7418  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

Gene Tree: Men1

Human
homologs
Human Homolog MEN1, multiple endocrine neoplasia I
NCBI Gene ID 4221
neXtProt AC  NX_O00255
Human Synonyms  MEAI, SCG2
Human Chr (Location)  11q13; chr11:64803514-64811294 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human MEN1
Mutations,
alleles, and
phenotypes
All mutations/alleles(21) : Gene trapped(6) Targeted(15)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for targeted null mutations die at embryonic day 11.5-13.5 with reduced size, edema, open neural tube and defects of the nervous system, heart and liver. Heterozygotes develop tumors of the pancreas, parathyroid, thyroid, adrenal and pituitary.
 
Human Diseases Modeled Using Mouse Men1 (5)    Alleles Annotated to Human Diseases(6)   
Interactions
Men1 interacts with 139 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (90 annotations)
Process cell cycle arrest, cellular response to DNA damage stimulus, ...
Component chromatin, cleavage furrow, ...
Function chromatin binding, DNA binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (13 records)
Data Summary: Results (19)    Tissues (14)    Images (2)
Theiler Stages: 17, 19, 20
Assay TypeResults
RNA in situ 14
Western blot 3
RT-PCR 2
cDNA source data(23)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(32) Genomic(7) cDNA(23) Primer pair(2)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000018611 (Evidence)
Ensembl Gene ModelENSMUSG00000024947 (Evidence)
Entrez Gene17283 (Evidence)
DFCITC1574234, TC1749051, TC1767446
DoTSDT.101398430, DT.101398431, DT.101398435, DT.110731800, DT.110863100, DT.40187076, DT.94334799, DT.94334806
NIA Mouse Gene IndexU038691
Consensus CDS ProjectCCDS29502.1, CCDS50366.1, CCDS50367.1
International Mouse Knockout Project StatusMen1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000018611 VEGA Gene Model | MGI Sequence Detail 5913 C57BL/6J ±  kb
transcript OTTMUST00000083389 VEGA | MGI Sequence Detail 1851 Not Applicable 
polypeptide OTTMUSP00000044804 VEGA | MGI Sequence Detail 616 Not Applicable 

For the selected sequences
All sequences(113) RefSeq(8) UniProt(6)
Polymorphisms PCR(1) : SNPs within 2kb(3 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR007747 Menin
Protein Ontology PR:000010321 menin
References (Earliest) J:51201 Stewart C, et al., Characterization of the mouse Men1 gene and its expression during development. Oncogene. 1998 Nov 12;17(19):2485-93
(Latest) J:202501 Li BE, et al., Distinct pathways regulated by menin and by MLL1 in hematopoietic stem cells and developing B cells. Blood. 2013 Sep 19;122(12):2039-46
All references(106)
Disease annotation references (6)
Other
accession IDs
MGI:2147685

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/16/2014
MGI 5.19
The Jackson Laboratory