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Men1 Gene Detail
Summary
  • Symbol
    Men1
  • Name
    multiple endocrine neoplasia 1
  • Synonyms
    menin
  • Feature Type
    protein coding gene
  • IDs
    MGI:1316736
    NCBI Gene: 17283
  • Gene Overview
    MyGene.info: MEN1
Location & Maps
more
  • Genetic Map
    Chromosome 19, 4.45 cM, cytoband A
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    MEN1, menin 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    MEN1, menin 1
    Orthology source: HomoloGene
  • Synonyms
    MEAI, SCG2
  • Links
    NCBI Gene ID: 4221
    neXtProt AC: NX_O00255

  • Chr Location
    11q13; chr11:64803514-64811294 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 7418
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: MEN1
  • Gene Tree
Human Diseases
more
  • Diseases
    3 with Men1 mouse models; 1 with human MEN1 associations

Human Disease Mouse Models
       Multiple Endocrine Neoplasia, Type I; MEN1   OMIM: 131100 View 6 models
       Hyperparathyroidism 1; HRPT1   OMIM: 145000 View 1 model
Pituitary Adenoma, Prolactin-Secreting   OMIM: 600634 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    6 with disease annotations
  • References
    6 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    78 phenotypes from 12 alleles in 14 genetic backgrounds
    24 phenotypes from multigenic genotypes
    64 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    21
  • Gene trapped
    6
  • Targeted
    15
  • Incidental Mutations
Homozygotes for targeted null mutations die at embryonic day 11.5-13.5 with reduced size, edema, open neural tube and defects of the nervous system, heart and liver. Heterozygotes develop tumors of the pancreas, parathyroid, thyroid, adrenal and pituitary.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000018611 VEGA Gene Model | MGI Sequence Detail 5913 C57BL/6J ±  kb
transcript OTTMUST00000083389 VEGA | MGI Sequence Detail 1851 Not Applicable  
polypeptide OTTMUSP00000044804 VEGA | MGI Sequence Detail 616 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    3 from dbSNP Build 142
  • PCR
Protein
Information
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Molecular
Reagents
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  • All nucleic 32
    Genomic 7
    cDNA 23
    Primer pair 2

    Microarray probesets 5
Other
Accession IDs
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MGI:2147685
References
more
  • Summaries
    All 118
    Developmental Gene Expression 14
    Diseases 6
    Gene Ontology 30
    Phenotypes 64
  • Earliest
    J:51201 Stewart C, et al., Characterization of the mouse Men1 gene and its expression during development. Oncogene. 1998 Nov 12;17(19):2485-93
  • Latest
    J:231004 Smith TL, et al., AAVP displaying octreotide for ligand-directed therapeutic transgene delivery in neuroendocrine tumors of the pancreas. Proc Natl Acad Sci U S A. 2016 Mar 1;113(9):2466-71

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory