Men1
Gene Detail

Symbol Name ID

Men1 multiple endocrine neoplasia 1 MGI:1316736

Synonyms

menin

Feature Type

protein coding gene

Genetic Map

Chromosome 19

4.45 cM, cytoband A
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr19:6334979-6340891 bp, + strand From VEGA annotation of GRCm38   5913 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:7418  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 2 zebrafish

Gene Tree: Men1

Human homologs

Human Homolog		MEN1, multiple endocrine neoplasia I
NCBI Gene ID		4221
neXtProt AC		NX_O00255
Human Synonyms		MEAI, SCG2
Human Chr (Location)		11q13; chr11:64570986-64578766 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human MEN1

Alleles and phenotypes

All alleles(21) : Targeted(15) Gene trapped(6)
 

Homozygotes for targeted null mutations die at embryonic day 11.5-13.5 with reduced size, edema, open neural tube and defects of the nervous system, heart and liver. Heterozygotes develop tumors of the pancreas, parathyroid, thyroid, adrenal and pituitary.

 
Human Diseases Modeled Using Mouse Men1 (5)    Alleles Annotated to Human Diseases(6)   

Gene Ontology (GO) classifications

All GO classifications: (89 annotations)

Process	cell cycle arrest, chromatin modification, ...
Component	chromatin, cleavage furrow, ...
Function	chromatin binding, DNA binding, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (13 records)
Data Summary: Results (19)    Tissues (14)    Images (2)
Theiler Stages: 17, 19, 20

Assay Type	Results
RNA in situ	14
Western blot	3
RT-PCR	2

cDNA source data(23)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(32) Genomic(7) cDNA(23) Primer pair(2)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000018611 (Evidence)
Ensembl Gene Model	ENSMUSG00000024947 (Evidence)
Entrez Gene	17283 (Evidence)
DFCI	TC1574234, TC1749051, TC1767446
DoTS	DT.101398430, DT.101398431, DT.101398435, DT.110731800, DT.110863100, DT.40187076, DT.94334799, DT.94334806
NIA Mouse Gene Index	U038691
Consensus CDS Project	CCDS29502.1, CCDS50366.1, CCDS50367.1
International Mouse Knockout Project Status	Men1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000018611	VEGA Gene Model | MGI Sequence Detail	5913	C57BL/6J
transcript	OTTMUST00000083389	VEGA | MGI Sequence Detail	1851	Not Applicable
polypeptide	OTTMUSP00000044804	VEGA | MGI Sequence Detail	616	Not Applicable

All sequences(113) RefSeq(8) UniProt(6)

Polymorphisms

PCR(1) : SNPs(2 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR007747	Menin
Protein Ontology	PR:000010321	menin

References

(Earliest) J:51201 Stewart C, et al., Characterization of the mouse Men1 gene and its expression during development. Oncogene. 1998 Nov 12;17(19):2485-93
(Latest) J:192496 Xu S, et al., Tumor suppressor menin mediates peripheral nerve injury-induced neuropathic pain through potentiating synaptic plasticity. Neuroscience. 2012 Oct 25;223:473-85
All references(101)

Other accession IDs

MGI:2147685