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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Men1
multiple endocrine neoplasia 1
MGI:1316736
26 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
\Cdkn1btm1Ako/\Cdkn1btm1Ako
\Men1tm1.1Ctre/\Men1+
involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6 		increased adrenal gland tumor incidence J:120835
increased lung adenoma incidence J:120835
increased pancreas tumor incidence J:120835
increased parathyroid gland tumor incidence J:120835
increased pituitary gland tumor incidence J:120835
increased testis tumor incidence J:120835
increased thyroid tumor incidence J:120835
increased tumor incidence J:120835
\Cdkn1btm1Ako/\Cdkn1btm1Ako
\Men1tm1.1Ctre/\Men1tm1.1Ctre
involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6 		embryonic lethality, complete penetrance J:120835
\Cdkn2ctm1Yxi/\Cdkn2ctm1Yxi
\Men1tm1.1Ctre/\Men1+
involves: 129/Sv * 129S6/SvEvTac * C57BL/6 		decreased tumor latency J:120835
increased adenocarcinoma incidence J:120835
increased adrenal gland tumor incidence J:120835
increased Leydig cell tumor incidence J:120835
increased lung adenocarcinoma incidence J:120835
increased lung adenoma incidence J:120835
increased lung tumor incidence J:120835
increased pancreas tumor incidence J:120835
increased parathyroid gland tumor incidence J:120835
increased testis tumor incidence J:120835
increased thyroid tumor incidence J:120835
\Cdkn2ctm1Yxi/\Cdkn2ctm1Yxi
\Men1tm1.1Ctre/\Men1tm1.1Ctre
involves: 129/Sv * 129S6/SvEvTac * C57BL/6 		embryonic lethality, complete penetrance J:120835
\Kdm5atm1Kael/\Kdm5atm1Kael
\Men1tm2.1Mmey/\Men1tm2.1Mmey
\Tg(Ins2-cre)23Herr/0
involves: 129S6/SvEvTac * C57BL/6 * CBA/J * FVB/N 		abnormal pancreatic islet morphology J:175625
normal endocrine/exocrine gland phenotype J:175625
increased insulinoma incidence J:175625
pancreatic islet hyperplasia J:175625
premature death J:175625
\Men1tm1.1Ctre/\Men1+
\Rb1tm1Tyj/\Rb1+
involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6J * FVB/N 		increased adrenal gland tumor incidence J:133299
increased metastatic potential J:133299
increased pancreas tumor incidence J:133299
increased parathyroid gland tumor incidence J:133299
increased pheochromocytoma incidence J:133299
increased pituitary adenohypophysis tumor incidence J:133299
increased pituitary melanotroph tumor incidence J:133299
increased thyroid C-cell carcinoma incidence J:133299
premature death J:133299
\Men1tm1.2Ctre/\Men1tm1.2Ctre
\Pax3tm1(cre)Joe/\Pax3+
\Gt(ROSA)26Sortm1Sor/\Gt(ROSA)26Sor+
involves: 129S4/SvJaeSor * 129S6/SvEvTac 		normal cardiovascular system phenotype J:127545
normal digestive/alimentary phenotype J:127545
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory