Cldn1
Gene Detail

Symbol Name ID

Cldn1 claudin 1 MGI:1276109

Feature Type

protein coding gene

Genetic Map

Chromosome 16

18.00 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr16:26356642-26371841 bp, - strand From VEGA annotation of GRCm38   15200 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:9620  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Cldn1

Human homologs

Human Homolog		CLDN1, claudin 1
NCBI Gene ID		9076
neXtProt AC		NX_O95832
Human Synonyms		CLD1, ILVASC, SEMP1
Human Chr (Location)		3q28-q29; chr3:190023490-190040235 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human CLDN1

Alleles and phenotypes

All alleles(4) : Targeted(4)
 

Animals homozygous for a mutation in this gene have wrinkled skin and die within 1 day after birth.

 
Phenotype Images(4)

Gene Ontology (GO) classifications

All GO classifications: (16 annotations)

Process	calcium-independent cell-cell adhesion, cell-cell junction organization
Component	apical plasma membrane, cell junction, ...
Function	identical protein binding, protein binding, ...

External Resources: FuncBase

Expression

Literature Summary: (27 records)
Data Summary: Results (174)    Tissues (60)    Images (39)
Theiler Stages: 19, 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
Immunohistochemistry	12
RNA in situ	154
Western blot	2
RT-PCR	6

cDNA source data(72)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(75) cDNA(72) Primer pair(3)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000022624 (Evidence)
Ensembl Gene Model	ENSMUSG00000022512 (Evidence)
Entrez Gene	12737 (Evidence)
UniGene	289441
DFCI	TC1575234
DoTS	DT.101739680, DT.55100124, DT.97363823
NIA Mouse Gene Index	U036934
Consensus CDS Project	CCDS28087.1
International Mouse Knockout Project Status	Cldn1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000022624	VEGA Gene Model | MGI Sequence Detail	15200	C57BL/6J
transcript	OTTMUST00000054195	VEGA | MGI Sequence Detail	3247	Not Applicable
polypeptide	OTTMUSP00000025830	VEGA | MGI Sequence Detail	211	Not Applicable

All sequences(33) RefSeq(2) UniProt(3)

Polymorphisms

SNPs(55 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR006187	Claudin
InterPro	IPR003548	Claudin-1
InterPro	IPR017974	Claudin, conserved site
InterPro	IPR004031	PMP-22/EMP/MP20/Claudin
Protein Ontology	PR:000005537	claudin-1

References

(Earliest) J:48635 Furuse M, et al., Claudin-1 and -2: novel integral membrane proteins localizing at tight junctions with no sequence similarity to occludin. J Cell Biol. 1998 Jun 29;141(7):1539-50
(Latest) J:194053 Liu B, et al., Cbx4 regulates the proliferation of thymic epithelial cells and thymus function. Development. 2013 Feb;140(4):780-8
All references(78)

Other accession IDs

MGI:2146462