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Cldn1
Gene Detail
Symbol

Name
ID
Cldn1
claudin 1
MGI:1276109
Feature Type
protein coding gene
Genetic Map
Chromosome 16
18.00 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr16:26356642-26371841 bp, - strand
From VEGA annotation of GRCm38

  15200 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:9620  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: CLDN1
Gene Tree: Cldn1

Human
homologs
CLDN1, claudin 1
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 9076
neXtProt AC: NX_O95832

Human Synonyms: CLD1, ILVASC, SEMP1

Human Chr (Location): 3q28-q29; chr3:190305701-190322446 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human CLDN1

Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from APF )
 
Animals homozygous for a mutation in this gene have wrinkled skin and die within 1 day after birth.
 
Phenotype Images(4)
Interactions
Cldn1 interacts with 311 markers (Mir7-1, Mir9-1, Mir9-2, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (35 records)
Data Summary: Results (207)    Tissues (90)    Images (45)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 12
RNA in situ 187
Western blot 2
RT-PCR 6
cDNA source data(73)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: GEISHA CLDN1 ; Xenbase cldn1 ; ZFIN cldn1    NEW 
Molecular
reagents
All nucleic(76) cDNA(73) Primer pair(3)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000022624 (Evidence)
Ensembl Gene Model ENSMUSG00000022512 (Evidence)
Entrez Gene 12737 (Evidence)
UniGene 289441
DFCI TC1575234
DoTS DT.101739680, DT.55100124, DT.97363823
NIA Mouse Gene Index U036934
Consensus CDS Project CCDS28087.1
International Mouse Phenotyping Consortium Status Cldn1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022624 VEGA Gene Model | MGI Sequence Detail 15200 C57BL/6J ±  kb
transcript OTTMUST00000054195 VEGA | MGI Sequence Detail 3247 Not Applicable 
polypeptide OTTMUSP00000025830 VEGA | MGI Sequence Detail 211 Not Applicable 

For the selected sequences
All sequences(33) RefSeq(2) UniProt(3)
Polymorphisms
SNPs within 2kb(94 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006187 Claudin
InterPro IPR003548 Claudin-1
InterPro IPR017974 Claudin, conserved site
InterPro IPR004031 PMP-22/EMP/MP20/Claudin superfamily
Protein Ontology PR:000005537 claudin-1
References
(Earliest) J:48635 Furuse M, et al., Claudin-1 and -2: novel integral membrane proteins localizing at tight junctions with no sequence similarity to occludin. J Cell Biol. 1998 Jun 29;141(7):1539-50
(Latest) J:221394 Szabo R, et al., Regulation of feto-maternal barrier by matriptase- and PAR-2-mediated signaling is required for placental morphogenesis and mouse embryonic survival. PLoS Genet. 2014 Jul;10(7):e1004470
All references(87)
Other
accession IDs
MGI:2146462

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory