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Cldn1
Gene Detail
 Symbol
Name
ID
Cldn1
claudin 1
MGI:1276109
Feature Type protein coding gene
Genetic Map
Chromosome 16
18.00 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr16:26356642-26371841 bp, - strand
From VEGA annotation of GRCm38

  15200 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:9620  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Cldn1

Human
homologs
Human Homolog CLDN1, claudin 1
NCBI Gene ID 9076
neXtProt AC  NX_O95832
Human Synonyms  CLD1, ILVASC, SEMP1
Human Chr (Location)  3q28-q29; chr3:190305701-190322446 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human CLDN1
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from APF )
 
Animals homozygous for a mutation in this gene have wrinkled skin and die within 1 day after birth.
 
Phenotype Images(4)
Interactions
Cldn1 interacts with 311 markers (Mir7-1, Mir9-1, Mir9-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (21 annotations)
Process calcium-independent cell-cell adhesion, cell-cell junction organization, ...
Component apical plasma membrane, cell junction, ...
Function identical protein binding, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (32 records)
Data Summary: Results (202)    Tissues (85)    Images (41)
Theiler Stages: 19, 20, 21, 22, 23, 24, 25, 26, 27, 28
Assay TypeResults
Immunohistochemistry 12
RNA in situ 182
Western blot 2
RT-PCR 6
cDNA source data(72)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(75) cDNA(72) Primer pair(3)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000022624 (Evidence)
Ensembl Gene ModelENSMUSG00000022512 (Evidence)
Entrez Gene12737 (Evidence)
UniGene289441
DFCITC1575234
DoTSDT.101739680, DT.55100124, DT.97363823
NIA Mouse Gene IndexU036934
Consensus CDS ProjectCCDS28087.1
International Mouse Knockout Project StatusCldn1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022624 VEGA Gene Model | MGI Sequence Detail 15200 C57BL/6J ±  kb
transcript OTTMUST00000054195 VEGA | MGI Sequence Detail 3247 Not Applicable 
polypeptide OTTMUSP00000025830 VEGA | MGI Sequence Detail 211 Not Applicable 

For the selected sequences
All sequences(33) RefSeq(2) UniProt(3)
Polymorphisms SNPs within 2kb(94 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006187 Claudin
InterPro IPR003548 Claudin-1
InterPro IPR017974 Claudin, conserved site
InterPro IPR004031 PMP-22/EMP/MP20/Claudin
Protein Ontology PR:000005537 claudin-1
References (Earliest) J:48635 Furuse M, et al., Claudin-1 and -2: novel integral membrane proteins localizing at tight junctions with no sequence similarity to occludin. J Cell Biol. 1998 Jun 29;141(7):1539-50
(Latest) J:199582 Youssef G, et al., Rab3Gap1 mediates exocytosis of Claudin-1 and tight junction formation during epidermal barrier acquisition. Dev Biol. 2013 Aug 15;380(2):274-85
All references(86)
Other
accession IDs
MGI:2146462

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/16/2014
MGI 5.19
The Jackson Laboratory